Effect of paclitaxel / carboplatin salvage chemotherapy in noncutaneous versus cutaneous metastatic melanoma.
Fostamatinib's effect on microtubules seems to increase the stabilizing
effect of paclitaxel, even in resistant cells, which in turn may prevent cancer cells from proliferating, says Yu Yu, Ph.D., a postdoctoral fellow at the Johns Hopkins University School of Medicine and co-author of the study.
The effects of paclitaxel, a chemotherapy drug, can be seen on the cellular structures of the skin of a larval zebrafish tail fin.
Not exact matches
Based on what is already known about fostamatinib toxicity, Shih says that patients using a combination
of fostamatinib and
paclitaxel may experience side
effects that include low white blood cell counts, nausea, vomiting and diarrhea.
«The significance
of this trial is that many patients... develop an allergy to what is mixed with
paclitaxel, creating more side
effects,» said Dr. Williamson.
Oral administration
of mebendazole in mice elicited a strong antitumor
effect in a subcutaneous model and reduced lesions in experimentally induced lung metastasis without any toxicity when compared with
paclitaxel - treated mice [9,20].
Paclitaxel (Taxol ®) is a widely - used anticancer agent for treatment
of ovarian, breast, lung, head, and neck cancer with two serious side
effects: myelosuppression and peripheral sensory neurotoxicity which limits its use in high / cumulative doses or in combination with other anticancer agents.
The albumin - formulation eliminated the need for an organic solvent — required for delivery
of free
paclitaxel — thus eliminating solvent - related side
effects.