They also found that this new compound does not have
an effect on the cell division of animal cells, and that cell division restarts in plant cells upon removal of the compound.
«Our palladium - catalyzed sequential arylation reaction has been highly useful to rapidly synthesize a variety of triarylmethanes to be used for testing
their effect on the cell division in plants,» says Nambo.
Dr. Minako Ueda, Dr. Masakazu Nambo of the Institute of Transformative Bio-Molecules (ITbM) of Nagoya University and their colleagues have reported in the journal Plant and Cell Physiology, on the development of a series of triarylmethane compounds, which were tested on plant cells to see
their effect on cell division.
Not exact matches
The researchers observed the
effect of the synthetically produced molecule, JK - 31,
on the growth and proliferation of a model human breast cancer
cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the
division of cancer
cells, and therefore inhibited the proliferation of the
cells.
«With the help of animal biologists, we found that chem7 had no
effect on budding yeasts and human
cells, which indicates that chem7 does not inhibit the
cell division of animal
cells.»
«We saw that chem7 had hardly any
effect on the shapes of the
cells and tissues, thus, suggesting that chem7 stops
cell division in plant
cells, but does not cause any severe damage to the shapes,» describes Ueda.
The researchers found that timing — specifically, the phase of the
cell division cycle that bacteria were in when exposed to the antibiotic — had a significant
effect on susceptibility.
But most of our 23,000 genes are involved in fundamental processes such as
cell division, and do not have any known
effects on our character.
By means of their mouse model, the hormone researchers from Ulm could prove that dexamethasone — mediated through the dimer function of GR — leads to the release of sphingosine -1-phosphate in the macrophages, a tissue hormone that fosters growth, migration and
division of
cells and has a stabilization
effect on inner vessel walls.
In order to investigate their specific roles, they used inhibitors of each protein to see their
effect on zygote polarization and asymmetric
cell division.
Simon's strategy is to compare the
effects of a drug
on a normal strain of yeast and a strain with a mutation in one of the many genes that affect normal
cell division - a property that is disrupted in cancerous
cells.
The key point is that this work demonstrates that MSC exert veto
effects on T
cells and it is significant in demonstrating that the mechanisms inducing MSC tolerance are not confined to patterns of cytokine secretion but extend to direct modulation of T
cell division.