Using the NSG mouse for confirmation is a vital step to bringing a more
effective combination therapy to the clinic for the benefit of leukemia patients.
Researchers have now found a way to map those alternate routes by studying individual cancer cells, suggesting approaches for developing more
effective combination therapies.
Not exact matches
The Bottom Line: The study's researchers believe that the
combination of cruciferous vegetables like cauliflower or broccoli with curcumin can be an
effective therapy to both prevent prostate cancer altogether and to prevent the spread of prostate cancer that has already developed.
Larry's work at Cascade has led him to believe that the
combination of neurofeedback and SI
therapies is very
effective for many of these children with dysregulated brains.
Some recent research shows that a
combination of both talk
therapy and antidepressants may be very
effective in treating postpartum depression sufferers.
less than or equal to lamivudine Acquired Immune Deficiency Syndrome Antiretroviral
therapy, usually means 1 - 2 drugs, used in early studies Antiretroviral zidovudine (also known as ZDV) Breastfeeding Baby Friendly Hospital Initiative Breastfeeding and HIV International Transmission Study Combined antiretroviral therapy Centers for Disease Control and Prevention Deoxyribonucleic Acid Exclusive Breastfeeding Enzyme Linked Immunosorbent Assay Food and Agrigulture Organization Fixed dose combination ART, e.g., lamividine, stavudine, and nevirapine Highly Active Antiretroviral Therapy, 3 or more drugs for more effective treatment used in later studies Human Immunodeficiency virus International Atomic Energy Agency Infant feeding Infant and young child feeding Lopinavir cubic millimetre Mother - to - Child Transmission of HIV Non-governmental organization Nevirapine Polymerase Chain Reaction People Living with HIV Prevention of Mother - to - Child Transmission Replacement Feeding Ritonavir Ribonucleic acid, one of the three major macromolecules (along with DNA and proteins) that are essential for all known forms of life single dose NVP United Nations Agencies Joint United Nations Programme on HIV / AIDS United Nations Population Fund United Nations Commissioner for Refugees United Nations Children's Fund U.S. Agency for International Development World Alliance for Breastfeeding Action United Nations World Food Programme World Health Assembly WHO 2010 Guidelines on HIV and infant feeding World Health Organization Zidovudine (same drug
therapy, usually means 1 - 2 drugs, used in early studies Antiretroviral zidovudine (also known as ZDV) Breastfeeding Baby Friendly Hospital Initiative Breastfeeding and HIV International Transmission Study Combined antiretroviral
therapy Centers for Disease Control and Prevention Deoxyribonucleic Acid Exclusive Breastfeeding Enzyme Linked Immunosorbent Assay Food and Agrigulture Organization Fixed dose combination ART, e.g., lamividine, stavudine, and nevirapine Highly Active Antiretroviral Therapy, 3 or more drugs for more effective treatment used in later studies Human Immunodeficiency virus International Atomic Energy Agency Infant feeding Infant and young child feeding Lopinavir cubic millimetre Mother - to - Child Transmission of HIV Non-governmental organization Nevirapine Polymerase Chain Reaction People Living with HIV Prevention of Mother - to - Child Transmission Replacement Feeding Ritonavir Ribonucleic acid, one of the three major macromolecules (along with DNA and proteins) that are essential for all known forms of life single dose NVP United Nations Agencies Joint United Nations Programme on HIV / AIDS United Nations Population Fund United Nations Commissioner for Refugees United Nations Children's Fund U.S. Agency for International Development World Alliance for Breastfeeding Action United Nations World Food Programme World Health Assembly WHO 2010 Guidelines on HIV and infant feeding World Health Organization Zidovudine (same drug
therapy Centers for Disease Control and Prevention Deoxyribonucleic Acid Exclusive Breastfeeding Enzyme Linked Immunosorbent Assay Food and Agrigulture Organization Fixed dose
combination ART, e.g., lamividine, stavudine, and nevirapine Highly Active Antiretroviral
Therapy, 3 or more drugs for more effective treatment used in later studies Human Immunodeficiency virus International Atomic Energy Agency Infant feeding Infant and young child feeding Lopinavir cubic millimetre Mother - to - Child Transmission of HIV Non-governmental organization Nevirapine Polymerase Chain Reaction People Living with HIV Prevention of Mother - to - Child Transmission Replacement Feeding Ritonavir Ribonucleic acid, one of the three major macromolecules (along with DNA and proteins) that are essential for all known forms of life single dose NVP United Nations Agencies Joint United Nations Programme on HIV / AIDS United Nations Population Fund United Nations Commissioner for Refugees United Nations Children's Fund U.S. Agency for International Development World Alliance for Breastfeeding Action United Nations World Food Programme World Health Assembly WHO 2010 Guidelines on HIV and infant feeding World Health Organization Zidovudine (same drug
Therapy, 3 or more drugs for more
effective treatment used in later studies Human Immunodeficiency virus International Atomic Energy Agency Infant feeding Infant and young child feeding Lopinavir cubic millimetre Mother - to - Child Transmission of HIV Non-governmental organization Nevirapine Polymerase Chain Reaction People Living with HIV Prevention of Mother - to - Child Transmission Replacement Feeding Ritonavir Ribonucleic acid, one of the three major macromolecules (along with DNA and proteins) that are essential for all known forms of life single dose NVP United Nations Agencies Joint United Nations Programme on HIV / AIDS United Nations Population Fund United Nations Commissioner for Refugees United Nations Children's Fund U.S. Agency for International Development World Alliance for Breastfeeding Action United Nations World Food Programme World Health Assembly WHO 2010 Guidelines on HIV and infant feeding World Health Organization Zidovudine (same drug as AZT)
On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in
combination with the ADC it proved itself
effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the
combination therapy.
This drug
combination may be a more
effective therapy for portal hypertension and warrants further clinical evaluation, the researchers wrote.
Dr Sian Clarke from the London School of Hygiene & Tropical Medicine, also a principal investigator in the research, said: «This study shows that rapid diagnostic tests can improve the use of artemisinin - based
combination therapies — the most
effective treatment for malaria — in drug shops, but it's not without its challenges.
This procedure's success demonstrates that the
combination therapy may be
effective against some rare genetic skin disorders.
A subsidy program intended to drive down the cost of lifesaving malaria drugs called artemisinin - based
combination therapies — now considered the most
effective treatment against the parasitic disease — was unveiled today in Norway.
The other study showed how using a
combination of drugs at increased potency could prove an
effective therapy against glioblastoma by inhibiting the PI3K and MAPK cellular pathways.
Many Africans get their malaria drugs in the private sector, from local pharmacies or village shops, where the latest and most
effective generation of drugs, the so - called artemisinin - based
combination therapies (ACTs), are often hard to find and expensive.
They will also investigate different
combination therapies, looking at those used for other conditions that may be
effective in reducing HIV - infected cells.
He cautions, however, that it took «15 years to get from that first antiviral to truly
effective, well - tolerated
combination therapy.
«
Combination therapy may be more
effective against the most common ovarian cancer.»
The researchers hope that these insights could lead to the design of better
therapies against metastasis and more
effective treatment
combinations that could prevent and slow both tumour growth and spread.
Clinical trials at other institutions have also shown that fixed - dose
combination is nearly five times more
effective at controlling high blood pressure than other drug
therapies.
The successful
combination of these two
therapies results in the growth of specialized vessels that deliver cancer - fighting immune cells to the tumor, potentially leading to more
effective treatments and longer survival periods.
«Our research adds weight to the idea that
effective antifungal drugs can target even those mitochondrial proteins that are highly conserved in humans and fungi, and that this could be a way to make a broad spectrum antifungal
combination therapy that would be less susceptible to resistance,» says Benjamin Vincent, a former graduate student in Whitehead Member Susan Lindquist's lab who is now a scientist at Yumanity Therapeutics.
«Since doxorubicin is one of the cheapest drugs that is
effective against many types of cancer but rarely used in colon cancer, the
combination therapy could be highly
effective in combating colon cancer while drastically lowering risk of cardiotoxic side effects.»
The results from our new study suggest that entinostat may enhance the anti-tumor efficacy of PD - 1 targeted
therapy through MDSC targeting, potentially providing an
effective combination treatment approach for patients with solid tumors, including lung and renal cell carcinoma.»
Gary Kobinger, one of the study authors, said it was the first time that a
combination therapy had been done in non-human primates that showed it could be 100 %
effective.
«Targeting with a humanized MAG - 1 can likely be
effective, especially when given in
combination with chemotherapy, for treating a deadly disease for which there is no
effective therapy.»
Two pharmacotherapies for smoking seem particularly
effective:
combination nicotine replacement
therapy (C - NRT) and varenicline.
New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially
effective combinations with CAR T
therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.
As demonstrated by the breadth of clinical trial involvement shown above, CCIR members are testing the utility of immune checkpoint blockade in lymphoma (shown by Dr. Allison to be
effective against melanoma), genetic engineering in cell
therapy (e.g., CD19, CXCR2, TGF - β DNR), and TLR agonists or IL - 2 in vaccine formulations as well as some novel
combination therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotype.
Dr. Mucke expects that an
effective Alzheimer's solution will include multiple
therapies to address the numerous proteins implicated in the disease — including amyloid - beta, apoE4 and tau — in much the same way that hypertension, cancer and severe infections often require treatment with
combinations of different remedies.
Together, our data suggest that clinical studies may be warranted to evaluate the therapeutic potential of ABL allosteric inhibitors and to determine whether
combination therapies that incorporate these compounds are
effective in treating metastatic breast cancer.
For antigen induced tolerance to be
effective,
combination therapies may also include an anti-inflammatory drug to create the appropriate environment for sustained suppression of autoimmunity.
Through long - established collaborations in Durban and Kimberley, these studies in particular seek to define: the immune responses that are
effective in control of HIV infection; the impact of HLA - mediated selection pressure on HIV at the individual and population level; the mechanisms of HIV non-pathogenicity; the nature and consequences of ontogeny of the virus - specific immune response; and finally the prospects for interventions including antiretroviral
therapy, alone or in
combination with broadly neutralising antibodies and / or T - cell vaccines, to achieve HIV eradication.
Pembrolizumab, which has already been shown safe and
effective as monotherapy for advanced, non-squamous non-small cell lung cancer (NSCLC), might also be an
effective component in
combination therapy for the disease.
Low - dose chemotherapy, radiation, or targeted
therapies given in
combination with immune checkpoint blockade may prove to be an
effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.
December 6, 2011 Drug
combination highly
effective for newly diagnosed myeloma patients, study finds A three - drug
combination treatment for the blood cancer multiple myeloma compares favorably to the best established
therapy for newly diagnosed patients, according to a multi-center study led by Andrzej Jakubowiak, MD, PhD, professor of medicine and director of the multiple myeloma program at the University of Chicago Medical Center.
Treatment (which may involve
therapy, drugs, or a
combination of the two) is very
effective.
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Nutritional ketosis has received a lot of attention by cancer researchers in recent years, and many studies show it has great potential not just as a form of cancer prevention but also treatment — in
combination with other treatments such as chemotherapy and radiation.16 Research is looking at whether non-toxic metabolic
therapies and drug cocktails may be just as
effective, with less toxicity.
By using a thoughtful
combination of conventional and natural
therapies, we work together to identify the most
effective and balanced approach to individual health issues and provide a safe, supportive and personal experience that you can trust.
In this workshop we will explore the many aspects of Holistic Healing and flower essence
therapy including: Dr. Edward Bach and the history of Flower Essences, understanding Bach's 38 remedies, how to combine flower essences to make
effective therapeutic remedies, working with chronic vs acute conditions, commonly used flower essences and
combinations for Transformational Healing, the art of case taking and finding out the key symptoms, working with intuition, distinctions between Flower Essences and other forms of energy medicine and much more.
Research has shown that all three methods have merit, although most health care professionals state that a
combination of medication and behavior
therapy is the most
effective.
Also,
combination therapy using the two agents may be more
effective in preventing diet induced obesity than either agent alone.»
However, some experts say that it may when used alone may not be very
effective in advanced cases so a
combination of proper herbs like spirulina, cat's claw and advanced
therapies like intravenous vitamin C should also be included.
The most
effective treatment for hot flashes, night sweats, and other menopausal symptoms is generally believed to be hormone
therapy, which entails taking estrogen, sometimes in
combination with progestin, to counteract the hormonal changes associated with menopause.
Combinations of different types of treatment, for example using Cosequin and acupuncture for maintenance
therapy and meloxicam on especially bad days, often proves more
effective than does any single
therapy alone.
It is also been inspiring to see the
combination of acupuncture and Chinese herbal
therapy work in chronic conditions where traditional Western
therapy has proven to be less
effective.
Depending on the circumstances, this might involve acoustic compression
therapy, electrical stimulation, laser
therapy, underwater treadmill, swimming, therapeutic ultrasound, acupuncture, veterinary spinal manipulation, massage, and a
combination of
effective exercises.
While we think the
combination of radiation
therapy and chemotherapy is likely to be more
effective than either on their own, it is possible to do one without the other.
Radiation
therapy in
combination with a non-steroidal anti-inflammatory drug has been shown to provide the most
effective pain relief in dogs, but the prognosis remains poor.
We are constantly striving to find the
combination of
therapies that is most
effective for each case, and as such, find it very beneficial to offer these
therapies side by side with traditional treatments tailored to your horse's unique situation.
Psychological research suggests that cognitive behavior
therapy (CBT), used alone or in
combination with medical
therapy, is the most
effective treatment for depression.