Sentences with phrase «effective immune response in»
These findings lead to the hypothesis that impaired immune responses in the elderly to infection or vaccination reflects dysregulation of immunoregulatory pathways and metabolic pathways, which work in concert to orchestrate an effective immune response in young healthy individuals.
https://wistar.org/
To develop an effective vaccine, it is imperative to identify a suitable antigen structure of the virus which will create an effective immune response in humans.
Not exact matches
«This research represents a big step forward in understanding why some tumors are more aggressive than others and being able to predict rationally which neoantigens will be the most effective at stimulating an immune response,» said Dr. Balachandran, a member of the David M. Rubenstein Center for Pancreatic Cancer Research at MSK, and corresponding author of the companion study in Nature.
On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.
Understanding the body's immune response to a given vaccine could help make better and more effective vaccines in the future.
«The effective immune response didn't happen in every tumor model we tested, so we still need to figure out exactly what triggered the tumor shrinkage and how to predict which tumors will shrink in response to virotherapy,» said Leddon, who is also working toward her medical and doctoral degrees at the University of Cincinnati.
«We are pleased to have demonstrated such a potent and durable immune response to the vaccine,» said the study's lead author, Sita Awasthi, PhD, a research associate professor of Infectious Diseases at Penn. «If found effective in clinical trials, the vaccine will have a huge impact on reducing the overall prevalence of genital herpes infections and could reduce new HIV infections as well, especially in high - burden regions of sub-Saharan Africa.»
The new findings explain why DCs are not effective in executing a specialized process that is required for inducing antitumor immune responses and effective cancer immunotherapy.
It may be that PM2.5 causes damage to the airway so that a virus can successfully cause an infection or that PM2.5 impairs the immune response so that the body mounts a less effective response in fighting off the infection.
Antiviral drugs can suppress the amount of HIV in the body to nearly undetectable levels, but only an effective immune response can eradicate the virus.
This discovery lays the groundwork for a better understanding of the role progenitor cells can play in immune system response and could lead to the development of more effective therapies for a wide range of diseases.
«Although data clearly indicate better immune responses and vaccine efficacy against both genital warts and cervical dysplasia when vaccination occurs before age 14, this study suggests that HPV vaccination may be effective in reducing abnormal Pap test results even after sexual debut,» explained co-author Rebecca Perkins, MD, MSc, assistant professor of Obstetrics and Gynecology at Boston University School of Medicine and a gynecologist at Boston Medical Center.
«We learned in this study that grabbing hold of these glycans can be a very important early step in an effective immune response to HIV, and with this knowledge, we believe we can design better candidate vaccines,» said principal investigator Dennis R. Burton, professor of immunology and microbiology at TSRI.
In their latest study, researchers at La Jolla Institute for Allergy and Immunology identified a key signal that drives the commitment of immature Tfh cells into fully functional Tfh cells and thus driving the step - by - step process that results in a precisely tailored and effective immune responsIn their latest study, researchers at La Jolla Institute for Allergy and Immunology identified a key signal that drives the commitment of immature Tfh cells into fully functional Tfh cells and thus driving the step - by - step process that results in a precisely tailored and effective immune responsin a precisely tailored and effective immune response.
«We have now shown that the allergic immune response shortens lipids in the skin, making them less effective at maintaining moisture and more susceptible to irritants.»
«Our findings suggest that different prostaglandins have different roles in antiviral immunity and that specific inhibition of PGE2 will be an effective therapy against influenza viral infection by boosting immune responses.»
Tissue - resident memory cells generate an alert state that attracts and reactivates the circulating memory cells, resulting in a faster and more effective immune response.»
These latter two cell types can mount effective immune responses to viruses and tumors; whereas, exhausted T cells fail and memory T cells, in particular, for long - lasting durable effects.
Unfortunately neither approach is totally effective, and in the case of dampening the immune response, can have significant drawbacks.
The vaccine, if effective, would be given in two doses, one to prime the immune system to recognize these dangerous invaders, and a booster shot of a different vaccine that would amplify the immune response.
Because hemagglutinin also happens to be the part of the flu vaccine that induces an immune response in people (it's the H in a virus name like H5N1), each mutation renders the vaccine less effective.
«However, the unexpectedly large proportion of maternal blood cells in the fetus made us think that perhaps it was the maternal, rather than the fetal, immune response that poses the real barrier to effective stem cell transplantation.»
A new paper published in the February 2018 issue of Immunity by La Jolla Institute for Allergy and Immunology (LJI) researcher Yun - Cai Liu, Ph.D., reports mechanisms used by a subgroup of ILCs, known as ILC2 cells, to undergo maturation required for them to mount an effective immune response.
Since immune responses to vaccines can differ around the world, these findings are encouraging for the development of an effective Ebola vaccine for Africa,» said Merlin Robb, M.D., Director for Clinical Research at the US Military HIV Research Program (MHRP), whose site in Uganda, Makerere University Walter Reed Project (MUWRP), conducted the study.
In this study, investigators identified a mechanism that boosts the ability of regulatory T cells to cause problems by blocking an effective anti-tumor immune response.
Through long - established collaborations in Durban and Kimberley, these studies in particular seek to define: the immune responses that are effective in control of HIV infection; the impact of HLA - mediated selection pressure on HIV at the individual and population level; the mechanisms of HIV non-pathogenicity; the nature and consequences of ontogeny of the virus - specific immune response; and finally the prospects for interventions including antiretroviral therapy, alone or in combination with broadly neutralising antibodies and / or T - cell vaccines, to achieve HIV eradication.
NIMML researchers employ advanced computational tools in combination with experimental and clinical studies to capture variation and diversity of immune responses, and develop safer, more - effective precision medicine treatments for infectious and immune - mediated diseases.
A role for miR - 155 in enabling tumor - infiltrating innate immune cells to mount effective antitumor responses in mice.
Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.
Immune Design is a new generation vaccine company built on emerging understanding of the role of dendritic cells in determining an effective immune response.
Evidence is accumulating that DHEA may be effective as a treatment for the immunological abnormalities that arise in subjects with low circulating levels of this hormone, including the impaired immune response of older individuals and immune dysregulation in patients with chronic autoimmune disease.93
If D levels are low or even undetectable, adequate and effective immune response to any infection in the body will be severely hampered.
Not only has it been shown in multiple clinical trials to be extremely effective at promoting a healthy innate immune response, I can also personally vouch for how well it works!
Regarding treatment for Canine Infectious Hepatitis, the virus will typically eventually run its course, but aforementioned supportive are sometimes useful in stabilizing the patient to enable the mounting of an effective immune response to hasten recovery.
Good animal care practices and nutrition assist dogs in mounting an effective immune response.
The risk of progressing to neurodistemper is less in adult dogs as they tend to mount more effective immune responses than puppies do.
Killed vaccines need to be repeated in order to be effective in many cases because they do not continue to stimulate an immune response by viral reproduction like modified live vaccines.
Abortive infections In some instances, a cat can mount an effective immune response against the virus and completely eliminate it, but these abortive infections are rare.
Cats may mount a good immune response and contain infection effectively, resulting in a «regressive infection» - the virus may still be present in some cells, but an effective immune response stops widespread replication of the virus.