Sentences with phrase «effect on the cells»

An acid condition has several adverse effects on cell metabolism, including impaired energy production, fluid accumulation and edema, and a likely increase in free radical production.

The researchers then found that, while the drug continued to inhibit FGFR activity in the resistant cells, its inhibition of FGFR signaling had no appreciable effect on the cells» survival.

The materials that pharmaceutical companies use to test drugs» effects on cells don't allow for three - dimensional vascularization, a network of capillaries that carry drugs and other materials throughout the body.

It belongs to a group of chemicals called reactive oxygen species (ROS), which scientists suspect to have a damaging effect on cells and their components.

They also found that this new compound does not have an effect on the cell division of animal cells, and that cell division restarts in plant cells upon removal of the compound.

«Our palladium - catalyzed sequential arylation reaction has been highly useful to rapidly synthesize a variety of triarylmethanes to be used for testing their effect on the cell division in plants,» says Nambo.

The technique, reported in July, isn't a cure, but it could help researchers better understand the condition's effects on cells and design treatments for some of its symptoms.

The team also tested hydrogel's effects on cells from cartilage and joints, finding that it appeared to be safe.

Both mirror - image counterparts had longer effects on cells than the existing drugs.

Dr. Minako Ueda, Dr. Masakazu Nambo of the Institute of Transformative Bio-Molecules (ITbM) of Nagoya University and their colleagues have reported in the journal Plant and Cell Physiology, on the development of a series of triarylmethane compounds, which were tested on plant cells to see their effect on cell division.

Scientists at The Scripps Research Institute (TSRI) have demonstrated the power of a new drug discovery technique, which allows them to find — relatively quickly and cheaply — antibodies that have a desired effect on cells.

«DNA methylation has an effect on a cell staying pluripotent or differentiating,» explained Associate Professor Yoshida.

The graph's caption claims that it shows a «dose - dependent» effect on cell growth — the paper's linchpin result — but the data clearly show the opposite.

The chemical is non-toxic in larger form, but has been found to have a more harmful effect on cells on the nanoscale.

Two new analyses of the male sex chromosome have concluded that its genes have vital, wide - reaching effects on every cell in the body

Many studies of bacterial toxins examine how toxins first enter cells and the effect on the cell, not precisely how the toxin changes — and is changed in — the intracellular environment.

The vectors also contained DNA bar codes, sequences that the researchers could look for later to determine which small RNAs were having a big effect on a cell's behavior.

In a quickly executed study that reflects the global public health threat posed by Zika, the researchers compared Zika's effect on cells known as cortical neural progenitor cells to two other cell types: induced pluripotent stem cells and immature neurons.

Thus, treatment with X4 - ZFNs of both wild - type and ccr5Δ32 CD4 + T cells confers stable cxcr4 disruption and a marked survival advantage in the presence of R5X4 - HIV and X4 - HIV in vitro without any detectable effect on cell growth or viability in the absence of HIV.

Zinc finger nuclease mediated knockout of ADP - dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism.

Differential interference of chlorpromazine with the membrane interactions of oncogenic K - Ras and its effects on cell growth.

Receptors can have many subtypes, each with a different response to the corresponding chemical and thus a different effect on the cell.

This allows computer - controlled stimuli to be applied to neurons in culture, and measures their effects on cell membrane conductance.

«We do think this has some therapeutic relevance, where an inhibitors of this enzyme would have effects on the cells we identified that tend to overexpress this enzyme,» says Sabatini, who is also a biology professor at MIT.

In all these in vitro assays, kahweol treatments were carried out under conditions (kahweol concentration and duration of treatment) that did produce no cytotoxic effect on cells.

They also discovered that the drug had a much stronger effect on the cells without PTEN because their mitochondria were consuming ATP «instead of producing it.»

This effect on cell survival was not endothelial cell - specific, since IC50 values for kahweol treatment of several human tumoral cell lines were similar to those obtained for HUVEC (results not shown).

Their effect on cell fate and function is far wider than we initially thought.

The breakthrough modification of CRISPR technology can become an invaluable tool in studying treatment effects on cells.

My laboratory also conducts fundamental research using genetics, biochemistry, cell biology and proteomics to define mechanisms of ECM assembly and turnover and their effects on cell behavior.

HGH has a bigger effect on every cell in our body than all the other hormones mainly because it's the cell generator.

The result is that it is harder and harder for the hormone to open the cell door, and therefore more and more of the hormone is needed each successive time you want to make an effect on the cell / genes.

When applied to humans and other animals, cytokinins have potent anti-aging effects on cells and tissues.

Add in some phytoestrogens — these are not true estrogens but the idea is that they exert a weaker estrogenic effect on our cells.

Miyake, T. Mori, A. Kii, T. Okuno, T. Usui, Y. Sato, F. Sammoto, H. Watanabe, A. and Kariyama, M. Light effects on cell development and secondary metabolism in Monascus.

Dr. Saul taught us to treat the whole body - not just the symptoms - to prevent and reverse disease, and to do this by eating fresh organic fruits and vegetables, as well as their juices, whole, sprouted grains, and raw nuts and seeds - living foods that exist in nature and have a profund healing effect on every cell in the body.

Amino acids have different effects on cells; some help them to grow and reproduce while others keep them healthy and true to the DNA blueprint embedded in the cell at its creation.

They are known for their effects on cell membranes and immune response.

Ginger extracts have also been shown to have anti-tumor effects on cells.

From another perspective (regarding effects on cancer): since estrogens have 1000 times stronger effect on cell proliferation than phytoestrogens, the overall effect may be positive (also shown in several studies).

Apparently not — one study found that resveratrol has a powerful preservative effect on cells.

Dr. Joseph suspects the findings are a result of blueberries» rich store of flavonoids — phytochemicals that have an effect on cell membranes.

When insulin attaches to the receptor, it has the same effect on the cell as when estrogen attaches to the receptor.

You can also do some testing that reflects the nutrient's effect on your cells, not just a level in your body by using Spectracell labs evaluation.

Carbohydrate availability and training adaptation: effects on cell metabolism.

It has also been said to have potent anti-ageing effects on cells (in both humans and animals).

BioActive is the use of biologically active compounds in the product and is also a term used in veterinary research, referring to the compounds that have an effect on cells and tissues — examples include fatty acids, flavonoids, choline, prebiotics and polyphenols.

Not exact matches

Doing so has a very direct positive effect on your biggest nerve [the sciatic nerve], which is your stress - reliever and what brings about cell regulation.»

Moreover, some of the best - known and biggest - selling franchises — Assassin's Creed, Splinter Cell, Mass Effect, FIFA and so on — have been born and bred in Canada.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).