If D levels are low or even undetectable, adequate and
effective immune response to any infection in the body will be severely hampered.
Not exact matches
«We are pleased
to have demonstrated such a potent and durable
immune response to the vaccine,» said the study's lead author, Sita Awasthi, PhD, a research associate professor of Infectious Diseases at Penn. «If found
effective in clinical trials, the vaccine will have a huge impact on reducing the overall prevalence of genital herpes
infections and could reduce new HIV
infections as well, especially in high - burden regions of sub-Saharan Africa.»
It may be that PM2.5 causes damage
to the airway so that a virus can successfully cause an
infection or that PM2.5 impairs the
immune response so that the body mounts a less
effective response in fighting off the
infection.
These studies may provide additional clues on important
immune responses to prevent HIV
infection if the regimens prove
effective.
These findings lead
to the hypothesis that impaired
immune responses in the elderly
to infection or vaccination reflects dysregulation of immunoregulatory pathways and metabolic pathways, which work in concert
to orchestrate an
effective immune response in young healthy individuals.
Through long - established collaborations in Durban and Kimberley, these studies in particular seek
to define: the
immune responses that are
effective in control of HIV
infection; the impact of HLA - mediated selection pressure on HIV at the individual and population level; the mechanisms of HIV non-pathogenicity; the nature and consequences of ontogeny of the virus - specific
immune response; and finally the prospects for interventions including antiretroviral therapy, alone or in combination with broadly neutralising antibodies and / or T - cell vaccines,
to achieve HIV eradication.
Our goal is
to understand the acute
immune response associated with viral
infections to better identify and interdict these pathogens
to increase blood safety, as well as
to capitalize
to access
to subjects identified at the earliest point of
infection to better understand the generation of
effective immune responses against acute and chronic viral
infections.
Development of a focused
immune response, possibly induced through vaccination, may be an
effective strategy
to promote protection
to Ct
infection.