Sentences with phrase «effective against a target»

One of the greatest challenges in modern medicine is developing drugs that are highly effective against a target, but with minimal toxicity and side - effects to the patient.

2005 - 2006 — Merck and GSK report that the two HPV vaccines made from viruslike particles are 100 percent effective against the targeted HPV strains.

Since a drug is assumed to be effective against its target human pathology and since the vast majority of deaths in the developed world are from ageing - related causes, it is inappropriate to describe something as an anti-ageing drug unless one has good reason to believe that it will appreciably extend the life expectancy of those in the developed world who receive it.

Not exact matches

Apple Inc.'s increasingly effective patent war against rivals like Samsung Electronics may mask its real target: arch-foe Google Inc..

It's clear that betting against the public is only an effective strategy in heavily bet games, and that bettors should be targeting games with extreme levels of one - sided public betting.

FPEEG, the All - Party Fuel Poverty and Energy Efficiency Group, is a coalition of cross party MPs and industry stakeholders committed to maintain awareness in Parliament of fuel poverty issues; to monitor and comment on progress against government's targets to eradicate fuel poverty; to advocate policies that deliver affordable warmth for vulnerable households with emphasis on improved domestic energy efficiency including effective thermal insulation alongside efficient and effective heating systems.

A big part of the problem with chemical weapons is that nobody wants to admit that something relatively effective against a civilian target can be comparatively so very simple, these are generally terror weapons.

I can't myself see how any MP who votes against the target will thereafter be able credibly to claim that they support an effective response to climate change.»

After the team establishes that a compound is effective against a particular target, they pass the project on to other teams.

«The findings also suggest that therapies targeting the immune system may be effective treatments against this disorder and possibly other forms of epilepsy,» said Nath.

«Genes may cause tumor aggressiveness, drug resistance in African - American prostate cancer: Research found many targeted therapies for prostate cancer may not be effective against tumors in African - American men.»

To make a compound work better against a specific disease target, medicinal chemists optimize the drug, tweaking its structure or physical properties to make it more effective and safer.

Additional research is planned in part to determine if targeting metabolism might also be effective against other respiratory viruses, including emerging respiratory viruses or others like respiratory syncytial virus, which causes life - threatening infections in infants.

In contrast to viral proteins, the host targets are less prone to mutations and thus drugs targeting them could be more effective against viruses, which mutate easily.

Prof. Raymond Kaempfer, the Dr. Philip M. Marcus Professor of Molecular Biology and Cancer Research at the Institute for Medical Research Israel - Canada (IMRIC), in the Hebrew University's Faculty of Medicine, explains: «Rather than targeting the bacterial pathogens, which can then mutate to develop antibiotic resistance, host - oriented therapeutics have the advantage of remaining effective even against infections with antibiotic - resistant strains.

Using virtual tissue technology, researchers at Indiana University have identified a potential new drug target in the fight against polycystic kidney disease, an illness with no effective FDA - approved treatment that affects 200,000 people per year in the United States.

Co-senior study investigator and cancer biologist Iannis Aifantis, PhD, says the study offers the first evidence that «drugs targeting and disrupting leukemia cells» microenvironment — or what goes on around them — could prove effective against the disease.»

By tracking and understanding which host cell pathways are manipulated by these T. gondii proteins, scientists can identify potential new targets to develop more effective therapies against highly aggressive solid tumors.

This has rendered it difficult to implement effective and target - specific measures against the contaminative source.

Because the vaccine causes the body to mount an immune response directed against a unique tumor, the therapy is much more effective than gene - targeted or more general chemotherapy alone.

The targets of these drugs were not know to be present in cancer cells and therefore no one had considered the possibility that these drugs might be effective against aggressive cancer types, says Professor Ivaska.

«Gauging attitudes and behaviors of those providers on the front lines with respect to PrEP is a key pressure point in moving towards the routine use of effective, safe and well - targeted biomedical interventions in the fight against new HIV transmissions in the US.»

In theory, drugs targeting CXCR4 would be an effective addition to the arsenal against HIV.

There is no easy answer in our ongoing battle against obesity, but identifying the link between the drop in physical activity and increased BMIs, as well as the groups particularly affected, can assist public health officials to develop targeted, effective interventions.

Antibodies with a high target - binding affinity are known to be effective against cancer.

Therapies based on immune cells, which target particular tumor molecules, are more specific, but they are not effective against a variety of tumors.

Whilst a handful of these genes including DOT1L, BCL2 and MEN1 are already established therapeutic targets, most of them are novel and open up many new possibilities for developing effective treatments against the disease.

The FDA granted approval to olaratumab (LARTRUVO), a targeted antibody against the PDGFRα, for patients with soft tissue sarcoma (STS) for whom surgery and radiation therapy are not effective options.

The authors predict that an effective and targeted treatment of brain inflammation would help to restore brain function and protect against depression in multiple sclerosis.

He said traditional drugs to treat tapeworm infection — which target the whole organism at the larval stage - might not have been effective against tapeworm cancer cells, and it's also unclear whether chemotherapy for normal human cancer cells could have helped shrink the tumors.

«If we can come up with strategies to carefully target fat cells, then I think activating this pathway could be effective in the fight against obesity,» he says.

Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.

Stephan's foggy early morning brainwave illuminated an unexpectedly simple approach to making cell - based immunotherapy, in which cancer - targeting immune cells are enlisted to fight tumor cells, as effective against solid tumors as it has been against blood cancers like leukemia.

Our family's favorites include oregano spirits (which has proven effective against strep & scarlet fever), elderberry syrup (good for colds), and Happy (a supplement which targets unwanted organisms in the gut, and has proven to end stubborn stomach bugs in our house).

This provides excellent protection against heartworms, multiple gastrointestinal worms (hookworms, roundworms, and whipworms) as well as targeting two stages of the flea life cycle for effective flea control.

Containing a combination of two effective compounds to guard against tartar and plaque build up, the Oral Hygiene rinse also targets bad breath.

Keep in mind that each type of troops is effective against exact kind of creatures, so, for example, set archers against ground and air targets to protect the castle!

Modern organizations struggle with the scale, trusted nature, and lack of visibility of these platforms, and they're vulnerable against a new breed of highly - effective attacks outside the perimeter, ranging from targeted phishing and spoofed accounts to executive threats and data loss.

This approach goes against much contemporary thinking about the efficacy of psychological therapies and the general trend which has suggested that specifically targeted psychotherapies are more effective.2

To succeed, ensure your direct mail campaign competes against the mailers of top - producing agents and delivers an effective, targeted message.