Sentences with phrase «effect on cancer cell»
«Once we identify candidate proteins, we can manipulate and test them for their effect on cancer cell metastasis,» says Klemke.
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To date, it was assumed that chloroquine increases the sensitivity of cancer cells to chemotherapy by means of a direct effect on the cancer cells.
Mouse fibroblasts, however, had no effect on the cancer cells.
The team demonstrated the efficacy of the system by analyzing the metabolic conversion in liver cells of Tegafur, a chemotherapeutic pro-drug, into the toxic metabolite 5 - fluorouracil and its subsequent effect on cancer cells.
FY26 has been shown to be more selective between normal cells and cancer cells than cisplatin — having a greater effect on cancer cells than on healthy ones.
«The LINK - A dependent HIF1 signalizing cascade and the consequent effects on cancer cells implicate LINK - A and LINK - A interacting kinases and receptors as promising therapeutic targets for TNBC.»
Lycopene's effects on cancer cell functions within monolayer and spheroid cultures.
In a commentary in the journal, Moss, Singleton and Frances Lennon, PhD, summarize results from multiple studies to argue that opioids — drugs like morphine or the body's own opioids, such as endorphins — appear to have a significant and direct proliferative effect on cancer cells, aside from their effect suppressing immunity.
«We know that this drug improves bone health, but there is also some evidence that it may actually have an effect on cancer cells, and the fact that this was seen in this population is very exciting.»
To determine whether or not the damaging effects on cancer cells would affect normal cells — which are already programmed normally for apoptosis — they doused both cancerous liver cells and normal liver cells with CVE to examine the process of inducing apoptosis, which involves creating DNA damage as a precursor.
These studies point to how supporting healthy cells with FWGE can have substantial effects on cancer cells.
The lead author Xiangin Shi, PhD., professor in the Graduate Center for Toxicology at the University of Kentucky said: «What everyone seeks is an agent that has an effect on cancer cells but leaves normal cells alone, and this shows that grape seed extract fits into this category.»
In addition to their antioxidant activity, apple polyphenols may have a profound effect on cancer cells.
Over the last couple of decades but as recently as this year (2015), studies have emerged that analyze sclareol's effect on cancer cells.
The flavonoid antioxidants in apples have anti-proliferative effects on cancer cells.
All extracts were found to have cytotoxic effects on the cancer cells, with the clove essential oil producing the highest cytotoxic effect.
Cinnamon's effect on cancer cells and tumor growth has so far only been studied in animals, but was found to be toxic to cancer cells and to cause cancer cell death.
Not exact matches
As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?
Phytic acid's chelating effect may serve to prevent, inhibit, or even cure some cancers by depriving those cells of the minerals (especially iron) they need to reproduce.17 The deprivation of essential minerals like iron would, much like other broad treatments for cancer, also have negative effects on non-cancerous cells.
You have probably heard a number of rumors about the effects of technology on your health; that having a cell phone next to your head can cause brain cancer, for example, or that pregnant women shouldn't stand near a microwave that is running because it may harm the fetus.
He also investigates the effects of 2HG inhibitors on cancer cells.
On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.
Fostamatinib's effect on microtubules seems to increase the stabilizing effect of paclitaxel, even in resistant cells, which in turn may prevent cancer cells from proliferating, says Yu Yu, Ph.D., a postdoctoral fellow at the Johns Hopkins University School of Medicine and co-author of the study.
Future research should not only compare how embryonic stem cells, iPS cells and adult stem cells differentiate, but focus on what effects the niche in which these cells will reside, when transplanted, will have on their characteristics, including tendencies to mutate into cancer cells, notes cell and stem cell biologist Olga Genbacev at the University of California, San Francisco, (U.C.S.F.) School of Medicine.
While testing the effect of many normal, non-cancerous, human cells on the sensitivity of cancer cells to chemotherapy, they found a specific sample of normal human skin cells that rendered pancreatic cancer cells resistant to gemcitabine.
The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.
This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.
The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.
The gold - iron oxide core - shell nanorods may be useful in cancer therapy, with MRI imaging enabled by the iron oxide shell, and local heating created by the photothermal effect on the gold nanorod core killing cancer cells.
In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostinis.
With a view to clinical studies (tests on humans) it is important to note that the effects on the tumor vasculature were even observed at chloroquine concentrations that had little effect on autophagy in the cancer cells.
The study found that combining the two drugs had an increased effect of killing of cancer cells, while individually, the drugs have considerably less impact on cell viability.
The researchers looked at the synergistic effects of the two drugs on packaged DNA inside cancer cells.
Ana Soto, professor of cellular biology at Tufts University School of Medicine, and her colleagues were studying the effects of estrogen on a breast cancer cell line.
Hyder further tested luteolin and its effects on subduing the migration of triple - negative breast cancer cells throughout the body.
The researchers have isolated the sesquiterpene lactone damsin from the plant and studied its effect on cancer stem cells in three different breast cancer cell lines.
They have also developed other analogues that show very good inhibitory effects on cancer stem cells.
The results show that they both have an effect on cancer stem cells.
Olaparib had no effect on tumors formed by breast cancer cells containing functional BRCA1 and BRCA2 genes.
She set up a lab dedicated to studying the effects of chemokines on cell death and cancer.
In this study, the researchers tested the effects of Olaparib on the tumors formed by human breast cancer cells injected into mice.
But there seems to be a powerful force in all cells that operates on its own clock, and understanding that force could give us a lot of insight into minimizing the effects of both cancer and aging.»
Choi's team wanted to see what effect the two compounds have on breast cancer cells.
«We only need to increase concentration beyond levels found in a healthy diet for an effect on prostate cancer cells.»
Cancer chronotherapy is based on the concept that the right time of treatment during the day could decrease side effects to normal cells while killing cancer Cancer chronotherapy is based on the concept that the right time of treatment during the day could decrease side effects to normal cells while killing cancer cancer cells.
The toxicity of chokeberry extract on normal blood vessel lining cells was tested and found to have no effects up to the highest levels used (50 ug / ml), suggesting that the cell death effect is happening in a way other than through preventing new blood vessel formation (anti-angiogenesis), a process that is important in cancer cell growth.
Sood and his team first studied the effects of stress hormones on human ovarian cancer cell anoikis in culture.
The authors believe theirs is the first study to show that mouse mammary gland tissues are sensitive to a mixture of 23 commonly used UOG chemicals, with dose - specific effects on tissue morphology, cell proliferation and induction of intraductal hyperplasias, an overgrowth of cells considered a marker for future breast cancer risk.
«The current study was designed to determine the effect of inhibition of platelet activation and function by aspirin therapy on colon and pancreatic cancer cell proliferation,» the researchers wrote.
Dr Bernardo Tavora, lead author on the paper from the Barts Cancer Institute, said: «This work shows that sensitivity to cancer treatment is related to our own body mistakenly trying to shield the cancer from cell - killing effects caused by radiotherapy and chemothCancer Institute, said: «This work shows that sensitivity to cancer treatment is related to our own body mistakenly trying to shield the cancer from cell - killing effects caused by radiotherapy and chemothcancer treatment is related to our own body mistakenly trying to shield the cancer from cell - killing effects caused by radiotherapy and chemothcancer from cell - killing effects caused by radiotherapy and chemotherapy.