Sentences with phrase «effect of the loss of»

«We're already seeing very detrimental effects of this loss of connectivity,» she says.

To determine the effects of the loss of IL - 15Rα on exercise performance in vivo, we quantified activity of IL - 15Rα — KO mice and B6129 control mice using two different assays: cage wheel running and quantification of photobeam breaks.

These data demonstrate a preferential effect of loss of IL - 15Rα on normalized skeletal muscle mass that is not seen in non-skeletal muscle tissue (i.e., heart, spleen, kidney).

Without extensive tests of cognitive function prior to the onset of sleep apnea, «we can't measure the effect of the loss of neurons,» Gozal said.

The effects of loss of bsl1 function were highly dependent on spatiotemporal context.

The Czech Centre for Phenogenomics (CCP), through its membership in INFRAFRONTIER and IMPC, is a partner in a collective global network that aims to comprehensively and systematically analyze the effect of loss of function gene mutations in mice.

We examined the effect of loss of the gene on bacterial motility, adhesion and invasion of tissue culture cells and chicken colonisation, as well as the effect on the muropeptide profile of the peptidoglycan sacculus.

Ice also reduced metabolic activity in the tissues that are iced, making them better able to resist the damaging effects of loss of oxygen from inflammatory swelling pressure (2).

During aging the ceramide level in our skin decreases, which leads to wrinkles and loss of firmness, but applying ceramides topically can help to reduce the effect of the loss of the ceramides.

While the number of school fires has decreased over recent years, the costs associated with school fires have escalated, while the effects of loss of facilities, equipment, coursework, disruption of classes and lowering of morale also have a significant impact.

There may be a need to evaluate possible methods for counteracting the effects of loss of sex hormones in gonadectomized dogs.

The emotional shock of losing a body part could take many years and usually, an amputee or disfigurement victim will need special pain medication, psychotherapy and hospitalization to deal with the serious after effects of loss of a limb.

It is an inexpensive tool to protect a corporation or other business entity from the damaging effects of the loss of a key employee or business owner.

A means of protecting a business from the adverse effects of the loss of individuals possessing special managerial or technical skill or experience.

(161) A key consideration of the «Strengthening Youth Wellbeing» strategy is the link between youth suicide and the effects of loss of Maori identity and culture.

Households could also take out smaller home loans to reduce the effects of the loss of the mortgage interest deduction, and the larger standard deduction may give them more purchasing power.

Found on page 5 of the Closing Disclosure (Liability after Foreclosure), the consumer must be informed before the time of consummation if state law protections are afforded under any anti-deficiency law and the effect of any loss of this protection.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

In the opinion of the Company's management, adjusted book value per share is useful in an analysis of a property casualty company's book value per share as it removes the effect of changing prices on invested assets (i.e., net unrealized investment gains (losses), net of tax), which do not have an equivalent impact on unpaid claims and claim adjustment expense reserves.

Adjusted shareholders» equity is shareholders» equity excluding net unrealized investment gains (losses), net of tax, included in shareholders» equity, net realized investment gains (losses), net of tax, for the period presented, the effect of a change in tax laws and tax rates at enactment (excluding the portion related to net unrealized investment gains (losses)-RRB-, preferred stock and discontinued operations.

Core income (loss) is consolidated net income (loss) excluding the after - tax impact of net realized investment gains (losses), discontinued operations, the effect of a change in tax laws and tax rates at enactment, and cumulative effect of changes in accounting principles when applicable.

One group looked at the effect of sleep loss on productivity at four American companies and found employees who weren't sleeping well or enough to be roughly twice as likely to report difficulties with time management, decision - making and motivation.

Some say the benefit of tax - loss harvesting is overstated, that the net effect of selling securities that are down and buying them back really just amounts to a tax deferral for most.

Others maintain that the cumulative effect of harvesting losses year after year can inadvertently subject investors to a higher capital gains rate later on, which negates any savings and then some.

While the loss of the city has no immediate effect on oil exports, now at over three million barrels a day, it adds to concerns over security and the country's plans to expand oil production.

Even chronic partial - sleep loss of four to seven hours a night over several nights (not just total sleep deprivation) is associated with these side effects.

«Furthermore, although the average sentence lengths (conditional on case, defendant and judge attributes) do not differ by defendant race in the absence of a football effect, it appears that an upset LSU football game loss increases the disposition length (sentence severity) of black defendants more severely in comparison to white defendants.

He went on to win the case, and Gawker declared bankruptcy as a direct effect of the monetary loss from the case.

Despite the fact that human studies haven't yet been done to observe the effect of raspberry ketones on weight loss in humans, products with the supposed weight - loss ingredient are flying off the shelves.

I worry about these and we have studied them extensively, but I also worry there are even more powerful effects we must mitigate around sensationalism and polarization leading to a loss of common understanding.

«If there are any negative effects of low rates on net interest income in the future, they should be largely offset by the positive effects of monetary stimulus on the other main components of profitability, such as the quality of loans and therefore on loan - loss provisions,» Draghi added.

The response to this «γ effect» is big enough for Canada to convert a net production loss of 163,000 into a production gain of 229,000.

Loss on impairment of long - term investments - We exclude the effect of any other - than - temporary impairment of a cost method investment in calculating our non-GAAP financial measures.

These risks include, in no particular order, the following: the trends toward more high - definition, on - demand and anytime, anywhere video will not continue to develop at its current pace or will expire; the possibility that our products will not generate sales that are commensurate with our expectations or that our cost of revenue or operating expenses may exceed our expectations; the mix of products and services sold in various geographies and the effect it has on gross margins; delays or decreases in capital spending in the cable, satellite, telco, broadcast and media industries; customer concentration and consolidation; the impact of general economic conditions on our sales and operations; our ability to develop new and enhanced products in a timely manner and market acceptance of our new or existing products; losses of one or more key customers; risks associated with our international operations; exchange rate fluctuations of the currencies in which we conduct business; risks associated with our CableOS ™ and VOS ™ product solutions; dependence on market acceptance of various types of broadband services, on the adoption of new broadband technologies and on broadband industry trends; inventory management; the lack of timely availability of parts or raw materials necessary to produce our products; the impact of increases in the prices of raw materials and oil; the effect of competition, on both revenue and gross margins; difficulties associated with rapid technological changes in our markets; risks associated with unpredictable sales cycles; our dependence on contract manufacturers and sole or limited source suppliers; and the effect on our business of natural disasters.

24/7 Wall St. can tally up losses of more than $ 25 billion that would be in effect if Buffett were forced into an instant mark - to - market or similar exercise.

At the same time, the Department notes that the NPRM RIA's illustration of potential investor losses was incomplete because it represented only one negative effect of one source of conflict in one market segment.

U.S. stocks have already retraced a large part of their early February losses, but we believe the coming positive effects of new U.S. tax and spending plans are still underappreciated by markets.

Another reason analysts consider the January effect less important as of 2016 is that more people are using tax - sheltered retirement plans and therefore have no reason to sell at the end of the year for a tax loss.

Studies in behavioral finance, which look into the effects of investor psychology on stock prices, also reveal investors are subject to many biases such as confirmation, loss aversion and overconfidence biases.

Most financial analysts expect that an insured loss of even $ 10 billion would have little effect on the insurance and reinsurance industries, aside from a probable hit to fourth - quarter earnings.

In viewing your chart in one of your other posts regarding the long term returns of long bonds when current yield is under 3 %, why would I want to diversify into almost certain loss, after effects of inflation?

High loonie due to petrodollar effect = > loss of profit margin due to decline in final US selling price wrt Canadian dollar costs = > layoffs = > Dutch Disease.

«Negative publicity or public opinion resulting from these matters may increase the risk of reputational harm to our business, which can impact our ability to keep and attract customers, our ability to attract and retain qualified team members, result in the loss of revenue, or have other material adverse effects on our results of operations and financial condition.»

The loss of the CGS market could have an adverse effect on the standing of Australian markets.

But we don't count those foreign jobs when we calculate productivity (and the deduction to GDP on account of imports is generally smaller than the corresponding loss of U.S. employment), so foreign outsourcing has the effect of boosting measured productivity.

For the calculation of diluted net loss per share, net loss per share attributable to common stockholders and preferred Series D, E, F, and FP preferred stockholders for basic net loss per share is adjusted by the effect of dilutive securities, including awards under our equity compensation plans.

Meanwhile, extreme valuations imply the likelihood of steep market losses over the complete cycle, and also for poor S&P 500 total returns on a 10 - 12 year horizon, but valuations often have little effect on near - term market behavior.

In the years ended December 31, 2015 and 2016 our potential dilutive shares, such as stock options, RSUs, common stock subject to repurchase, and shares of convertible Series A, A-1, B, and C preferred stock were not included in the computation of diluted net loss per share as the effect of including these shares in the calculation would have been anti-dilutive.

The improvement for the nine months ended July 31, 2011 was driven primarily by lower litigation costs and lower currency transaction losses, the effect of which was partially offset by certain asset impairment charges.

Despite risks that I fully expect to devolve into a roughly -65 % loss in the S&P 500 over the completion of the current market cycle, it's absolutely critical to distinguish the long - term effects of valuation from the shorter - term effects speculative pressure.