Sentences with phrase «effective against»

Since a drug is assumed to be effective against its target human pathology and since the vast majority of deaths in the developed world are from ageing - related causes, it is inappropriate to describe something as an anti-ageing drug unless one has good reason to believe that it will appreciably extend the life expectancy of those in the developed world who receive it.

There are two parts to this study: - Phase Ib: To determine the safety and side effects of increasing doses of IL - 2 in combination with pembrolizumab - Phase II: Once the maximum tolerated dose of IL - 2 is determined, additional patients will be treated to determine if it is effective against the cancer.

It later was shown to be effective against elephantiasis as well, and Merck agreed to donate it to developing countries.

Now, the same researchers have proven that this therapy may be effective against the types of aplastic anaemia caused by short telomeres.

It has proved to be effective against a variety of such diseases, in addition to river blindness and elephantiasis.

UTMB has already begun testing an antiviral drug developed by UTMB researcher Pei - Yong Shi to treat dengue fever to see whether it would also be effective against Zika.

Prof Ajit Lalvani from the National Heart and Lung Institute, who led the study, said: «New strains of flu are continuously emerging, some of which are deadly, and so the Holy Grail is to create a universal vaccine that would be effective against all strains of flu.»

In 1978, when a derivative of the compound from Omura's soil sample proved effective against a worm that infected horses, Campbell realized a related kind of worm was responsible for river blindness.

NIAID's biodefense research is integrated into its larger emerging and re ‐ emerging infectious diseases portfolio that uses sophisticated genomic and proteomic platforms focused on developing broad ‐ spectrum therapies effective against entire classes of pathogens.

«It also was effective against known drug - resistant strains of the HIV virus, making it a very promising candidate for further development into a new HIV drug.»

Light - activated nanoparticles make existing antibiotics more effective against heavily antibiotic - resistant microbes.

The vaccines are close to 100 percent effective against the strains of HPV they include.

New research into CAR - T cell therapy has revealed crucial mechanisms that could help the immunotherapy technique, which is currently only effective against blood cancers, be adapted for the treatment of brain tumors and other forms of solid cancers.

To address this growing problem, NIAID is funding and conducting research on many aspects of antimicrobial (drug) resistance, including basic research on how microbes develop resistance, development of new and faster diagnostics, and clinical trials designed to find new vaccines and treatments effective against drug - resistant microbes.

For a bactericide to be effective against HLB, it must be able to move within the plant, too.

IDRI's current vaccine candidate (a fusion of four recombinant proteins and IDRI's proprietary adjuvant) is effective against MDR TB strains.

Yet cancer metabolism, like everything else that happens in tumors, is very complex, and a therapy that's effective against one metabolic process may not work against another.

Although originally designed to fight colon cancer, the drug, sorafenib (Nexavar ®), proved much more effective against kidney cancer.

He said traditional drugs to treat tapeworm infection — which target the whole organism at the larval stage - might not have been effective against tapeworm cancer cells, and it's also unclear whether chemotherapy for normal human cancer cells could have helped shrink the tumors.

These research collaborations have the power to answer questions critical to improving cancer outcomes, such as how tumors develop drug resistance, and what treatments are most effective against particular genomic traits.

«The type of beta blocker we found to be effective against melanoma — pan beta blockers — was actually the least prescribed,» Schell said.

The criteria are based on the novelty of the scientific approach; phase of development; and data showing whether the product is technically feasible, safe and effective against TB.

Together the team will not only be able to provide clarity on which drugs are most effective against tumors with specific PI3K - pathway mutations, but how these specific mutations differentially affect how the pathway functions.

Now, the two - year, $ 1 million PCF Challenge Award will allow Hsieh and MSK co-primary investigators Dr. Yu Chen and Dr. Brett Carver to combine their expertise to determine which drugs are effective against tumors with specific mutations and identify biomarkers that will enable oncologists to pair prostate cancer patients with the most effective treatment regimens.

Niclosamide (5 - chloro - N -(2 - chloro -4-nitrophenyl)-2-hydrobenzamide) is a teniacide which is especially effective against cestodes that infect humans and many animals [14].

As demonstrated by the breadth of clinical trial involvement shown above, CCIR members are testing the utility of immune checkpoint blockade in lymphoma (shown by Dr. Allison to be effective against melanoma), genetic engineering in cell therapy (e.g., CD19, CXCR2, TGF - β DNR), and TLR agonists or IL - 2 in vaccine formulations as well as some novel combination therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotype.

SLIPS have previously been shown to be effective against bacteria and algae, but mussels represent a particularly intimidating foe.

The drug imatinib mesylate (Gleevec) is shown to be effective against chronic myelogenous leukemia (CML).

Surgery is effective against melanomas that are detected early, but the cancer spreads rapidly and once this has happened, most treatments fail.

To see whether these new particles could be effective against tumors, Youn and his team first injected them into the tail veins of four mice with brain tumors.

Urumin was specific for H1 strains of flu, such as the 2009 pandemic strain, and was not effective against other current strains such as H3N2.

In the nose, these cells could increase production of proteins that are typically abundant only in the intestines and that are particularly effective against pathogens such as S. aureus.

Only one vaccine has been licensed, and neither it nor any others in development today will be 100 percent effective against malaria infection, said lead researcher José A. Stoute, associate professor of medicine and microbiology and immunology.

The worm that causes river blindness appears to be developing resistance to the sole drug that's effective against it, a study in West Africa shows.

Pentamidine, when used with other antibiotics, was found to be particularly effective against two of the three pathogens which the WHO has identified as having the most critical priority for development of new antibiotics.

With better understanding, they may be able to develop more sophisticated vaccines that can be effective against more pathogens — those that differ as a result of genetic variations.

The vaccine, a DNA vaccine, is safer and more effective against Zika virus and could offer more affordable long - term protection, researchers said.

While a vaccine against the virus is recently available commercially, its effectiveness is limited as it is not effective against all the four dengue viral subtypes, and there are no alternative therapeutics yet.

They are also effective against a wide range of pests which attack fruit and vegetables.

A mixnet with onion encryption is effective against a passive adversary, which can only observe network traffic.

A team of Massachusetts General Hospital (MGH) investigators has discovered a new combination of drugs that may be effective against one of the deadliest cancers, malignant melanoma.

Therapies based on immune cells, which target particular tumor molecules, are more specific, but they are not effective against a variety of tumors.

An especially important property from the start was possibly that the mixture was effective against a wide variety of fungi, as no specialized pathogens in beewolves are known to have evolved resistance to these antibiotics.

Or it might be necessary to reformulate the vaccine to make it effective against dengue serotype 2, which would also require redoing the clinical trials.

Scientists have assumed that a vaccine has to be equally effective against all four serotypes, fearing that incomplete protection against any one could put vaccinees at risk for severe illness.

«We're taking what Mother Nature has given us in terms of molecules and antibodies, and we're leapfrogging the adaptive immune system, which is not very effective against HIV,» he says.

Antibodies with a high target - binding affinity are known to be effective against cancer.

The researchers tested the drug on mice with H. pylori infections from several different cell lines, and found that the drug was effective against the H. pylori while maintaining populations of healthy gut bacteria.

The drug works by inhibiting replication of the hepatitis C virus; researchers noted that both hepatitis C and Zika belong to the same viral family and bore strong structural similarities that could make sofosbuvir effective against the latter.

In 2002 he learned of the dire need for synthetic artemisinin, a compound derived from the sweet wormwood plant, which is 90 percent effective against the parasite that causes malaria and has few side effects (malaria kills some 3 million people a year).