Sentences with phrase «effective animal model»

An important step in developing effective treatments for human disease is finding an effective animal model of the disease to test potential therapies.

Until this discovery, there was no effective animal model of the early - pregnancy events that precipitate preeclampsia.

While the mouse study does not prove a direct connection between Zika infection and microcephaly, Rossi said, it does underscore the urgent need for effective animal models to further study the course of disease and its transmission.

Whilst we do have some effective animal models for some sexually transmitted infections (e.g. Chlamydia) it is not currently certain if the mouse is an effective model organism for the Zika virus.

Not exact matches

Researchers at the University of Missouri developed a new molecule in April 2014 that was found to be highly effective in animal models exhibiting SMA.

The laboratories also collaborated to successfully prove that reversing a protein deficiency through gene therapy is effective in improving and stabilizing SMA in a large animal model.

«While this is an effective treatment in our preclinical animal models, it is not a cure.

Because the researchers found that CTLA4Ig was effective in suppressing hepatitis in this study, they suggest that CTLA4Ig should be among the therapeutic options investigated further as a potential therapy for patients with severe acute hepatitis B. To this end, this animal model is useful for virological and immunological analysis of HBV infection.

«This shows that the nanoparticle - encapsulated drug is more effective in tumor reduction than the drug alone in these animal models,» says Le.

And at Boston College, biochemist David Newburg and his colleagues have found that another oligosaccharide called 2» - fucosyllactose is effective at warding off Campylobacter, cholera, and enteropathogenic E. coli — a frequent cause of diarrhea — in animal models.

Importantly, the development of a new animal model for Dravet syndrome based on reduced CHD2 expression might help to find effective treatments that could improve the lives of thousands of people suffering from Dravet syndrome and perhaps other genetic epilepsies.»

They go on to suggest that «lowering levels of TNF may be an effective strategy in improving host defense against S. pneumoniae in older adults,» and that, «although it may be counterintuitive to limit inflammatory responses during a bacterial infection, [some existing] clinical observations and our animal model indicate that anti-bacterial strategies need to be tailored to the age of the host.»

The star - shaped peptide polymer is also effective in killing superbugs when tested in animal models.

Testing in an animal model revealed that the electrically generated NO produced by both systems was as effective as tank - delivered gas in relieving pulmonary hypertension.

Unlike older vaccines, the new vaccine has already proven effective against pneumonic plague in animal models.

In addition, «since no animal models of fibromyalgia exist, our model provides a much - needed tool for understanding what makes current fibromyalgia drugs efficacious and for finding more effective drugs,» the researchers wrote.

Implicit in the duplicate - and - mutate model is the assumption that the toxins need to evolve rapidly to be effective because many venomous animals can be locked in an arms race with their toxins» targets.

But while many appear to be effective in animal models, most fail when tested in late - stage human clinical trials.

In an animal model of AML, treatment with a combination of FLT3 - and SYK - inhibiting drugs was significantly more effective than treatment with either drug alone.

The model uses an iterative approach to imitate animal evolution by introducing random mutations in the virtual pigeons, making them most sensitive to those volatile compounds that are most effective for navigation.

While optogenetics is used only in animal models, Gittis said she believes their findings could create a new, more effective deep brain stimulation protocol.

Mizoribine provides effective treatment of sequential histological change of arteritis and reduction of inflammatory cytokines and chemokines in an animal model of Kawasaki disease

Understanding cattle movement patterns as well as the connectivity of the various sectors of the U.S. cattle industry and incorporating these in the models would allow USDA Animal Plant Health Inspection Service (APHIS) Veterinary Services (VS) to develop more effective regulations and control strategies for various animal diseases, including boviAnimal Plant Health Inspection Service (APHIS) Veterinary Services (VS) to develop more effective regulations and control strategies for various animal diseases, including bovianimal diseases, including bovine TB.

Novel activators of this molecular pathway will be evaluated in a pre-clinical animal model of AMD to determine if treatment is effective in preventing or slowing the development of AMD - like pathologies.

Currently IDOBRU imports 66 Brucella vaccines from the Vaccine Ontology (VO; http://www.violinet.org/vaccineontology [21], including four licensed animal Brucella vaccines and 62 Brucella vaccine candidates that have been proven effective in laboratory animal models [33].

Animal models were developed using mice, hamsters, ferrets and nonhuman primates, and efforts to identify useful treatments and effective vaccines are ongoing.

Both recent experience with immunotherapy for clearance of Aβ in AD, and their own (and Prothena's) experience with AS - clearing immunotherapies in animal models, indicate that in order to be effective as disease - modifying agents when administered alone, therapies that remove proteinaceous aggregates from the brain must be initiated in the early clinical or even preclinical stages of the disease, before the burden of other forms of aging damage becomes entrenched.

Through «heart - on - a-chip» technology — modeling a human heart on an engineered chip and measuring the effects of compound exposure using microelectrodes — Lawrence Livermore researchers hope to ensure potentially lifesaving new drugs are safe and effective while reducing the need for human and animal testing.

The identification of effective compounds in vitro allows, after verification in animal models appropriate to consider the establishment of a clinical trial.

Through «heart - on - a-chip» technology — modeling a human heart on an engineered chip and measuring the effects of compound exposure on functions of heart tissue using microelectrodes — Lawrence Livermore National Laboratory (LLNL) researchers hope to decrease the time needed for new drug trials and ensure potentially lifesaving drugs are safe and effective while reducing the need for human and animal testing.

The Animal and Human Imaging Shared Resource enables Cancer Center investigators to execute high throughput, quantitative and noninvasive in vivo imaging studies on animal models, apply and validate MRI, optical, CT, PET, SPECT and ultrasound methods for noninvasive detection and characterization in small animals and incorporate emerging and clinical relevant quantitative MRI and PET protocols into Phase I, II and III clinical trials in a centralized, cost effective mAnimal and Human Imaging Shared Resource enables Cancer Center investigators to execute high throughput, quantitative and noninvasive in vivo imaging studies on animal models, apply and validate MRI, optical, CT, PET, SPECT and ultrasound methods for noninvasive detection and characterization in small animals and incorporate emerging and clinical relevant quantitative MRI and PET protocols into Phase I, II and III clinical trials in a centralized, cost effective manimal models, apply and validate MRI, optical, CT, PET, SPECT and ultrasound methods for noninvasive detection and characterization in small animals and incorporate emerging and clinical relevant quantitative MRI and PET protocols into Phase I, II and III clinical trials in a centralized, cost effective manner.

In pursuit of effective treatment of CM, clinical studies, postmortem analysis and animal models have been employed to understand the pathology and identify effective interventions.

The project has focussed on developing new animal models which use brain recording and behavioural tests to identify innovative and effective drugs for schizophrenia.

The group has further proved that administering growth hormone alleviated the NASH conditions caused by adult growth hormone deficiency, and treatments of GH and IGF - I were effective when applied to model animals with growth hormone deficiency.

Naringin and naringenin supplementation has proven to be effective for the treatment of metabolic syndrome and obesity in animal models [1].

Because of the effective use of the ketogenic diet in reducing seizures (see above), it has been suggested that it may also improve the clinical status in brain injury, especially by reducing the incidence of long - term consequences, such as epilepsy.79 Positive effects of a ketogenic diet have also been reported in reducing the cortical contusion volume in an age - dependent manner in an animal model of cortical injury, which is related to the maturation - dependent variability in brain ketone metabolism.92 These findings were also supported by the demonstration that a ketogenic diet reduced post-traumatic cognitive and motor function impairment, at least in a rat model.93

The really good news is that Bill Bruce, the architect of the Calgary Model, which is often referenced as effective, breed neutral animal management, will be in Victoria to attend the public hearing for this inquiry.

The nationâ $ ™ s animal welfare organizations are not promoting the only effective model at ending the killing of savable animals in shelters There are some like Alley Cat Allies and Best Friends, which agree with all the programs, but only the No Kill Advocacy Center is promoting it nationally as the key to ending the systematic killing of five million dogs and cats in U.S. shelters every year.

Our training model has been developed by our team of trainers who collectively have more than 20 years of experience in animal behavior and are committed to bringing the most effective techniques to our members.

No Kill is a humane, sustainable, cost - effective model that allows open admission animal control shelters to save all healthy and treatable animals, upwards of 99 % of all animals entrusted to their care.

New Hampshire provided a model for shelters that cost efficient, sustainable, is more effective, and doesn \» t require abandoning animals on the streets as Delaware has seen what can happen with the «No - Kill» effort here.

Thus, establishing an animal model for intraepithelial lesions is important for the development of both preventive measures and effective treatments and for better understanding of the etiology of the disease.

Although stem cell therapy is fairly new to veterinary medicine, it has been demonstrated to be an effective treatment in numerous animal models of disease such as osteoarthritis, tendon repair, fractures, muscular dystrophy, autoimmune problems, and other disorders.

In humans, both the HPA system and the autonomic nervous system show developmental changes in infancy, with the HPA axis becoming organized between 2 and 6 months of age and the autonomic nervous system demonstrating relative stability by 6 to 12 months of age.63 The HPA axis in particular has been shown to be highly responsive to child - caregiver interactions, with sensitive caregiving programming the HPA axis to become an effective physiological regulator of stress and insensitive caregiving promoting hyperreactive or hyporeactive HPA systems.17 Several animal models as well as human studies also support the connection between caregiver experiences in early postnatal life and alterations of autonomic nervous system balance.63 - 65 Furthermore, children who have a history of sensitive caregiving are more likely to demonstrate optimal affective and behavioral strategies for coping with stress.66, 67 Therefore, children with histories of supportive, sensitive caregiving in early development may be better able to self - regulate their physiological, affective, and behavioral responses to environmental stressors and, consequently, less likely to manifest disturbed HPA and autonomic reactivity that put them at risk for stress - related illnesses such as asthma.