Both recent experience with immunotherapy for clearance of Aβ in AD, and their own (and Prothena's) experience with AS - clearing immunotherapies in animal models, indicate that in order to be
effective as disease - modifying agents when administered alone, therapies that remove proteinaceous aggregates from the brain must be initiated in the early clinical or even preclinical stages of the disease, before the burden of other forms of aging damage becomes entrenched.
Not exact matches
For a century and a half, epidemiology has been an
effective strategy for tracing the root causes of infectious
disease outbreaks —
as John Snow demonstrated in 1854, when he painstakingly mapped cases of cholera in London and eventually traced them to a single contaminated well and water pump in the Soho district of the city.
While Viagra wasn't
as effective in treating cardiovascular
diseases as researchers had hoped, it was exceptionally potent at doing something else: opening up the arteries in the penis and flooding erectile tissue with blood.
Consider: the arsenal of
effective (and less risky) HIV medicines has ballooned, the stigma associated with the
disease has declined (although,
as activists note, much work remains to be done on that front), and awareness campaigns centered on HIV / AIDS have gone from what was a fringe movement just 30 years ago to a cause championed by top public figures and companies around the world.
All of these innovations
as well
as the discovery of rare
diseases and correct diagnosis are essential in providing
effective treatment and in some cases, avoid misdiagnosis.
Ionis Pharmaceuticals» mission is to develop safe and
effective RNA - targeting drugs for both rare and more prevalent
diseases and providing those drugs to the broadest group of patients
as quickly
as possible.
InvivoSciences will continue to contribute to the improvement of human health by establishing a new paradigm for discovering drugs that focus on
diseases with limited treatment options such
as cardiac fibrosis, scleroderma, and lupus in a time -
effective manner while remaining safe and cost
effective.»
Just
as arsenicals are
effective in an array of
diseases, but we know they're way to dangerous to use.
And since losing
as little
as 5 % of body weight improves a wide array of health factors, it is not so surprising that intermittent fasting is
as effective as continuous energy restriction when it comes to warding off heart
disease and diabetes.
«At the end of the day we do need traceability to be prepared for exotic
disease outbreaks such
as FMD but any system has to be cost -
effective and practical,» Mr Feldtmann said.
He also «promoted the product
as, among other things, an
effective treatment, cure and preventative for cancer, heart
disease, arthritis and diabetes, and
as a means of achieving substantial weight loss of up to 80 pounds in eight months,» according to a complaint filed by the Federal Trade Commission.
less than or equal to lamivudine Acquired Immune Deficiency Syndrome Antiretroviral therapy, usually means 1 - 2 drugs, used in early studies Antiretroviral zidovudine (also known
as ZDV) Breastfeeding Baby Friendly Hospital Initiative Breastfeeding and HIV International Transmission Study Combined antiretroviral therapy Centers for
Disease Control and Prevention Deoxyribonucleic Acid Exclusive Breastfeeding Enzyme Linked Immunosorbent Assay Food and Agrigulture Organization Fixed dose combination ART, e.g., lamividine, stavudine, and nevirapine Highly Active Antiretroviral Therapy, 3 or more drugs for more
effective treatment used in later studies Human Immunodeficiency virus International Atomic Energy Agency Infant feeding Infant and young child feeding Lopinavir cubic millimetre Mother - to - Child Transmission of HIV Non-governmental organization Nevirapine Polymerase Chain Reaction People Living with HIV Prevention of Mother - to - Child Transmission Replacement Feeding Ritonavir Ribonucleic acid, one of the three major macromolecules (along with DNA and proteins) that are essential for all known forms of life single dose NVP United Nations Agencies Joint United Nations Programme on HIV / AIDS United Nations Population Fund United Nations Commissioner for Refugees United Nations Children's Fund U.S. Agency for International Development World Alliance for Breastfeeding Action United Nations World Food Programme World Health Assembly WHO 2010 Guidelines on HIV and infant feeding World Health Organization Zidovudine (same drug
as AZT)
Breastfeeding support is the most
effective method of primary
disease prevention ranking far above supports such
as vaccinations (see The Lancet Child Survival series) and other interventions that we have available to us.
For those diagnosed with celiac
disease, research is revealing that the gluten - free diet is not
as effective as once thought, and that many people with celiac
disease do not completely heal after going gluten - free.
Dr Henrik Stotz said: «
As traditional methods of controlling crop
disease become less
effective, the need to breed new strains of crops with an inbuilt resistance to the
disease pathogens increases.
«Virtual house calls for chronic
diseases like Parkinson's are not only
as effective as in - person care but broader adoption of this technology has the potential to expand access to patient - centered care,» said Ray Dorsey, M.D., the David M. Levy Professor of Neurology at the University of Rochester Medical Center (URMC) and lead author of the study.
«Telemedicine
as effective as in - person care for Parkinson's
disease.»
With this technology, scientists could design and rapidly test new peptides to treat cancer and other
diseases,
as well
as more
effective variants of existing peptides, such
as insulin, Pentelute says.
The more diverse the genes of the MHC, the more
effective it is at conferring
disease resistance, and in a variety of animals individuals with diverse MHCs are more likely to be chosen
as a sexual partner.
Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such
as cancer, heart
disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more
effective.
«Furthermore, risk of ischaemic heart
disease can be reduced substantially by other lifestyle changes,
as well
as by drugs such
as statins shown to be
effective in primary prevention.»
The authors — Martin Llewelyn, a professor of infectious
diseases at Brighton and Sussex Medical School, and nine British colleagues — point to recent studies that have shown shorter courses of certain drug classes such
as quinolones are
as effective as the longer courses that have been recommended in the past.
As new
disease strains continue to develop, and globalization and travel make it easier to pass
disease across geographical borders, the ability to whip up huge quantities of
effective vaccine is becoming increasingly important.
As a result, infectious
disease experts currently try to find a balance between making sure drugs are
effective at knocking out harmful bacteria while keeping the treatment duration to the bare minimum required to stamp out an infection.
Although there is no cure for SMA currently, the National Institutes of Health (NIH) has listed SMA
as the neurological
disease closest to finding a cure, due in part to
effective drugs like the one developed in Lorson's lab.
The same technology is also likely to be
effective for infectious or other
diseases,
as well
as for tissue regeneration, Dong said.
For example, I teach most patients simple breathing techniques that come from yoga, which I have found to be strikingly
effective for an incredible range of conditions, from heart arrhythmia and high blood pressure to chronic digestive problems, such
as irritable bowel syndrome and reflux
disease.
Earlier this month, a network of researchers supported by the National Eye Institute (NEI) found that the drug Lucentis (ranibizumab) can be highly
effective for treating proliferative diabetic retinopathy, an eye
disease that can occur
as a complication of diabetes.
«It is expected that this study will lay the foundation for developing a new class of potent and
effective cancer therapies and the development of reagents targeting epigenetic events in immune - mediated
diseases as well
as other epigenetically - influenced
diseases,» said Alani, who also is chief of dermatology at Boston Medical Center.
Their approach, in which micro-liters of liquid containing a drug are instilled into the lung, distributed
as a thin film in the predetermined region of the lung airway, and absorbed locally, may provide much more
effective treatment of lung
disease.
As well as the smart contact - lens project, there is the Baseline Study, which aims to collect large amounts of data about people to better quantify health and disease, with the goal of earlier and more - effective preventive car
As well
as the smart contact - lens project, there is the Baseline Study, which aims to collect large amounts of data about people to better quantify health and disease, with the goal of earlier and more - effective preventive car
as the smart contact - lens project, there is the Baseline Study, which aims to collect large amounts of data about people to better quantify health and
disease, with the goal of earlier and more -
effective preventive care.
In the end, the identification of microbial species or metabolites that are altered in Parkinson's
disease may serve
as disease biomarkers or even drug targets, and interventions that correct microbial imbalances may provide safe and
effective treatments to slow or halt the progression of often debilitating motor symptoms.
«It showed the strong potential of using a NOX inhibitor
as an
effective treatment for this devastating
disease,» said Brenner.
The research also found that while Vitamin D can be
effective at preventing the onset of inflammation, it is less
effective once inflammatory
disease is established because
diseases such
as rheumatoid arthritis leads to vitamin D insensitivity.
The finding also suggests that an
effective treatment for one neurodegenerative
disease might work for other neurodegenerative
diseases as well.
«This creates entirely new conditions for our understanding of what happens inside the brain and for the development of more
effective treatments for
diseases such
as Parkinson's
disease and chronic pain conditions than can be achieved using today's techniques,» concludes Jens Schouenborg.
«It is important to the treatment of brain
diseases such
as Alzheimer's that we find a way of circumventing the brain's
effective defence.
«It's a significant threat
as the fungicides that are currently the only control for this
disease become less
effective.
The blood - brain barrier is an
effective barrier which protects the brain, but which at the same time makes it difficult to treat
diseases such
as Alzheimer's.
The compound suppresses an inflammatory pathway that is overactive in many autoimmune
diseases, suggesting that it may be
effective against multiple sclerosis, rheumatoid arthritis, lupus and other autoimmune
diseases as well
as psoriasis.
This extreme «hygienic behavior,»
as it's technically called, is an
effective way of containing
disease outbreaks in crowded insect colonies.
Over the past few years, Mark Schaller, a psychologist at the University of British Columbia, has been developing an intriguing theory that behavior can be just
as effective as microbiology at warding off
disease.
«Having an accurate overview of how different regions of countries are connected by human movement aids
effective disease control planning and helps target resources, such
as treated bed nets or community health workers, in the right places.
He adds that the findings, which are published in the online 26 September issue of Nature Medicine, may be applicable to other infectious
diseases such
as tuberculosis, for which no highly
effective vaccine exists.
But scientific and economic obstacles have stymied the development of
effective vaccines against many of the developing world's most deadly
diseases, such
as malaria and HIV
as well
as pneumococcus, the leading vaccine - preventable killer of children under the age of five.
Scientists hope that ribozymes might be
effective weapons against other autosomal dominant
diseases such
as Huntington's
disease and glaucoma.
As part of their work on nutrition and aging, they discovered that large doses of a vitamin called nicotinamide riboside were remarkably
effective in countering the progress of the
disease in animals.
But he also believes that medical researchers will overcome some of the thorny obstacles to safe and
effective therapies — just
as once seemingly insurmountable obstacles to kidney transplants were overcome — clearing the way for treatment of
diseases such
as Parkinson's, blindness, and immune disorders.
Protecting this microenvironment, or niche, has thus emerged
as a new route for the treatment of these
diseases, for which there is currently no fully
effective treatment.
«We need to do everything we can to find
effective drugs against the Zika virus,
as changes in travel and climate have caused more tropical
diseases to move into new parts of the globe,» said Kao, who has also spent 15 years studying the virus that causes hepatitis C.