Sentences with phrase «effect of this treatment which»

Not exact matches

Furthermore, an early - stage study pumping up the dose of its hemophilia A treatment — which aims to be a one - time therapy for the rare blood clotting - related disease — appeared to hit its targets without serious side effects.

But researchers at the University of Aberdeen found that a treatment originally designed for fighting cancer and diabetes could melt away fatty arterial plaque with a single dosing and reverse the effects of atherosclerosis, which can lead to multiple heart problems.

CAR - T treatments, including competing products from Novartis rivals Kite Pharma and Juno Therapeutics, come with the risk of potentially deadly side effects such as cytokine - release syndrome (CRS), in which a glut of T - cell - assisting cytokines can cause high fever, low blood pressure, and problems with lung oxygenation.

And herein lies a very broad and «mushy middle,» says McKenna, with the effect, in many cases, being the same: «It's still using smaller - than - treatment doses, or sub-therapeutic doses of antibiotics,» which creates a literal breeding ground for resistant microbial strains.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

People refusing medical treatment because they think they can pray disease away, The demoralizing way religion makes you feel about yourself (I am a wretch, a sinner, a bad person by nature), the religious wars that have been fought for millenia, the self righteous passing laws based on THEIR beliefs (change to the pledge of allegience which now excludes anyone who does not believe in a fairy godfather, the change to the national motto that turned it into the lie «in god we trust», the bigotry that «my religion is the right one and you are wrong so I'll pray for you» kind of crap... don't you realize that it is insulting to me when someone says they will pray for me... its the same as saying I'm going to do something for you but there won't be any effect, so it is just a waste of time.

The social problem which has the most direct pernicious effect on mental health is the inadequate provision which our society makes for the treatment of the major mental illnesses.

As Tiebout pointed out, the direct treatment of the alcoholic's «runaway symptom» is essential, and it consists of methods by which the cycle of drinking to overcome the effects of previous drinking is blocked.

Much contemporary treatment of history has put just such an emphasis on anamnesis; much is said about the vital entrance of the historian into the past, a participation which has the effect of making that past come alive again in the present.

Further, buckwheat is the richest food source of D - chiro - inositol, which is known for its glucose - lowering effects and benefits for the treatment of diabetes.

After the patient has returned home from the hospital, the next stage of treatment is consolidation, in which patients receive several additional rounds of chemotherapy to build upon the effects of induction.

A large number of ovaries increases the chance of pregnancy, but unfortunately has also been associated with ovarian hyperstimulation syndrome (OHSS), which is sometimes called the most important side effect of fertility treatment.

We examined plots visually to see whether there was any evidence of asymmetry that might suggest different treatment effects in smaller studies, which may indicate publication bias (Harbord 2006).

Treatment with the use of medical cannabis also has shown adverse effects such as daytime sleepiness, which may lead to unintended consequences such as motor vehicle accidents.

«We hope that interventions to decrease macrophage activation early in HIV infection will decrease associated bone loss, which has become a major adverse side effect of HIV infection and its treatment,» Aldrovandi said.

Their results raise new possibilities for the management of diarrhea, which is often a side effect of melanoma treatment.

For men with intermediate risk prostate cancer, side effects at two years following radiation therapy (RT) were comparable for extremely - hypofractionated treatment, which was delivered in seven fractions across two and a half weeks, and conventional treatment of 39 fractions across eight weeks, according to research presented at the 58th Annual Meeting of the American Society for Radiation Oncology (ASTRO).

No major toxic effects were observed, and the patient «was able to survive a much longer period than expected with an improved quality of life, which is clearly attributable to the treatment with 3BP,» the scientists concluded.

Cochran says the only side effect was mild bleeding in one of the six, which stopped when tPA treatment was also halted.

Ms Koechlin, Professor Philippe Autier and colleagues used statistical models to work out whether current cancer death rates were due more to the effects of age, the year of birth (which takes into account exposure to cancer - causing agents such as sunshine during early life), or to the recent introduction of new medical technologies or treatments.

At most centers, treatment for inflammatory bowel disease (IBD) is limited and usually takes patients down one of two routes: steroids or medication, which can often lead to life - long side effects.

«Once we understand how the brain systems producing the positive / euphoric and negative / anxiety effects of the drug interact, we might be able to produce treatments that address the balance between these two opposing actions, both of which serve as strong driving forces.

The researchers gave rats with liver cancer either the LDL - DHA nanoparticles or control treatments of LDL without DHA, which were expected to have no effect.

With support from pharma, we can refine these molecules over the next 10 - 20 years to develop anti-aging treatments which don't have the adverse effects of cancer drugs.»

Since neither the patients nor the researchers knew which treatment each person actually received, the true effect of the LFMS could be measured.

It is possible that medical advances over the past few decades in the treatment of type 2 diabetes, hypertension and high cholesterol levels have had a greater impact on people who are overweight — which increases the risk for these conditions — whereas the effect was much smaller in those of normal weight.

«New soft material could reduce complications for women suffering from urinary incontinence: Researchers have developed a novel implantable material which could reduce the number of debilitating side - effects that occur as a result of using a material that is too rigid for surgical treatment of incontinence.»

Furthermore, the report accuses the British Homeopathic Association (BHA), which had submitted evidence to the panel, of cherry - picking, and even, in one case actively misrepresenting, research into the treatment (a famous study that concluded its findings were «compatible with the notion that the clinical effects of homeopathy are placebo effects» was cited by the BHA as evidence of the treatment's efficacy.)

Researchers at the University of Sheffield have developed a novel implantable material which could reduce the number of debilitating side - effects that occur as a result of using a material that is too rigid for surgical treatment of incontinence.

According to Dr. Rosamilia, early treatment not only can reduce the pain and severity of the disease, but also can help prevent potential side effects like eye problems, infection, and a condition called post-herpetic neuralgia, which causes pain, numbness, itching and tingling.

«Our collaboration with scientists at Charles Gerhardt Institute was important to the success of this two - photon activated technique,» said Tamanoi, «which provides controls over drug delivery to allow local treatment that dramatically reduces side effects.»

However, if SSRIs had indeed acted merely by means of a placebo effect, these drugs should not outperform actual placebo in clinical trials where patients have been treated with an SSRI or with ineffective placebo pills, and where neither the physician nor the patient knows which treatment the patient has been given until the study is over.

«A potential reason might be related to the effects of treatment, such as menopausal symptoms and lymphodoema, which might contribute to emotional distress.

«We would give this biologic — which has minimal side effects — to any patient we identify through a blood test as producing HE4,» he says, adding that oncologists have recognized that women with high levels of HE4 do not respond to treatment and their survival rates are lower.

Rokers says showing the effects of teaching people to use cues to three - dimensional motion that they are otherwise ignoring may ultimately help refine treatment for vision disorders such as blind spots or amblyopia («lazy eye») in which the brain can be trained to compensate for perceptual limitations.

«The advantage an optogentic approach has over other immunotherapies, which typically activate global immune responses, is that we now have the tools to closely monitor the dose and location of the treatment to mitigate potential side effects to healthy tissues.»

For most available T cell immunotherapies, T cells (which play a central role in defending the body against illness) are engineered to recognize and eliminate tumors, but their activity is not specifically controlled, leading to toxicity and unwanted side effects in patients as a result of inflammation or in some cases suboptimal response to treatment.

The research, which appears in the journal The Lancet Oncology, should aid efforts to reduce and better manage the late effects of cancer treatment.

«Yet many cancer survivors are living with difficult and persistent side effects of these treatments, which can be incapacitating.

According to researchers, antibiotic resistance and side effects limit the efficacy of the current treatments, which include benzoyl peroxide, retinoids, antibiotics and Accutane (isotretinonin).

This enabled us to examine whether the possible effects of rapamycin depend on the age at which treatment started.»

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

If, for example, the crucial effects of neutrinos were included in some detailed treatment, the computer simulations could only be performed in two dimensions, which means that the star in the models was assumed to have an artificial rotational symmetry around an axis.

Lithium treatment was associated with less thinning of gray matter, which suggests a protective effect of this medication on the brain.

The diagnosis and treatment of female cancers are known to affect fertility for several reasons: some chemotherapy regimens can cause damage to the ovary, and this can occur at any age; radiotherapy can also compromise female fertility through effects on the ovary, uterus and potentially those brain centres which control the reproductive axis.

The researchers believe that their software has the potential to help doctors to identify which of those patients are at low risk of suffering side effects and hence might benefit from treatment.

However, this study indicates that not all at risk patients show accelerated lung function decline, which may explain why, so far, the effect of various treatments of lung function decline has been difficult to establish.

«Identifying a cancer driver is crucial for cancer treatment because it allows the use of targeted therapies, which have less side - effects than conventional chemotherapy drugs, against a particular protein,» said Kurokawa.

Currently available treatments have only modest effects on the disease and its symptoms, which underlines the importance of identifying preventive measures.

Professor Sadler comments that this research could lead to new cancer treatments: «Cancer drugs with new mechanisms of actions which can combat resistance and have fewer side - effects are urgently needed.