Sentences with phrase «effect of the treatment increased»

Together with partial response (useful benefit but still some significant complaints), the positive effect of the treatment increased to 65 - 68 per cent and 70 - 88 per cent respectively.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The combined pressures of climate change and epidemics sweeping through intensive animal agriculture such as H5N2 avian flu and porcine epidemic diarrhea virus (PEDV) are growing challenges for industrial agriculture, and workers organizing to demand fair pay and conditions combined with increasing consumer pressure for greater transparency and better treatment of land, animals, and workers, are having an effect.

Clomiphene Citrate: A prescription drug typically usedfor the treatment of female infertility, it is taken by male athletes to negatethe effects of increased estrogen, a result of anabolic steroid abuse.

A large number of ovaries increases the chance of pregnancy, but unfortunately has also been associated with ovarian hyperstimulation syndrome (OHSS), which is sometimes called the most important side effect of fertility treatment.

Second, because the exercise treatment did not increase the TEE, the effect of adding exercise to normal activity could not be evaluated.

This is likely to have diluted overall treatment effects but these estimates may be more appropriate given the possibility of response bias and the increased likelihood of women who stopped breastfeeding dropping out before those who continued.

The long - term side effects of HIV drug treatment, such as increased cholesterol and heart disease, that crop up after 10 or 15 years will still occur.

Among patients with prostate cancer, those who smoke have increased risks of experiencing side effects from treatment and of developing future cancer recurrences, or even dying from prostate cancer.

U.S. Health & Human Services Secretary Sylvia Burwell last year proposed a response, calling for a program to change doctors» opioid prescribing practices, to expand the use of naloxone, a drug used to reverse the effects of an opioid overdoses, and increase patient access to medication assisted treatments for opioid use disorders.

If borne out by future studies, these mechanisms suggest some possible treatments to mitigate the effects of altitude on depression and suicide risk: supplemental 5 - hydroxytryptophan (a serotonin precursor) to increase serotonin levels, or creatinine to influence brain bioenergetics.

Since children of mothers with preclinical RA also had an increased risk of epilepsy, Rom said the findings point towards an important role of the disease itself rather than an effect of treatments for RA.

The risk of severe side effects was similar in both groups (67.2 % in the combination group and 65.8 % in the standard treatment group), although there was an increased risk of acute kidney injury with the combination treatment (5.2 % vs. 0.5 %).

Whilst they are highly effective, they also have numerous disadvantages: in some cases treatment had to be abandoned due to acute side effects, including marked increases of liver enzymes, with the result that CGRP receptor antagonists have not been approved to date.

With a sample size of 30 participants, the researchers tested the effects of removing MSG, increasing water intake, or a combination of both, relative to acetaminophen (the main treatment option available in Meru).

However, all other outcomes failed to show an effect of baclofen: baclofen did not increase abstinent days or decrease number of heavy drinking days during treatment, neither did it reduce rates of alcohol craving, anxiety or depression.

It is possible that medical advances over the past few decades in the treatment of type 2 diabetes, hypertension and high cholesterol levels have had a greater impact on people who are overweight — which increases the risk for these conditions — whereas the effect was much smaller in those of normal weight.

The PACE trial, published in The Lancet in 2011 [2], examined the effects of three different treatments for people with CFS, compared with usual specialist medical care (SMC): cognitive behaviour therapy (CBT, where a health professional helps the patient to understand and change the way they think about and respond to their symptoms), graded exercise therapy (GET, a personalised and gradually increasing exercise programme delivered by a physiotherapist), and adaptive pacing therapy (APT, where patients adapt activity levels to the amount of energy they have).

By suppressing the immune system in its entirety, however, this mode of treatment carries with it an increased risk of infections and other harmful side effects.

Even more selective treatments, with fewer side effects, cause physiological reactions that increase the aggressiveness of the disease.»

«However, while these encouraging results in mice mean that the zinc finger looks like a good candidate to take forward to human trials, we still need to do a lot of work first to answer important questions around the safety of the intervention, whether repeat treatments are effective, whether there might be longer - term side effects, and whether we can extend and increase the benefits beyond six months.

«Cancer doesn't sleep: MYC oncogene disrupts clock, metabolism in cancer cells: Findings inform time - dependent treatment for reducing side effects, increasing effectiveness of cancer medications.»

Possible long - term interventions to reduce mortality and morbidity after high exposures end include disease screening, reducing important co-exposures, treatment and health services resource planning, and increasing public awareness of arsenic health effects.

Steroids have been effective at suppressing inflammation, but if used for long - term treatment they can cause serious side effects such as increased risk of infections, liver damage, fluid retention, increased blood pressure, weight gain, easy bruising and slower wound healing.

When the potential modifying effect of using hormone treatment at the time of premature menopause was examined, there was some evidence that it may be beneficial for visual memory, but it could increase the risk of poor verbal fluency.

However, treatments of psychiatric disorders (e.g., drugs and cognitive behavior therapy) could not increase or decrease a specific connectivity between two regions, because these methods give broad effects on the global network.

The effect of glucocorticoid treatment is most prominent on trabecular bone and is therefore likely to be larger on vertebral bone than on hip bone.3 Glucocorticoids are associated with an increased rate of fracture, and higher doses and longer use of glucocorticoids are associated with higher risks of fracture.4 Compared with patients not taking glucocorticoids, the risk of hip and vertebral fracture among patients taking glucocorticoids is increased by 60 % and 160 %, respectively.4 Among 80 - year - old patients, the hip fracture risk is increased by a magnitude of 2.1 and is independent of BMD.5 Most studies indicate that fracture risk is increased following at least 3 months of treatment with daily doses of 5 mg of prednisolone or more in older men and women.4

The failure in pancreatic cancer treatment is main due to the presence of a dense and poorly vascularized stroma that increase the drug clearance in the tumors rather than the healthy tissues, decreasing drug bioavailability in the target tissue and leading to significant side effects.

«We predict that following the treatment, neuroimaging will show increased activation in regions of the brain critical for facial affect recognition, correlating with the effects of the intervention.

A personalized treatment would increase the chances of success, while reducing unnecessary side effects.

We will see increased awareness of the long - term effects of pediatric cancer treatment, and what can be done to mitigate those.»

The data presented in this article suggests that tumor subtype needs to be taken into account during treatment design as blocking angiogenesis and therefore increasing tumor hypoxia may be beneficial in the treatment of ER - α — negative breast cancer but could have catastrophic effects on ER - α — positive breast cancer.

Analysis of escape latencies (Figure 3B) during training indicated significant effects of aging and, possibly, rapamycin, such that escape latencies were increased in aged mice and were decreased by rapamycin treatment (P = 0.0021, P = 0.0548, and P = 0.2419 for age, treatment, and age / treatment interaction, respectively, 3 - way ANOVA with age and treatment as between - subjects factors and training day as within - subjects factor).

Myelosuppression is a well - established side effect of current AML therapies, with prolonged events leading to an increased risk of infections and death.44 Consequently, therapies that preferentially kill leukemic cells over normal bone marrow cells are urgently required, and the overexpression of CD123 on AML leukemic stem cells and blasts compared with normal hematopoietic cells contributes to its attractiveness as a therapeutic target in this disease.6, 45 However, severe myelosuppression and myeloablation have emerged for some investigational CD123 - targeted treatment modalities.

A potential explanation for the secular trend may be that while improved treatment for cardiovascular risk factors or complicating diseases has reduced mortality in all weight classes, the effects may have been greater at higher BMI levels than at lower BMI levels.12 Because obesity is a causal risk factor for hypertension, diabetes, cardiovascular disease, and dyslipidemia,15,19 - 22 obese individuals may have had a higher selective decrease in mortality.18 Indirect evidence of this effect is seen in the findings as the deaths occur at similar time periods in the 3 cohorts, but cohorts recruited at later periods have an increase in the BMI associated with the lowest mortality, possibly suggesting a period effect related to changes in clinical practice, such as improved treatments, or general public health status, such as decreased smoking or increased physical activity.

What makes the benefits of testosterone enanthate so unique is that a once a week treatment can increase the amount of bioavailable testosterone in a man's body to support each of these functions with little to no side effects.

A study has also revealed double the increase of risk of autism spectrum disorders linked to the use SSRI antidepressants in pregnancy, with the strongest effect linked to treatment in the 1st trimester.

A 2015 article in the International Journal of Biochemistry and Cell Biology sums up the findings of multiple studies on ketogenic diets and cancer with the following: «there is increasing evidence that the ketogenic diet may also be beneficial as an adjuvant cancer therapy by potentiating the antitumor effect of chemotherapy and radiation treatment.»

First, consider lifting weights to increase muscle mass as muscle naturally produces testosterone, boosting the effects of your testosterone treatments.

Enterolactone has also been found to increase the sensitivity of breast cancer cells to radiation, thereby potentially enhancing the treatment effects of radiotherapy.

The delicate balance between the human microbiome and the development of psychopathologies is particularly interesting given the ease with which the microbiome can be altered by external factors, such as diet, 23 exposure to antimicrobials24, 25 or disrupted sleep patterns.26 For example, a link between antibiotic exposure and altered brain function is well evidenced by the psychiatric side - effects of antibiotics, which range from anxiety and panic to major depression, psychosis and delirium.1 A recent large population study reported that treatment with a single antibiotic course was associated with an increased risk for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the gut microbiota in adult mice and increased exploratory behaviour and hippocampal expression of brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect on behaviour.

Because much of the peripheral damage of cancer treatment is caused largely by oxidative stress and inflammation, increasing the body's antioxidant defense systems will drastically reduce side effects and limit suffering by the patient.

The scientist in me hopes to see randomized, controlled trials comparing the ability of raw milk, pasteurized milk, UHT - treated milk, and milk - free diets to prevent and treat asthma, and comparing their effects with and without other nutritional treatments, such as the inclusion of liver, bone broth, and other nutrient - dense foods, and dietary or lifestyle interventions aimed at increasing the metabolic rate.

But, «the type of treatment effects reported in this study, even though the investigators referred to increases in levels of «hyperactivity,» were not the disruptive excessive hyperactivity behaviors of ADHD but more likely the type of overactivity exhibited occasionally by the general population of preschool and school age children.»

I use essential oils to increase the effects of my Reiki treatments.

Often times, patients will feel a sense of euphoria and overall sense of calmness and wellbeing following an acupuncture treatment due to the effect of acupuncture on increasing serotonin which allows patient to feel rested, relaxed, and happy.

One study, focusing on castor oil's effects on our lymphatic system, found a «significant» increase in the number of T - 11 cells within patients after performing a castor oil treatment.

Yoga can improve not only the quality of life after diagnosis, but it appears to diminish the side effects of surgery, radiation, chemotherapy, and other treatments, and may increase the odds of survival.

Though western medicine tends to write off these patients as a lost cause with «advanced maternal age,» with consistent treatment OM techniques can help to reverse the effects of aging and increase the likelihood of successful conception and healthy pregnancy.

This would lead us to believe fasting, exercise, and autophagy induction could prove to increase the effect of cancer treatment.