Sentences with phrase «effective drug targets»

In an attempt to discover more effective drug targets for influenza, scientists have recently identified several genes and molecules that are crucial for influenza virus replication.

But successful demonstration of SLC6A14 as an effective drug target for treatment of selective subtypes of cancer would provide new hope even for patients with other types of cancers.

Not exact matches

Ionis Pharmaceuticals» mission is to develop safe and effective RNA - targeting drugs for both rare and more prevalent diseases and providing those drugs to the broadest group of patients as quickly as possible.

One of the greatest challenges in modern medicine is developing drugs that are highly effective against a target, but with minimal toxicity and side - effects to the patient.

Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.

«If we could load these virus shells with a different cargo, say a drug, and target it to a particular place in the body, such as a tumor, it could then deliver the drug to just that specific location, making the drug more effective, or reducing side effects,» Lawrence said.

«We found that the protein isoforms expressed in African Americans with prostate cancer do not always respond to targeted therapies, whereas these drugs were found to be effective in European Americans with prostate cancer and do end up killing off the cancer,» said Lee.

«Genes may cause tumor aggressiveness, drug resistance in African - American prostate cancer: Research found many targeted therapies for prostate cancer may not be effective against tumors in African - American men.»

In the end, the identification of microbial species or metabolites that are altered in Parkinson's disease may serve as disease biomarkers or even drug targets, and interventions that correct microbial imbalances may provide safe and effective treatments to slow or halt the progression of often debilitating motor symptoms.

To make a compound work better against a specific disease target, medicinal chemists optimize the drug, tweaking its structure or physical properties to make it more effective and safer.

But researchers have had only a blurry picture of gp120's structure — not enough to design well - targeted drugs or mount an effective vaccine strategy.

The researchers believe that effective cancer therapy in the future will require the combined action of drugs that target both the tumor and its adaptive responses to initial therapies.

«This target can be used to develop a drug that would hopefully, combined with chemotherapy, be more effective and less toxic.»

He thinks the result will enable researchers to develop more effective antidepressant drugs with this specific target.

The reaction couples easily accessible carbonyl compounds (aldehydes and ketones) with ammonia, amines, or nitro compounds, and molecular hydrogen under industrially viable and scalable conditions, offering cost - effective access to numerous amines, amino acid derivatives, and more complex drug targets.

Drug providers will be able to recommend more effective instructions and application techniques to ensure that the spray reaches its target.

In contrast to viral proteins, the host targets are less prone to mutations and thus drugs targeting them could be more effective against viruses, which mutate easily.

Using virtual tissue technology, researchers at Indiana University have identified a potential new drug target in the fight against polycystic kidney disease, an illness with no effective FDA - approved treatment that affects 200,000 people per year in the United States.

New pharmacological approaches to target these changes will provide much needed and more effective treatments to reduce the power of drug - related associative memories that drive opiate addiction.

Co-senior study investigator and cancer biologist Iannis Aifantis, PhD, says the study offers the first evidence that «drugs targeting and disrupting leukemia cells» microenvironment — or what goes on around them — could prove effective against the disease.»

«Our research also shows that existing drugs can be repurposed to treat other diseases and once several potential drugs are found, we can redesign them to be more effective in combating their targeted diseases while reducing the side effects.»

Poirier hopes that with further funding and support, his studies will lead to the development of drugs targeted to specific genotypes, making them safer and more effective and reducing side effects.

«We have identified a novel therapeutic target for the treatment of severe influenza that is effective under conditions where known antiviral drugs fail to protect from death.»

For example, perhaps the amino acid interactions that stabilize the pump structure could be targeted by drug development efforts to block pump assembly or function, thereby rendering currently defunct antibiotics effective once more.

Triple - negative cancers are so called because they do not express receptors for the hormones estrogen and progesterone, nor for HER2 (human epidermal growth factor 2), and hence patients with these cancers are not candidates for treatment with modern hormonal therapies or the highly effective HER2 - targeted drug Herceptin (trastuzumab).

The targets of these drugs were not know to be present in cancer cells and therefore no one had considered the possibility that these drugs might be effective against aggressive cancer types, says Professor Ivaska.

«There are currently virtually no treatments for dilated cardiomyopathy targeted to genetic changes, so the finding that commercially available drugs may be effective for patients with childhood - onset, RAF1 - induced DCM is a remarkable advance,» said Bruce Gelb, MD, Director and Gogel Family Professor of the Mindich Child Health and Development Institute at Mount Sinai and senior author.

In theory, drugs targeting CXCR4 would be an effective addition to the arsenal against HIV.

In the Cancer Cell article, the researchers describe how various anticancer drugs, including cisplatin and the targeted therapy vemurafenib, which targets melanomas with the BRAF mutation, become more effective when co-delivered with phenformin.

«This breakthrough could lead to more effective therapies for women with this very common subtype of breast cancer and be the therapeutic target that the drug companies have been waiting for.»

«Identifying genetic mutations associated with disease risk is an effective way to better understand disease mechanisms, identify individuals at risk, and develop novel drug targets to treat the disease,» Dr. Peter added.

«At Exeter we are already developing specific psychological therapies, running clinical trials of novel drug approaches and using - cutting edge genetic techniques to identify new targets for safe and effective therapies and to allow us to use current treatments in a more focussed way.»

Current antimalarial drugs are becoming less effective as the parasite develops resistance to the drugs, making the search for new targets that can kill all species of malaria critical.

«Blocking known cancer driver unexpectedly reveals a new tumor - promoting pathway: Targeting both pathways with drug inhibitors more effective in stopping colorectal cancer growth.»

Many of these new drugs promise to be more effective because they target key pathways of cancer cells more specifically.

«Our research adds weight to the idea that effective antifungal drugs can target even those mitochondrial proteins that are highly conserved in humans and fungi, and that this could be a way to make a broad spectrum antifungal combination therapy that would be less susceptible to resistance,» says Benjamin Vincent, a former graduate student in Whitehead Member Susan Lindquist's lab who is now a scientist at Yumanity Therapeutics.

Traditionally, it has been considered that the more tightly a drug binds its target protein, i.e. the greater its binding affinity is, the more effective it will be.

«The problem is cancer cells are so diverse that even though the drugs, designed to target single cancer driving genes, often initially are effective, they eventually stop working and patients succumb to the disease,» Peter said.

The field has experienced monumental challenges developing new and effective drug therapies, not the least of which was the discovery that — until recently - clinical trials were conducted where up to 30 % of participants did not have the Alzheimer's disease - related brain change targeted by the experimental drug.

Reasons for the attrition rate included absence of effective drugs, timing of genomic testing in the course of a patient's disease, less - than - optimal access to targeted drugs or clinical trials, and patient and provider preferences.

The findings help explain, in part, why drugs treating RA vary in effect — why, for example, a treatment that might work in arthritic knees isn't effective in an arthritic hip — and provide a potential new template for precisely targeting treatment for each and every ailing joint.

«This suggests a mechanism by which drugs that target certain other neurological diseases may be effective.»

A new method has been developed to make drugs «smarter» using nanotechnology so they will be more effective at reaching their target.

C. Develop ways to overcome cancer's resistance to therapy Identify therapeutic targets to overcome drug resistance through studies that determine the mechanisms that lead cancer cells to become resistant to previously effective treatments.

Poly (ADP - ribose) polymerase (PARP) inhibitors are effective in a broad population of patients with ovarian cancer; however, resistance caused by low enzyme expression of the drug target...

When matched with patient records, iPSCs and iPSC - derived target cells may be able to predict a patient's prognosis and whether or not a given drug will be effective for him or her.

There, Dowdy's team found that siRNNs were significantly more effective at blocking target protein production than typical RNAi drugs — demonstrating that once siRNNs get inside a cell they can do a better job.

Hear about the Science Exchange's Reproducibility Initiative, which aims to reward high - quality, reproducible research and provide a mechanism for industry to identify robust new drug targets for the development of effective new therapies.

«This project could lead to new therapeutic targets and more effective and safer drugs for the disease.»

Zinc finger enthusiasts believe it's worth attempting to overcome the additional hurdles of developing DNA - targeting drugs, because of the chance that the end result may be safer and more effective.