Sentences with phrase «effect over time for»

The resulting alienation of the child from the parent creates degrees of diminished relationship between the child and the alienated parent in a manner which can result in loss of affection and a reduction in quality of life for that parent, and may create dysfunctional effects over time for the child.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

«Having spare time and perceiving control over how to spend that time (i.e. discretionary time) has been shown to have a strong and consistent effect on life satisfaction and happiness, even controlling for the actual amount of free time one has.»

Over time, as people became more and more aware of the effects commonly used products can have on the environment, plastic - happy clients who once cared mostly for cost and convenience morphed into savvy customers with real concerns about the impact polyethylene and other petroleum - based products have on the ecosystem.

Fees are extremely important to take into consideration when evaluating options for retirement, because the effects are compounded over a long time horizon, and high fees and costs can cause serious harm to your retirement savings.

The series of studies tested the effects of power hierarchies on team productivity by creating teams with either a mixed propensity towards leadership — in one case some participants were primed to feel powerful by thinking of a time they wielded power over others while others subjects were asked to envision a time they were bossed around before joining the group — or teams made up entirely of hard charging leadership types or participants primed for a meeker, go along, get along approach.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

What social influencer lists don't account for is the cumulative effect of influence a person achieves over time and in the «real world».

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

However, the effects could actually become slightly bullish over time as the recovery efforts pick up, and intriguingly, there is «potential for some sustained US onshore production curtailments.»

The same effect could have been achieved by temporary employment, as the Bible itself stipulates for Israelites (Lev 25:39)» @Chad «LOL you have ZERO understanding of the practice at the time, over 30 % of the Roman population was slaves.

Either they necessitate a deceptive «God», e.g. creating starlight «in transit» which means that for some light the star that supposedly sent said light would never have actually existed, or they would cause effect that should be evident but are not, e.g. temporarily fast starlight would effectively cook many things, such as life on earth, if the required light (and attendant gamma radiation) were compressed into a significantly shorter time frame (think of the radiation from the apparent 13 billion years of the universe arriving at the same time, or even over a 1000 years).

I personally think religion should not be a factor.No one should ask the candidates what their religious views are and they should never mention them.Their religious preferences have absolutely no effect on what type of leader they will be.Unless they are some kind of a religious fanatic.I think it's time for an atheist.There was not a Christian president for over the first 50 years of our nations existence.And, I do not think there has been one since.If you look it up you will find not one of our founding fathers were Christian.Not even Jefferson.I know he wrote the Jefferson bible, but, that's just because he, like the other founding fathers, did not believe Jesus to be of divine decent.So, he kept his philosophy while removing all the mystical and dogmatic concepts.

I would say guiding forces for me are not concretely one thing or another, but more of a culmination of many effects and experiences over time.

For our purposes, the medical and psychiatric therapies may be divided into three categories according to their purpose: (1) those therapies that aid in the physical rehabilitation of the person suffering from the effects of an acute binge and / or prolonged excessive drinking over many years; (2) those that help to keep the addictive cycle broken and thus maintain sobriety for sufficient time to allow other therapies to take effect; (3) those that aim at lessening the alcoholic's personality problems — both those that contributed to the causation of his addiction and those resulting from the interpersonal chaos of progressive alcoholiFor our purposes, the medical and psychiatric therapies may be divided into three categories according to their purpose: (1) those therapies that aid in the physical rehabilitation of the person suffering from the effects of an acute binge and / or prolonged excessive drinking over many years; (2) those that help to keep the addictive cycle broken and thus maintain sobriety for sufficient time to allow other therapies to take effect; (3) those that aim at lessening the alcoholic's personality problems — both those that contributed to the causation of his addiction and those resulting from the interpersonal chaos of progressive alcoholifor sufficient time to allow other therapies to take effect; (3) those that aim at lessening the alcoholic's personality problems — both those that contributed to the causation of his addiction and those resulting from the interpersonal chaos of progressive alcoholism.

«Over time, the effect on the reward centre in the brain is similar to what makes drug addicts go back for another line of cocaine.»

There remains a need for future research to particularly show the effects of sustained or longer - term exposures to food advertising and to test whether the observed increases in intake after acute exposures are not later compensated for and, therefore, could lead to weight gain over time (54).

While toasting on the tawa, make sure you toast them over low flame taking enough time for the crispy and crunchy effect and for even browning of the bread slices.

And to be fair, that tactic has been a very useful one for us in recent times as shown to such devastating effect when Manchester United came to the Emirates about a month ago and the game was over after 20 minutes following a three goal blitz.

If that's had a similar effect to when he did the Indy 500 and made you want to watch it for the first time, or if you're unsure over exactly what the Daytona 24 Hours is, then this handy guide should tell you all you need to know.

You can perfect the technique for some of these moves over a period of time but it will be fine to simply perform the movements as best as you can as it won't take you too long to master the moves and develop a 20 - 30 minute workout that should have a positive effect on your body.

Walking in a hunched over position for long periods of time can drastically effect your posture which can lead to some serious back problems down the line.

Individual growth curve models were developed for multilevel analysis and specifically designed for exploring longitudinal data on individual changes over time.23 Using this approach, we applied the MIXED procedure in SAS (SAS Institute) to account for the random effects of repeated measurements.24 To specify the correct model for our individual growth curves, we compared a series of MIXED models by evaluating the difference in deviance between nested models.23 Both fixed quadratic and cubic MIXED models fit our data well, but we selected the fixed quadratic MIXED model because the addition of a cubic time term was not statistically significant based on a log - likelihood ratio test.

So while there is general agreement that some children do have serious sensory challenges, the disagreement is over whether SPD should be considered an independent disorder, how far sensory issues go in explaining behaviors, and whether the treatment occupational therapists offer for sensory issues has any effect on a child's functioning over time.

Fever over 100.4 º F (38º C) during labor is five times more likely overall for women using an epidural; 44 this rise in temperature is more common in women having their first babies, and more marked with prolonged exposure to epidurals.45 For example, in one study, 7 percent of first - time mothers laboring with an epidural were feverish after six hours, increasing to 36 percent after 18 hours.46 Maternal fever can have a significant effect on the baby (see belofor women using an epidural; 44 this rise in temperature is more common in women having their first babies, and more marked with prolonged exposure to epidurals.45 For example, in one study, 7 percent of first - time mothers laboring with an epidural were feverish after six hours, increasing to 36 percent after 18 hours.46 Maternal fever can have a significant effect on the baby (see beloFor example, in one study, 7 percent of first - time mothers laboring with an epidural were feverish after six hours, increasing to 36 percent after 18 hours.46 Maternal fever can have a significant effect on the baby (see below).

As a child, I had meningitis and still suffer the after - effects of the illness at times, and I've done fundraising and awareness for Meningitis UK over the years.

Second, I tend to agree with your assumptions about mandates and obesity — for example, the regulations require that fat calories be limited to 30 percent of the meal but over the time period that's been in effect, we've only seen an increase, not a reduction, in childhood obesity.

The strongest research methods for psychological studies are: qualitative findings versus quantitative; experimental rather than descriptive or correlational; controlled - experiment, meta - analysis, and observation designs over archival, case study, computational modeling, content analysis, field experiment, interview, neuroimaging, quasi experiment, self - report inventory, random sample survey, or twin study; and prospective (where subjects are recruited prior to the proposed independent effects being administered) and longitudinal (where subjects are studied at multiple time points) rather than retrospective or cross-section study.

Having created a company to offer these keepsake videos (at a cost of # 200 a time), he was asked for his views: «A great deal of research has been done over the past 30 years to investigate if fetal ultrasound has any effect on the baby and there is no evidence whatsoever of harm.»

This time, we achieved a substantial majority in favour of law making powers, meaning that, for the first time in over 600 years, laws that effect only Wales are made only in Wales.

When the Saxbe fix was used for Hillary Clinton, who had the same problem, there was some debate over whether it would be valid, due to the timing of when the raise by the Executive Branch took effect compared to exactly when Clinton resigned from the Senate and when her term of service began at the State Dept.. The Constitutionality has nothing whatsoever to do with Clinton's personal actions and these particulars would hold for others too if the timing was similar.

- GDP per capita is still lower than it was before the recession - Earnings and household incomes are far lower in real terms than they were in 2010 - Five million people earn less than the Living Wage - George Osborne has failed to balance the Budget by 2015, meaning 40 % of the work must be done in the next parliament - Absolute poverty increased by 300,000 between 2010/11 and 2012/13 - Almost two - thirds of poor children fail to achieve the basics of five GCSEs including English and maths - Children eligible for free school meals remain far less likely to be school - ready than their peers - Childcare affordability and availability means many parents struggle to return to work - Poor children are less likely to be taught by the best teachers - The education system is currently going through widespread reform and the full effects will not be seen for some time - Long - term youth unemployment of over 12 months is nearly double pre-recession levels at around 200,000 - Pay of young people took a severe hit over the recession and is yet to recover - The number of students from state schools and disadvantaged backgrounds going to Russell Group universities has flatlined for a decade

The global scope of the study could help researchers set upper and lower limits for black carbon deposition and better account for the effects of photodegradation, a process by which sunlight alters the molecular composition over time.

The massive star Sirius, for example, is just over twice as far away as Alpha Centauri — but because it shines some 25 times brighter than our sun, it offers a stronger radiation - pressure braking effect, allowing light sails to approach at much higher speeds.

And once the El Niño is over, it might not be time for celebration, since it's likely to be followed by a strong La Niña, which will bring roughly opposite effects to the world's weather.

Its durable construction also prevents the Melt Mat from degrading over time, a problem observed with other passive methods of snow removal, such as spreading large amounts of soot particles over snowbanks for a similar effect.

This study, following real - life patients for up to ten years, shows now that these good effects do not diminish over time.

The results, however, show that valuing these behaviours actually has the opposite effect, with peer relations worsening over time for those kids turning to consumer - culture values.

By studying access to care and health outcomes for five years after health reform took effect in Massachusetts, the authors also were able to distinguish how access to care and health outcomes changed over time.

The report also took the Corps to task for failing to keep track of the effects of subsidence: In New Orleans, the ground sinks over time.

«We've been targeting traditional risk factors in public health campaigns for many years,» said Susan Cheng, M.D., M.P.H., study lead author and Assistant Professor of Medicine at Brigham and Women's Hospital in Boston, Mass. «We wanted to take a look at how well we've been doing over time at keeping these risk factors from causing heart and vascular disease — both by preventing the risks from occurring and by minimizing their effects when they do occur.»

In order to examine the trend of vulnerability over time, he normalised the losses to the year 2015 by examining the effect of historic events for today's conditions.

Over time, this has a significant effect on the composition of the local neighbourhood and makes the area less affordable for poorer families.

«We suggest studies that follow users over time and seek to answer the cause - and - effect questions surrounding social media use and risk for eating and body image concerns.»

Pound for pound, the effect of methane on climate change is more than 20 times greater than carbon dioxide over a 100 - year period, according to the Environmental Protection Agency.

The models included terms for time (age in years, divided by 10 so the coefficients yield effects of decline over 10 years), age cohorts (age at baseline in five year bands) to adjust for secular effects, and an interaction term between age cohort and time, separately in men and women.

I also hope that this research can be a model for future studies that continue to investigate climate change effects over time and space using the fossil record.

Dec. 18, 2017 - Lawrence Livermore National Laboratory (LLNL) scientists and engineers have developed a «brain - on - a-chip» device aimed at testing and predicting the effects of biological and chemical agents, disease or pharmaceutical drugs on the brain over time without the need for human or animal subjects.

The Livermore PK analysis showed that SiNPs were rapidly cleared from the circulatory system (the «central compartment» in PK models) and were distributed to various body tissues, where they persisted over the eight - week time course of the study, raising questions about the potential for bioaccumulation and associated long - term effects.

Computational biology researchers at Pacific Northwest National Laboratory developed a model for predicting what's happening during a stroke, how the process evolves over time, the potential outcomes, and the effects of different treatment options.