Sentences with phrase «effective inhibitors of»

The identification of novel and effective inhibitors of YAP1 activity can be expected to have significant benefits as anticancer agents,» explained Chellappan.

6 - OXO is an effective inhibitor of the enzyme aromatase; however, it does not completely inhibit aromatase activities

It is promoted in bodybuilding to be an effective inhibitor of an enzyme known as aromatase which causes the conversion of testosterone into estradiol and androstenedione into estrone.

Ellagic acid is an effective inhibitor of lung and esophageal tumors in mice (Stoner).

Chrysin - Chrysin (5,7 - Dihydroxyflavone) is promoted in bodybuilding to be an effective inhibitor of an enzyme known as aromatase which causes the conversion of testosterone into estradiol and androstenedione into estrone.

Not exact matches

Effective PARP inhibitors are particularly sought after by drugmakers because of their potential to be used in combination with other types of cancer treatments to create new breakthroughs in treatments.

We need effective action from the Government on education, health, housing and the economy to tackle the root causes of the disadvantage and poverty which are key inhibitors to educational progression.»

To be effective and reduce recurrence of cancer in the prostate, researchers found that prescribing PARP inhibitors, a drug commonly used in breast cancer, alongside anti-hormone therapy treatment may benefit men with prostate cancer.

Until now, EGFR inhibitors have only been effective at treating the 10 to 15 percent of non-small cell lung cancers that have a variant of EGFR, but the two - drug combo could potentially work for all non-small cell lung cancers, explained Dr. John Minna, Director of the Hamon Center for Therapeutic Oncology Research and Professor of Internal Medicine and Pharmacology.

«It showed the strong potential of using a NOX inhibitor as an effective treatment for this devastating disease,» said Brenner.

The study, «AKR1B1 promotes basal - like breast cancer progression by a positive feedback loop that activates the EMT program,» which has been published in The Journal of Experimental Medicine, suggests that an inhibitor of this enzyme currently used to treat diabetes patients could be an effective therapy for this frequently deadly form of cancer.

Thus, a combination of MEK inhibitor given continuously with intermittent CDK4 / 6 inhibitor was the most effective schedule in mice.

One of these CDK2 inhibitors, kenpaullone, was more effective than four other compounds that are currently in clinical trials for treating hearing loss.

The newly crafted molecule is non-toxic, simple to produce, and cost - effective compared to the production of alternate treatment strategies, such as antibodies and small molecule inhibitors.

Drugs known as PARP inhibitors have already been approved for BRCA - positive ovarian cancer, suggesting that PARP inhibitors may prove effective in prostate cancers with this type of aberration.

«The benefits seen in COMPASS are on the top of other effective therapies such as statins, aspirin, ACE inhibitors and beta blockers, and so their collective impact is substantial.

Studies show that PD - 1 inhibitors are effective for a larger proportion of melanoma patients than ipilimumab alone — and, in combination with that drug, they achieve a two - year survival rate of 80 percent.

Checkpoint inhibitors already produce unprecedented rates of long - term remission for a handful of hard - to - treat cancers, but their potential is even greater: Because such drugs modify the body's response to cancer, rather than the cancer itself, they could theoretically be effective against almost any kind of malignancy.

Marnett, whose university has patented this class of permanent COX - 2 inhibitors, hopes to team up with a pharmaceutical company to come up with an even more effective version of this new superaspirin.

Vemurafenib joins other multi-targeted kinase inhibitors (MKIs)(sorafenib, lenvatinib) shown to be effective in this patient population; in spite of responses to these drugs, the responses are temporary and additional treatment options are needed.

«By helping us understand that lower levels of RNF125 confer resistance to BRAF inhibitors, we have a new strategy to stratify patients for currently approved therapy versus participation for human clinical trials to investigate whether targeting JAK1 will be more effective in patients whose tumors exhibit reduced RNF125,» said Keith T. Flaherty, M.D., associate professor, Harvard Medical School, and director of Developmental Therapeutics, Cancer Center, Massachusetts General Hospital, and co-author of the study.

Recent evidence suggests that inhibitors of PCSK9, a liver enzyme involved in regulating cholesterol homeostasis, could provide an effective alternative or adjunct to statin therapy in high - risk hypercholesterolemic patients.

The findings suggest that targeting newly discovered pathways could be an effective approach to improving the clinical outcome of patients with BRAF inhibitor - resistant melanoma tumors.

«This suggests that PGAM1 inhibitors can sensitize cancers to PARP inhibitors such as Olaparib, thereby expanding the benefits of PARP inhibitors to BRCA1 / 2 - proficient cancers, particularly triple - negative breast cancers that currently lack effective therapies,» says author Min Huang.

Promising preliminary research indicate that at least one of these mTor inhibitors may be effective in halting progression of the disease.

Hence, the combination of ERK1 / 2 and ERK5 inhibitors may lead to more effective treatments for colorectal cancer patients.»

«We found that when apoptosis was impaired, for instance by loss of BIM, the BET inhibitors were no longer effective,» he said.

Researchers at Penn Medicine, in collaboration with a multi-center international team, have shown that a protease inhibitor, simeprevir, a once a day pill, along with interferon and ribavirin has proven as effective in treating chronic Hepatitis C virus infection (HCV) as telaprevir with interferon and ribavirin, the standard of care in developing countries.

Last week, Lin Zhang, MD, an associate professor of Obstetrics and Gynecology, described in Science Translational Medicine, how his team treated therapy resistant cancer cells to renew their sensitivity to PARP inhibitors, a class of drugs that, when effective, prevent cancer cells from keeping up with DNA repair, causing them to eventually die.

Unfortunately, tumors can become resistant to rapalogs after months or years of effective treatment — and it's likely resistance will develop to second - generation mTOR inhibitors, too.

An international research group has now shown that there is another, equally effective oral treatment option: the combination of methotrexate and the chemically synthesised Janus Kinase Inhibitor tofacitinib.

Now, researchers at The Wistar Institute have discovered how STAT3 behaves in immature myeloid cells known as myeloid - derived suppressor cells (MDSCs), and they believe they have found the basis for a much more effective method of using STAT3 inhibitors to stop cancer progression in its tracks.

«Antibody for severe hemophilia a may reduce injections needed to prevent bleeding: First - in - human study of ACE910 suggests excessive bleeding prevention is possible with a weekly subcutaneous injection compared to standard two or three intravenous injections every week, and should be effective in treating patients with inhibitors.»

While this limits the clinical implications of using a 24p3 inhibitor as a sole treatment for leukemia, adding it to a cancer drug such as Gleevec might prove effective, he says.

«But we've found this new class of drugs, checkpoint inhibitors, seems to be more effective than what's been available in the past.»

Poly (ADP - ribose) polymerase (PARP) inhibitors are effective in a broad population of patients with ovarian cancer; however, resistance caused by low enzyme expression of the drug target...

These experiments were essential to understanding the effect of gemcitabine on cell cycle and the effective scheduling of checkpoint inhibitor for maximal malignant cell kill.

«From our present work we hope to one day identify a specific inhibitor of endogenous TORC2 which could also find use as an effective anti-cancer agent,» concludes Taiana Oliveira, a researcher in the group of Christiane Schaffitzel at the European Laboratory of Molecular Biology, in Grenoble, France, and third co-lead author of the study.

To date available data suggest that the combination of BRAF and MEK inhibitors are the most effective treatment strategy [18].

While an earlier study had shown a similar immunotherapy drug to be effective for a significant proportion of patients with advanced melanoma or lung or kidney cancer, checkpoint inhibitors weren't making headway with colon cancer.

«Our results suggest that napabucasin might be an effective STAT3 inhibitor in patients with tumors positive for pSTAT3, and further investigation of napabucasin as monotherapy in advanced colorectal cancer is warranted in these patients,» wrote Derek J. Jonker, MD, of Ottawa Hospital Research Institute at the University of Ottawa, Canada, and colleagues.

«IKKs are one of the most heavily sought after drug targets today, because pharmaceutical companies want safe and effective medications to treat the pain of arthritis, now that the safety of COX - 2 inhibitors, like Celebrex and Vioxx, have been called into question,» says Salk researcher Vinay Tergaonkar who was involved in the zebrafish study.

The discovery builds on research showing that a promising class of new drugs for BRCA2 linked breast cancers — known as PARP inhibitors ** — may also be effective in men who have developed prostate cancer due to a BRCA2 alteration.

Together, our data suggest that clinical studies may be warranted to evaluate the therapeutic potential of ABL allosteric inhibitors and to determine whether combination therapies that incorporate these compounds are effective in treating metastatic breast cancer.

Led by Leena Gandhi, MD, PhD, associate professor of medicine and director of thoracic medical oncology, researchers from the KEYNOTE - 021 study demonstrated for the first time that combining an immune checkpoint inhibitor — in this case, pembrolizumab — with a platinum - doublet chemotherapy regimen might be more effective than chemotherapy alone as first - line treatment for advanced, non-squamous NSCLC.

We also observed inhibition of triple negative breast cancer cells, HCT1143 and MDA - MB231, with RIPK2 inhibitor 1 (Supplemental Fig. 4B), suggesting effective antiproliferative properties.

The Helleday Team proudly presents our new potent MTH1 inhibitor Karonudib, which is 20 times more effective than the previously described TH588 inhibitor, recently published in Annals of Oncology.

They discovered that inhibitors of the protein EZH2 provided an effective strategy for treating ovarian cancers with elevated CARM1 expression.

The DNA methyltransferase inhibitor 5 - azacytidine (AZA) is the most effective pharmacological option, but only ∼ 50 % of patients respond.

A multi-center randomized trial was conducted to determine if acupuncture would be effective in relieving pain as a result of aromatase inhibitors, a commonly used treatment for breast cancers that are hormone sensitive.