Sentences with phrase «effective immune therapies»
Their discoveries have led to the development of effective immune therapies for several types of cancer.
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The long - term vision is to apply these technologies to other genetic diseases, such as sickle cell disease, and to explore applications in developing effective immune therapies for cancer.
Not exact matches
One setback for these therapies which use the body's immune system to fight cancers is that they are, at times, more effective in certain patient pools than others.
On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.
The research suggests that immune therapy for cancer might be more effective if combined with drugs that inhibit NF - kB.
«The findings also suggest that therapies targeting the immune system may be effective treatments against this disorder and possibly other forms of epilepsy,» said Nath.
Yet studies have shown single therapies targeting only one part of the immune system have been effective in only a small percentage of patients.
«While immune checkpoint blockade therapy is effective in many cancers, it has been less successful for this particular form of prostate cancer, which has motivated a search for targeted therapies that overcome this resistance.»
Researchers have designed a nanoparticle - based therapy that is effective in treating mice with multiple myeloma, a cancer of immune cells in the bone marrow.
«It is expected that this study will lay the foundation for developing a new class of potent and effective cancer therapies and the development of reagents targeting epigenetic events in immune - mediated diseases as well as other epigenetically - influenced diseases,» said Alani, who also is chief of dermatology at Boston Medical Center.
To help formulate effective therapies against MRSA, researchers need a better understanding of how the immune system can combat unyielding bacteria.
«Research into basic workings of immune system points to way of improving therapies for cancer: Differences in wiring of «exhausted» and effective T cells indicate possible gene - editing targets.»
But he also believes that medical researchers will overcome some of the thorny obstacles to safe and effective therapies — just as once seemingly insurmountable obstacles to kidney transplants were overcome — clearing the way for treatment of diseases such as Parkinson's, blindness, and immune disorders.
«If immune cell therapies for cancer or autoimmune diseases (like rheumatoid arthritis, for example) are going to be safe and effective alternatives to more traditional medications, we must gain control over the activity of the cells to reduce risks of toxicity to the patient,» said Roybal.
This discovery lays the groundwork for a better understanding of the role progenitor cells can play in immune system response and could lead to the development of more effective therapies for a wide range of diseases.
The new research indicates that, in addition to using powerful antibiotics to fight off infections in patients with sepsis, immunotherapy drugs that boost the immune system may be an effective therapy.
Because the vaccine causes the body to mount an immune response directed against a unique tumor, the therapy is much more effective than gene - targeted or more general chemotherapy alone.
The researchers are now looking at how ICOS signals can be altered to diminish autoimmune disorders and augmented for more effective vaccine development, and are beginning research on how ICOS signaling may benefit Chimeric Antigen Receptor - T cell (CAR - T) therapies, which involves engineering of patient's own immune cells to recognize and attack their cancers.
«Understanding how cancers suppress the immune system is the key to identifying more effective immuno - therapies,» said Brent Hanks, M.D., Ph.D., at Duke and senior author of the study.
And while new therapies have been effective in releasing the immune system's restraints to unleash the body's own cancer - fighting powers, they only work in about half of melanoma patients and often lose their potency as the cancer develops resistance.
The successful combination of these two therapies results in the growth of specialized vessels that deliver cancer - fighting immune cells to the tumor, potentially leading to more effective treatments and longer survival periods.
«Our findings suggest that different prostaglandins have different roles in antiviral immunity and that specific inhibition of PGE2 will be an effective therapy against influenza viral infection by boosting immune responses.»
Therapies based on immune cells, which target particular tumor molecules, are more specific, but they are not effective against a variety of tumors.
In further studies, they plan to explore the role of autophagy in immune reactions toward other tumor cell types, to determine whether such therapies might be effective in a broad range of cancers.
«We predict that immune checkpoint inhibitor therapy will be more effective for HPV - active tumors than HPV - inactive tumors.
As demonstrated by the breadth of clinical trial involvement shown above, CCIR members are testing the utility of immune checkpoint blockade in lymphoma (shown by Dr. Allison to be effective against melanoma), genetic engineering in cell therapy (e.g., CD19, CXCR2, TGF - β DNR), and TLR agonists or IL - 2 in vaccine formulations as well as some novel combination therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotype.
«These results are an exciting early indication that this gene therapy is well tolerated and effective in infants as young as 2 months old with this devastating inherited immune disorder,» said Ewelina Mamcarz, M.D., an assistant member of the St. Jude Department of Bone Marrow Transplantation and Cellular Ttherapy is well tolerated and effective in infants as young as 2 months old with this devastating inherited immune disorder,» said Ewelina Mamcarz, M.D., an assistant member of the St. Jude Department of Bone Marrow Transplantation and Cellular TherapyTherapy.
«These early results in infants reinforce hope that gene therapy will prove to be safe and effective at restoring immune function early in life,» said Brian Sorrentino, M.D., a member of the St. Jude Department of Hematology, who leads this study with Mamcarz.
Preliminary findings indicate gene therapy pioneered at St. Jude Children's Research Hospital is safe and effective for babies with a devastating inherited disorder that leaves them with little or no immune protection
Through long - established collaborations in Durban and Kimberley, these studies in particular seek to define: the immune responses that are effective in control of HIV infection; the impact of HLA - mediated selection pressure on HIV at the individual and population level; the mechanisms of HIV non-pathogenicity; the nature and consequences of ontogeny of the virus - specific immune response; and finally the prospects for interventions including antiretroviral therapy, alone or in combination with broadly neutralising antibodies and / or T - cell vaccines, to achieve HIV eradication.
Research from this team suggests that therapies targeting the vitamin D receptor will perhaps «unmask» the pancreatic tumors and allow the immune cells to reach them, creating the possibility that immunotherapies will be effective.
Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.
Gene therapy to replace the protein missing in Pompe disease can be effective if the patient's immune system does not...
The discovery, published in the Proceedings of the National Academy of Sciences the week of November 6, 2017, suggests ways to influence the function of Tregs and ultimately to make immune - related therapies more effective.
The chronic leukemias have very effective treatments in the form of biologic therapies (such as Gleevec for CML), which are designed to stimulate the body's immune system to target cancer cells.
One body of research found that music therapy can prove effective in reducing anxiety and stress, strengthening the immune system and facilitating faster recoveries from illnesses.
IV Vitamin Therapy has been used as effective therapy in preventative and anti-aging medicine in improving physical and mental performance, DNA replication, immune support, and reducing inflammation or oxidative stress at a cellularTherapy has been used as effective therapy in preventative and anti-aging medicine in improving physical and mental performance, DNA replication, immune support, and reducing inflammation or oxidative stress at a cellulartherapy in preventative and anti-aging medicine in improving physical and mental performance, DNA replication, immune support, and reducing inflammation or oxidative stress at a cellular level.
Some of these treatments such as Gerson Therapy work to strengthen and balance the immune system and take some time to be effective while other treatments, such as High Dose Vitamin C intravenous therapy, target cancer cells safely and work right away to decrease tumor load, allowing time for the nutritional program tTherapy work to strengthen and balance the immune system and take some time to be effective while other treatments, such as High Dose Vitamin C intravenous therapy, target cancer cells safely and work right away to decrease tumor load, allowing time for the nutritional program ttherapy, target cancer cells safely and work right away to decrease tumor load, allowing time for the nutritional program to work.
Vitamin C (mini C) Intravenous Therapy - Vitamin C, which has been used to treat Fibromyalgia, improve immune system function, and fight chronic fatigue, is a very effective IV nutrient.
Because IV Vitamin Therapy supports the immune system rather than attack it, it is effective when used as an adjunctive treatment.
Improving Stem Cell Treatment Success Researchers will manipulate the expression of immune markers on stem cells to develop safer and more effective therapies for horses with musculoskeletal injuries.
Researchers will manipulate the expression of immune markers on stem cells to develop safer and more effective therapies for horses with musculoskeletal injuries.
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