Sentences with phrase «effective in cancer cell»

It is effective in cancer cell samples and cell lines resistant to conventional therapies.

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Persin, a natural toxin found in avocados, appears so effective at killing breast cancer cells that it is being considered as a chemotherapy agent.

A particularly effective treatment against many cancers, platinum - based chemotherapy, has the unfortunate side effect of damaging the hair cells in the ear that are responsible for sensing sound waves, Goldrich said.

On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.

Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.

The study also suggests that targeting the machinery that makes cells mobile, rather than targeting the tissue - clearing process — which has been tested in patients but has not been very effective — may be a better treatment strategy to stop cancers from spreading.

The UZH scientists have now discovered an astonishingly effective solution to switch off all signals emanating from HER2 in the cancer cells at the same time.

Vitamin C is up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2 - DG, according to scientists in Salford, UK.

Frequent, low - dose chemotherapy regimens avoid this effect and may therefore be more effective at treating certain types of breast and pancreatic cancer, according to the murine study «Metronomic chemotherapy prevents therapy - induced stromal activation and induction of tumor - initiating cells,» which will be published online November 23 in The Journal of Experimental Medicine.

In a continuation of this work, Goldman is also using mathematical modeling to pursue the most effective dose of chemotherapy to induce the vulnerable transition state of the cancer cell demonstrated in this researcIn a continuation of this work, Goldman is also using mathematical modeling to pursue the most effective dose of chemotherapy to induce the vulnerable transition state of the cancer cell demonstrated in this researcin this research.

Pre-clinical studies have shown it to be effective in eliminating a number of different kinds of cancers cells, including cancer stem cells from human breast cancer patient biopsies.

Researchers have designed a nanoparticle - based therapy that is effective in treating mice with multiple myeloma, a cancer of immune cells in the bone marrow.

Researchers at Washington University School of Medicine in St. Louis have developed a nanotherapy that is effective in treating mice with multiple myeloma, a cancer of bone marrow immune cells.

«Our study results suggest a new drug cocktail that is effective in both human lung cancer cell lines and fly models,» says Cagan.

Multiplexed genetic screening for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker - guided treatment is cost - effective compared with standard chemotherapy treatment without any molecular testing in the metastatic non-small cell lung cancer (NSCLC) setting in the United States.

However, she argues that the results are a breakthrough in cancer research as it may be the first step towards effective treatment of cancer stem cells, i.e. the cells believed to cause metastases.

«Our study provides a cutting edge advance in the field of cancer immunotherapy and could specifically pave the way for more effective NK cell - based immunotherapies.

«Research into basic workings of immune system points to way of improving therapies for cancer: Differences in wiring of «exhausted» and effective T cells indicate possible gene - editing targets.»

«For example, we found that highly aggressive ovarian cancer cells are glutamine - dependent, and in our laboratory studies, we showed that depriving such cells of external sources of glutamine — as some experimental drugs do — was an effective way to kill late - stage cells.

One of these, UJ3, is as effective as the industry - standard drug Cisplatin in killing cancer cells in laboratory tests done on human esophageal cancer, breast cancer and melanoma.

In research published in BioMetals, UJ3 is shown to be as effective against human esophageal cancer cells, as a widely - used chemotherapy drug in use todaIn research published in BioMetals, UJ3 is shown to be as effective against human esophageal cancer cells, as a widely - used chemotherapy drug in use todain BioMetals, UJ3 is shown to be as effective against human esophageal cancer cells, as a widely - used chemotherapy drug in use todain use today.

In addition, cancer cells» susceptibility to these agents varies widely, and tumors often develop resistance to drugs that initially seem effective.

When taken separately in low doses, resveratrol and grape seed extract are not as effective against cancer stem - cell suppression as when they are combined together, according to the researchers.

Hematopoietic stem cell transplantation (HSCT), once considered an effective yet risky alternative to drug therapy for blood cancer, has become more accessible and successful in a wide range of patients as a result of major advances in transplant strategies and technologies.

Because it more effectively induces cancer cell apoptosis in p53 - deficient tumors, FL118 is especially effective against late - stage cancers, which usually lose functional p53 and are resistant to DNA - damage drugs.

The targets of these drugs were not know to be present in cancer cells and therefore no one had considered the possibility that these drugs might be effective against aggressive cancer types, says Professor Ivaska.

Yet none of the models may be effective in demonstrating the way the cancer signals to other cells that tell the disease to grow.

While initially effective at treating the disease, the drugs fail to prevent relapse in nearly all patients because of residual cancer cells that escape therapy.

In the Cancer Cell article, the researchers describe how various anticancer drugs, including cisplatin and the targeted therapy vemurafenib, which targets melanomas with the BRAF mutation, become more effective when co-delivered with phenformin.

While still early in development, stem and therapeutic cells may one day offer effective treatments against diseases, particularly cancer.

«We expect that the proposed treatment will be especially effective in advanced stages of ovarian cancers, where there are many cancer stem cells in the tumors that resist conventional drug treatment,» says Minko.

The antibiotic, Doxycycline, followed by doses of ascorbic acid (Vitamin C), were surprisingly effective in killing the cancer stem cells under laboratory conditions, according to the research published in the journal Oncotarget.

Last week, Lin Zhang, MD, an associate professor of Obstetrics and Gynecology, described in Science Translational Medicine, how his team treated therapy resistant cancer cells to renew their sensitivity to PARP inhibitors, a class of drugs that, when effective, prevent cancer cells from keeping up with DNA repair, causing them to eventually die.

This molecule plays an important role in some cancers and drugs that block it are already available to patients — but making drugs that are more effective and less damaging to healthy cells could lead to patients living longer and reduce side effects.»

The successful combination of these two therapies results in the growth of specialized vessels that deliver cancer - fighting immune cells to the tumor, potentially leading to more effective treatments and longer survival periods.

Several drugs, some used clinically today, have been found to be effective in regulating the growth of neural stem cells, including cancer cells

Researchers are hopeful that the approach they used in this study of neuroblastoma may prove effective against some of the many other cancers also characterized by a surplus of MYC - family proteins in tumor cells.

In cultured cells, drugs that inhibit Cdk1 prevented HIF - 1alpha levels from falling and restored its ability to halt cell division, suggesting they may be effective treatments for certain cancers.

The breakthrough technology uses a simple mechanical method that has been shown to be more effective in trapping cancer cells than the microfluidic approach employed in many existing devices.

Now, researchers at The Wistar Institute have discovered how STAT3 behaves in immature myeloid cells known as myeloid - derived suppressor cells (MDSCs), and they believe they have found the basis for a much more effective method of using STAT3 inhibitors to stop cancer progression in its tracks.

«Researchers build liquid biopsy chip that detects metastatic cancer cells in blood: More effective than existing microfluidic devices, the breakthrough technology.»

Researchers at Norris Cotton Cancer Center have found an antibody that may be used in future treatments for recurrent small - cell lung cancer, which currently has no effective thCancer Center have found an antibody that may be used in future treatments for recurrent small - cell lung cancer, which currently has no effective thcancer, which currently has no effective therapy.

«We expect that our targeted PARP1 inhibitors will be more effective at killing cancer cells while protecting important molecular pathways in normal cells,» Tulin says.

In further studies, they plan to explore the role of autophagy in immune reactions toward other tumor cell types, to determine whether such therapies might be effective in a broad range of cancerIn further studies, they plan to explore the role of autophagy in immune reactions toward other tumor cell types, to determine whether such therapies might be effective in a broad range of cancerin immune reactions toward other tumor cell types, to determine whether such therapies might be effective in a broad range of cancerin a broad range of cancers.

The scientists took the genes for the most effective liver cancer antigen receptors on those T cells, put those receptors on human T cells and the resulting engineered human T cells eradicated the cancer as well, without hurting normal liver cells, they report in the journal Hepatology.

In a May 2014 study, Nagrath and colleagues found that highly aggressive ovarian cancer cells were glutamine - dependent and that depriving the cells of external sources of glutamine — as some experimental drugs do — was an effective way to kill late - stage ovarian cancer cells in the laIn a May 2014 study, Nagrath and colleagues found that highly aggressive ovarian cancer cells were glutamine - dependent and that depriving the cells of external sources of glutamine — as some experimental drugs do — was an effective way to kill late - stage ovarian cancer cells in the lain the lab.

After all, cancer cells rely heavily on SRCs to delicately orchestrate a wide range of cellular events, so SRC stimulation might be just as effective as SRC inhibition at disrupting the balance of signaling activity in cancer cells.

These super-stimulants may be especially ray ban outlet effective in the realm of cancer, where the immune system is not responding to a stealthy threat. But in dealing with autoimmune diseases such as multiple sclerosis or inflammatory bowel disease, it is more necessary to rein in over-enthusiastic immune cells.

By understanding the survival factors that keep cancer cells alive we aim to develop new and effective drugs that can activate natural cell death or inhibit impaired survival mechanisms in tumour cells.

In cancer research, the «Cas -9-sgRNA» complex is an effective genomic editing tool, but its delivery across the cell membrane to the target (tumor) genome has not yet been satisfactorily solved.