Sentences with phrase «effect of treatment at»

Evaluate the effects of treatment at various stages and develop additional treatment plans, if required

Not exact matches

But researchers at the University of Aberdeen found that a treatment originally designed for fighting cancer and diabetes could melt away fatty arterial plaque with a single dosing and reverse the effects of atherosclerosis, which can lead to multiple heart problems.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Many laboratory tests were performed and chemotherapy — requiring intravenous punctures — was resumed, even though studies had shown that this type of cancer does not respond significantly, if at all, to drug treatment, and even though complications and side effects from the drugs were expected.

An at - home exfoliating treatment is a great way to ensure your skin is ready to soak up the hydrating effects of coconut oil.

Patients at the Comprehensive Cancer Center donated their sore mouths, and the result was what the Yale Alumni Magazine described as «a hot new treatment for debilitating side effects of cancer treatment.»

This was before Mackey had won a single Iditarod, let alone four straight; before he used what he calls his marathon style — catnapping as his sled moves and covering 100 - mile chunks at a moderate pace without prolonged rest, instead of sprinting from rest stop to rest stop like most other racers — to win an unprecedented double (the Yukon Quest, the world's other 1,000 - mile dogsled race, and just weeks later the Iditarod) not once but twice; before he became so dominant that slower competitors complained they had no chance to finish within five days of him (the requirement for an official place and a commemorative belt buckle); and before a rival pushed for drug testing at the 2010 Iditarod, suspecting that Mackey's secret was his prescription for medical marijuana to alleviate the side effects of cancer treatment.

And at this year's conference, sessions included «Avoiding Unnecessary Guilt When Breast - Feeding Does Not Happen,» «Medications & Mother's Milk,» «The Effect of Media Violence on Children» and «Complementary Treatments to Postpartum Depression.»

For cessation of exclusive breastfeeding at up to four to six weeks there appears to be differential treatment effect according to the number of support contacts, with four to eight contacts the most effective schedule.

For cessation of any breastfeeding at up to six months it appeared that support from non-professionals was associated with a broadly similar treatment effect to that for support from professionals (Analysis 2.1).

However, we noted that the introduction of nonbreastfeeding at 1 y, when the children were 15 mo old, was a significant main effect of the D treatment because 4 women who had not received the D treatment were still providing breastfeeding with complementary foods.

However there was some evidence that more pronounced treatment effects were associated with studies at higher risk of bias; this could potentially confound any differences between subgroups.

Believing the old word of mouth that having dental treatment during pregnancy can have adverse effects on the health of your baby, is exactly what will put you and your baby at risk.

We attempted to examine this by assessing the intensity of the intervention, and we found studies with four to eight visits to be associated with a more pronounced treatment effect on exclusive breastfeeding at final study assessment.

Again, there was some evidence that the treatment effect may be partly due to bias; sensitivity analysis including only those studies assessed as being at low risk of bias for allocation concealment showed that results still favoured the intervention group although the treatment effect was less pronounced in the studies at lower risk of bias (Analysis 1.8).

For cessation of exclusive breastfeeding at up to six months the treatment effect appears to be greater when the intervention was delivered by non-professionals (lay support) compared with professionals or mixed support (test for subgroup differences: Chi ² = 7.74, df = 2 (P = 0.02), I ² = 73.1 %; Analysis 2.2).

The President, who was speaking at the inauguration of the Lavender Hill feacal treatment plant, was also optimistic of a reduction in negative health effects associated with poor liquid waste disposal and management in the short to medium term.

Researchers looked at the effect of a 3 - day treatment of tetracycline, a commonly used antibiotic, on the amount of methane generated within the manure of cattle.

Treatment with zoledronic acid was associated with a 73 percent and a 65 percent reduction in bone loss relative to placebo at 12 weeks and 24 weeks respectively, an effect that lasted throughout the 48 weeks of the study.

«A significant body of research has resulted in a shift from thinking of placebos as just «dummy» treatments to recognizing that placebo effects encompass numerous aspects of the health care experience and are central to medicine and patient care,» said the article's coauthor Ted Kaptchuk, Director of the Program in Placebo Studies at Beth Israel Deaconess Medical Center (BIDMC) and Professor of Medicine at Harvard Medical School.

For men with intermediate risk prostate cancer, side effects at two years following radiation therapy (RT) were comparable for extremely - hypofractionated treatment, which was delivered in seven fractions across two and a half weeks, and conventional treatment of 39 fractions across eight weeks, according to research presented at the 58th Annual Meeting of the American Society for Radiation Oncology (ASTRO).

Immunotherapy doubles overall survival and improves quality of life, with fewer side effects, in a treatment - resistant and rapidly progressing form of head and neck carcinoma, reports a large, randomized international trial co-led by investigators at the University of Pittsburgh Cancer Institute (UPCI).

At most centers, treatment for inflammatory bowel disease (IBD) is limited and usually takes patients down one of two routes: steroids or medication, which can often lead to life - long side effects.

«Our preclinical data suggest that combining low doses of these inhibitors will enhance the clinical effects of both drugs as a potential treatment for patients with AML,» says the senior author, Feyruz V. Rassool, PhD, associate professor of radiation oncology at the University of Maryland School of Medicine (UM SOM) and a researcher at the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC).

«Interestingly, we also found that vitamin C treatment had an effect on leukemic stem cells that resembled damage to their DNA,» says first study author Luisa Cimmino, PhD, an assistant professor in the Department of Pathology at NYU Langone Health.

«This treatment is a new form of cell transplantation that utilizes the patient's own cells, so it does not require immunosuppressive drugs and, thus, avoids the side effects of those drugs,» says Scott Nyberg, M.D., Ph.D., a liver transplant surgeon at Mayo Clinic.

Even when Unger adjusted his model to account for the fact that not all patients may get the new treatment, and even when he lowered the effect of the new treatment to three, not five years, the model showed a benefit of at least 2 million years in nearly every simulation.

Researchers at New York Eye and Ear Infirmary of Mount Sinai showed that a microdose delivery system achieved a treatment effect comparable to a conventional eyedropper, while delivering less than four times the amount of drug.

«Our research has led to the development of a test that can detect patients that will benefit from treatment up front and spare those who are at lower risk from the side - effects of chemotherapy.

«Most researchers have relied on cell lines to screen the effect of drugs and other treatments including viruses,» said Dr. Cripe, who also is a professor at The Ohio State University College of Medicine.

Furthermore, older patients are at risk from the adverse side - effects of adjuvant treatments such as hormone therapy or chemotherapy.

Instead, researchers told the European Breast Cancer Conference that their findings suggest that extending screening programs to older women results in a large proportion of women being over-treated, and at risk from the harmful effects of such treatment, because these women were more likely to die from other causes than from any tumors detected in the early stages of growth.

At this stage, the aims of the trials would be modest, seeking only to assess whether the treatments have a measurable effect, rather than expecting dramatic clinical improvement of the patients» condition.

Further scientific investigation is warranted to determine how the drug achieves its effects as well as how they might be used in the treatment of «the ennui and anguish of impending death» as well as «alcoholism and other forms of drug addiction,» argues Charles Schuster, a neuroscientist at Wayne State University and a former director of the National Institute on Drug Abuse, in a commentary on the paper.

«The advantage of being able to deliver methotrexate in this targeted way is to be able to gain the benefits from this key treatment of RA, while reducing the risk of adverse effects that are more frequent at high doses,» concluded Dr Macor.

Researchers at the University of Sheffield have developed a novel implantable material which could reduce the number of debilitating side - effects that occur as a result of using a material that is too rigid for surgical treatment of incontinence.

New findings by a biomedical engineer and his team at the University of Houston (UH) raise hope for a new class of drugs to treat lupus that may not include the long list of adverse risks and side effects often associated with current treatments for this disease.

«Since several BACE1 inhibitors are currently being evaluated in clinical phase 3 trials for the treatment of Alzheimer's disease, the identification of potential side effects will be of great importance to ensure a positive clinical outcome,» said Dr. Jochen Herms, a Professor of translational brain research at Ludwig - Maximilians - University Munich.

A team of researchers at the University of Georgia has developed a non-invasive method of delivering drugs directly to cancerous tissue using magnetic forces, a form of treatment that could significantly reduce the toxic side effects of chemotherapy.

«Our collaboration with scientists at Charles Gerhardt Institute was important to the success of this two - photon activated technique,» said Tamanoi, «which provides controls over drug delivery to allow local treatment that dramatically reduces side effects.»

This review looked at the effects of adding antimicrobial drugs to this treatment.

Even at this stage, measuring the number of innate lymphoid cells in the blood makes it possible to provide a prognosis of the effects of treatment.

The paper, written by authors at King's College London and Baylor College of Medicine, reviews contraceptive devices available including those already used by military and aviation personnel, and calls for more research into the effect of hormone treatments on bone mineral loss in space.

The effect of hormone treatments on bone mineral density (BMD) is another issue for spaceflight, where astronauts lose bone at a much higher rate than on Earth.

This enabled us to examine whether the possible effects of rapamycin depend on the age at which treatment started.»

(A placebo is a «sugar pill» or «dummy» treatment that is given in research studies to compare effects of an actual treatment compared to no treatment at all).

The large study looked at the effects of antihypertensive treatment on the risk of dementia over a period of up to 24 years in 1262 older African Americans with high blood pressure who were cognitively normal at the onset of the study.

The diagnosis and treatment of female cancers are known to affect fertility for several reasons: some chemotherapy regimens can cause damage to the ovary, and this can occur at any age; radiotherapy can also compromise female fertility through effects on the ovary, uterus and potentially those brain centres which control the reproductive axis.

The researchers believe that their software has the potential to help doctors to identify which of those patients are at low risk of suffering side effects and hence might benefit from treatment.

However, this study indicates that not all at risk patients show accelerated lung function decline, which may explain why, so far, the effect of various treatments of lung function decline has been difficult to establish.