Sentences with phrase «effect on bone marrow»

As with FLV, feline immunodeficiency virus (FIV) often causes anemia in cats through its effect on bone marrow.

Not exact matches

Studies have shown that chlorophyll found in food or small purified amounts of chlorophyll have a favorable effect on red blood cell formation in the bone marrow.

That suggests that nutrition has a direct effect on the balance of bone and fat in the bone marrow.

Scientists have known about the beneficial effects of bone marrow transplants since the late 1960s, but «there really hasn't been much data available to explain what is going on,» says immunologist James George of the University of Alabama, Birmingham, an author of the new study.

On the flipside, targeting this growth factor or BCL - 2 could reduce NK cell numbers and offer potential therapies for immune disorders such as some types of autoimmune diseases, sepsis or graft versus host disease, a side effect of bone marrow transplants.

To gauge the effect off the loss of imprinting control on the maintenance of the quiescent hematopoietic stem cell pool, Venkatraman analyzed the numbers of quiescent, active and differentiated hematopoietic stem cells in mouse bone marrow.

Case Western Reserve research associate Amar Desai, PhD, worked between the Markowitz and Gerson laboratories to determine the effect of SW033291 on mice that had received lethal doses of radiation and then received a partial bone marrow transplant.

«The dose of transplanted bone marrow has strong and lasting effects on how HSCs specialize and coordinate their behavior,» said Rong Lu, senior author and assistant professor of stem cell biology and regenerative medicine.

They then used human stem cells derived from bone marrow that would normally become bone cells to test the effects of the nanoparticles on stem cell proliferation and differentiation.

The second branch of the combination therapy, the low - dose metronomic chemotherapy, was similarly found to exert its therapeutic effect through a novel, hitherto unrecognized mechanism: The metronomic chemotherapy turned out to not primarily target the tumor cells, but to act on the recruitment of yet another tumor - promoting cell population from the bone marrow.

Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or hematopoietic stem cell transplants.

The therapeutic potential of bone marrow transplantation (BMT) relies on the graft - versus - leukemia (GVL) effect, which is closely associated with graft - versus - host disease (GVHD), the major cause of morbidity and mortality after BMT (1 — 4).

Quyyumi says the research team checked whether patients» pre-existing levels of CD34 + cells in their bone marrow had a significant effect on their outcomes; they did not.

Another is to monitor the effects of transplanting telomerase - deficient but ex vivo telomere - extended bone marrow into late - generation, TMM - disabled mice, so as to be certain that the niche of such animals (or, by implication, aging humans) will support the homing, engraftment, and initial development and differentiation of such cells; the necessary research is underway now thanks to a SENS Foundation grant to Dr. Zhenyu Ju of the Institute of Laboratory Animal Sciences and Max - Planck - Partner - Group on Stem Cell Aging in the Chinese Academy of Medical Sciences, and research partner of prominent telomere biologist Dr. K. Lenhard Rudolph.

Myelosuppression is a well - established side effect of current AML therapies, with prolonged events leading to an increased risk of infections and death.44 Consequently, therapies that preferentially kill leukemic cells over normal bone marrow cells are urgently required, and the overexpression of CD123 on AML leukemic stem cells and blasts compared with normal hematopoietic cells contributes to its attractiveness as a therapeutic target in this disease.6, 45 However, severe myelosuppression and myeloablation have emerged for some investigational CD123 - targeted treatment modalities.

If vaccines can have the same effect in dogs and a dog gets sick because of vaccine - induced mutations in cells in its bone marrow, liver or lungs it will not pass those mutations on to its offspring.

There are dose limiting side effects on the liver and bone marrow and so these must be monitored closely by the attending veterinarian while receiving treatment.

Depending on the underlying cause, and severity, a variety of options may be available to alleviate the effects of anemia including iron supplementation, management of stomach ulceration, and the administration of erythropoietin to stimulate the bone marrow.