The Walter Reed Army Institute of Research (WRAIR) and collaborators at the Beth Israel Deaconess Medical Center and Harvard Medical School have completed a promising preclinical study of two Zika vaccine candidates that suggests that
an effective human vaccine will be achievable.
A research team at The University of Texas at El Paso is one step closer to developing
an effective human vaccine for cutaneous leishmaniasis, a tropical disease found in Texas and Oklahoma, and affecting some U.S. troops stationed in Afghanistan and Iraq.
Forget carpet bombing with insecticides or spending millions to devise
effective human vaccines: Australian scientists have concocted a novel way to combat dengue fever, a deadly insectborne infection that sickens up to 100 million people every year.
Not exact matches
The method is relatively new, but far bacteria - based
vaccines have proven
effective: A seasonal flu
vaccine produced by VaxInnate successfully protected
humans in clinical trials, and the company's recently tested swine flu
vaccine immunized mice against the virus.
They believe a
vaccine that stimulates the body to produce more of these cells could be
effective at preventing flu viruses, including new strains that cross into
humans from birds and pigs, from causing serious disease.
If people are treated within two or three days of being bitten, the
human rabies
vaccine is highly
effective, and victims usually survive.
Already scientists at
Human Genome Sciences in Rockville, Maryland — a biotech company affiliated with Venter's research institute — have begun working on a more
effective vaccine against Haemophilus.
To develop an
effective vaccine, it is imperative to identify a suitable antigen structure of the virus which will create an
effective immune response in
humans.
If the
vaccine also proves safe and
effective in subsequent tests in
humans, it might be possible to mount a containment strategy similar to that used in the past against smallpox.
«Taken together, our findings provide substantial optimism that the development of a safe and
effective Zika
vaccine for
humans will likely be feasible,» they write.
Last year the FDA approved Gardasil, a
vaccine effective against four strains of
human papillomavirus (HPV) that cause 90 percent of genital warts and 70 percent of all cases of cervical cancer.
This is why it is so difficult for
humans to mount an
effective immune response and why it is challenging for researchers to develop
vaccines targeting the HIV envelope proteins,» Dr. Blanchard says.
«Taken together, these two studies suggest that the new scalable
vaccine formulation is likely to prove as
effective as the original formulation — which would make it the first protective TB
vaccine in
humans since BCG, which was introduced almost a century ago,» said Professor Ajit Lalvani, Director of the Tuberculosis Research Centre, National Heart and Lung Institute, Imperial College London and a member of the DAR - 901 development team.
The findings offer much - needed strategies for monitoring the emergence of dangerous bird flu strains capable of infecting
humans and for developing more
effective vaccines.
If
effective in
humans, the
vaccine could help control a dangerous form of pneumonia that mainly afflicts hospitalized patients and individuals with cystic fibrosis.
«Investigational
vaccine protects cattle from respiratory syncytial virus: Study provides model for developing an
effective human RSV
vaccine.»
This new work suggests that anti-PD-1 antibodies might be equally
effective in treating hepatitis C and other persistent
human viral infections, says Christopher Walker, PhD, a senior author on the study and director of the Center for
Vaccines and Immunity at Nationwide Children's.
An Australian researcher has helped identify the kind of
human trial that is most
effective for testing Ebola
vaccines.
investigational
vaccine - a
vaccine that has been approved by the U.S. Food and Drug Administration (FDA) for experimental testing in
humans, but has not yet been proven
effective.
PHILADELPHIA --(April 19, 2018)-- The Wistar Institute and partners at the Perelman School of Medicine at the University of Pennsylvania, Inovio Pharmaceuticals, and GeneOne Life Science were recognized among the Top 10 Clinical Research Achievement Awards by the Clinical Research Forum for their ground - breaking phase 1 DNA - based Zika
vaccine research — the first trial of a Zika
vaccine in
humans, which proved safe and
effective.
Human challenge trials like this one are an extremely efficient way for scientists to tell whether a particular
vaccine is
effective, but they are rarely conducted because of the ethical dilemma of the risk it places on volunteers who are purposely exposed to a virus.
The development of a safe and
effective vaccine takes many years and needs to go through many different stages of testing, including work on cells, testing on animals and finally clinical trials on
humans.
He laboratory is also developing
effective and safe Brucella
vaccines with an aim for eventual
human use.
The mission of the Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPM) is to improve
human health by conducting basic and translational research that leads to the development of
effective diagnostic biomarkers,
vaccines, antivirals and therapeutics for emerging, re-emerging, neglected or rare infectious diseases.
In 2009, the RV144 Thai
vaccine trial provided the first evidence in
humans that a safe and
effective preventive HIV
vaccine is possible.
There is currently no
effective vaccine protecting
humans against TB.
The Army - led RV144 HIV
vaccine trial provided the first evidence in
humans that a safe and
effective preventive HIV
vaccine is possible.
«These findings certainly raise optimism that the development of a safe and
effective vaccine against Zika virus for
humans may be successful,» he said.
Progress towards the development of highly
effective vaccines for malaria has been frustratingly slow, but a distinctive bright spot for malaria
vaccine and immunology researchers is the availability of
human experimental models of P. falciparum - infection and malaria immunity.
Background: Plasmodium vivax is the most widespread
human malaria geographically; however, no
effective vaccine exists.
THURSDAY, Sept. 29, 2016 (HealthDay News)-- The
vaccine against
human papillomavirus (HPV) infection, which doctors believe causes most cases of cervical cancer, appears even more
effective than believed, a new study finds.
Thus, it unknown how
effective the
vaccine will continue to be in future years unless it is updated like the
human flu
vaccine.
And again like with
human vaccines, the more dogs that get vaccinated, the more
effective herd immunity becomes and the harder it will be for the virus to spread.
This group is devoting considerable
human and financial resources to determine the true scope of the problem, the exact cause and the most
effective treatment of
vaccine - associated sarcomas.
And even then,
human flu
vaccines aren't very
effective... in fact the Centers for Disease Control and Prevention (CDC) tracks flu
vaccine effectiveness each year and it's usually around 50 % to 60 %.
Scientists have been trying to develop a
human leptospirosis
vaccine for decades — one that's safe and
effective and which governments will license around the world.
Thyro - Cat administers radioactive iodine I - 131 therapy (which is also used for overactive thyroids in
humans) for feline hyperthyroidism in diagnosed cats as easily and quickly as a
vaccine, as it is injected just under the skin; and is entirely safe and
effective for your cat.
The virus is able to mutate and develop new strains, much like the
human flu, making
vaccines not always
effective.
(ref) A cocker spaniel of 14 years or a cat of the same age is about equal in age to a
human of 70 - 73 (a large dog like a rottweiler would reach that equivalent age at 10) Perhaps a booster vaccination at that age might be appropriate — even though
vaccines in the elderly tend to be less
effective.
Vaccines take time to reach an
effective state in the
human body, and some have to be administered in a series over a period of days or even weeks.