Sentences with phrase «effective targeted therapies»

This work may lead to the development of novel and more effective targeted therapies to treat medulloblastoma, and improve the survival and quality of life of affected patients.

This knowledge will improve patient survival by enabling the development of high - performing early detection approaches and more effective targeted therapies.

The Hematologic Malignancies Translational Center of Excellence (TCE) is a multidisciplinary center that seeks to redefine the diagnostic and therapeutic approaches to blood cancers, including leukemia, lymphoma and myeloma, and provide more effective targeted therapies.

Martin Carroll, MD and Edward Stadtmauer, MD are leading efforts at this TCE to redefine the diagnostic and therapeutic approaches to blood cancers — including leukemia, lymphoma and myeloma — and provide more effective targeted therapies.

Penn Medicine's Hematologic Malignancies Translational Center of Excellence seeks to redefine the diagnostic and therapeutic approach to blood cancers in order to provide more effective targeted therapies.

Little is known, however, about the metabolic pathways that drive the growth of individual glioblastoma subtypes — knowledge that is crucial for developing novel and effective targeted therapies that might improve treatment for these lethal tumors.

There are currently no effective targeted therapies to this form of breast cancer, which is therefore often fatal.

TNBC is deadly because, unlike other types of breast cancers such as estrogen receptor (ER) positive or HER2 amplified breast tumours which have effective targeted therapy, TNBC tumours do not respond to targeted therapy.

Not exact matches

With further study, this regulatory network could be a more effective target for epilepsy therapies, including implantable stimulation devices that would help quiet a localized seizure before it spreads throughout the brain.

All are examples of translational researchers converting molecular knowledge about specific cancer cells into effective, targeted therapies.

«The findings also suggest that therapies targeting the immune system may be effective treatments against this disorder and possibly other forms of epilepsy,» said Nath.

Therefore, common treatments such as endocrine therapy and molecular targeting of the HER - 2 receptor are not effective for this breast cancer subtype.

Yet studies have shown single therapies targeting only one part of the immune system have been effective in only a small percentage of patients.

«We found that the protein isoforms expressed in African Americans with prostate cancer do not always respond to targeted therapies, whereas these drugs were found to be effective in European Americans with prostate cancer and do end up killing off the cancer,» said Lee.

«While immune checkpoint blockade therapy is effective in many cancers, it has been less successful for this particular form of prostate cancer, which has motivated a search for targeted therapies that overcome this resistance.»

«It is expected that this study will lay the foundation for developing a new class of potent and effective cancer therapies and the development of reagents targeting epigenetic events in immune - mediated diseases as well as other epigenetically - influenced diseases,» said Alani, who also is chief of dermatology at Boston Medical Center.

«Genes may cause tumor aggressiveness, drug resistance in African - American prostate cancer: Research found many targeted therapies for prostate cancer may not be effective against tumors in African - American men.»

Over the past 2 decades, few effective treatments for this cancer type have been identified, as PanNETs» heterogeneity has complicated the design of targeted therapies.

The researchers believe that effective cancer therapy in the future will require the combined action of drugs that target both the tumor and its adaptive responses to initial therapies.

Researchers have attempted to identify targeted therapies that are effective and do not harm unaffected tissues.

That trend is problematic considering that African - Americans — the most at - risk population for multiple myeloma — have different genetics that can affect how this type of cancer progresses and what kind of targeted therapies are most effective, said Zarko Manojlovic, lead author of the study.

Moreover, her studies are the first to indicate that therapies targeted at controlling the properties of smooth muscle cells within lesions may be highly effective in treating a disease that is the leading cause of death worldwide.

The findings suggest that targeting proteins in the BRAF pathway may open new avenues for treating chronic itch, a condition in which few therapies are effective.

The identification of these opiate - induced changes offers the best hope for developing more effective pharmacological targets and therapies to prevent or reverse the effect of opiate exposure and addiction.

It's the target of very effective anti breast cancer therapy.

«Research into basic workings of immune system points to way of improving therapies for cancer: Differences in wiring of «exhausted» and effective T cells indicate possible gene - editing targets.»

«By helping us understand that lower levels of RNF125 confer resistance to BRAF inhibitors, we have a new strategy to stratify patients for currently approved therapy versus participation for human clinical trials to investigate whether targeting JAK1 will be more effective in patients whose tumors exhibit reduced RNF125,» said Keith T. Flaherty, M.D., associate professor, Harvard Medical School, and director of Developmental Therapeutics, Cancer Center, Massachusetts General Hospital, and co-author of the study.

By tracking and understanding which host cell pathways are manipulated by these T. gondii proteins, scientists can identify potential new targets to develop more effective therapies against highly aggressive solid tumors.

There's a school of thought, Sharma notes, that combining multiple genomically targeted therapies might prove effective.

As the central nervous system is also a target of AAV vectors, Hélène Puccio and Patrick Aubourg's teams are investigating whether a similar approach using gene therapy could be as effective for the spinal cord and cerebellum as it is for the heart.

This webinar is the third in a series focusing on the cancer pathways that support tumor development, the emerging research in identifying and targeting these pathways, and innovations in the development of increasingly effective cancer therapy options.

This webinar is the second in a series (see Part 1 here) focusing on the cancer pathways that support tumor development, the emerging research in identifying and targeting these pathways, and innovations in the development of increasingly effective cancer therapy options.

Study co-author Nigel Bamford, a pediatric neurologist at the University of Washington School of Medicine, says that if similar changes occur in humans, it will indicate that an effective way to fight addiction may be to design therapies that target the affected area — the striatum, a forebrain region that controls movement but also has been linked to habit - forming behavior.

In doing so, they hope to contribute to the development of more effective, precise and target - driven therapies to prevent heart disease in women.

Because the vaccine causes the body to mount an immune response directed against a unique tumor, the therapy is much more effective than gene - targeted or more general chemotherapy alone.

Triple - negative cancers are so called because they do not express receptors for the hormones estrogen and progesterone, nor for HER2 (human epidermal growth factor 2), and hence patients with these cancers are not candidates for treatment with modern hormonal therapies or the highly effective HER2 - targeted drug Herceptin (trastuzumab).

«Our findings may not only help to understand the causes of depression, but also may provide a new biochemical target for developing more effective therapies.»

In the Cancer Cell article, the researchers describe how various anticancer drugs, including cisplatin and the targeted therapy vemurafenib, which targets melanomas with the BRAF mutation, become more effective when co-delivered with phenformin.

«This breakthrough could lead to more effective therapies for women with this very common subtype of breast cancer and be the therapeutic target that the drug companies have been waiting for.»

A highly targeted cancer radiation therapy may offer a safe and effective treatment option for elderly pancreatic cancer patients unable to undergo surgery or combined chemotherapy and radiation therapy, according to researchers at Henry Ford Hospital in Detroit.

However, it is the nature of all molecular targeting therapies that they can only be effective if the target is sufficiently expressed in the tumors.

«At Exeter we are already developing specific psychological therapies, running clinical trials of novel drug approaches and using - cutting edge genetic techniques to identify new targets for safe and effective therapies and to allow us to use current treatments in a more focussed way.»

«Because transcription factors have proven so difficult to block with targeted therapies, we wanted to see if an alternative approach that targets these defective transcriptional mechanisms would be effective.»

The real value of the new research may be that these receptors can provide new and more effective therapies for current addicts, says Michael Nader, a physiologist and pharmacologist at the Wake Forest University School of Medicine in Winston - Salem, N.C. «This identifies a target,» he says.

«Our research adds weight to the idea that effective antifungal drugs can target even those mitochondrial proteins that are highly conserved in humans and fungi, and that this could be a way to make a broad spectrum antifungal combination therapy that would be less susceptible to resistance,» says Benjamin Vincent, a former graduate student in Whitehead Member Susan Lindquist's lab who is now a scientist at Yumanity Therapeutics.

The results from our new study suggest that entinostat may enhance the anti-tumor efficacy of PD - 1 targeted therapy through MDSC targeting, potentially providing an effective combination treatment approach for patients with solid tumors, including lung and renal cell carcinoma.»

Predictive biomarkers of response are becoming increasingly important in the development of effective clinical trials of targeted therapies.»

«Targeting with a humanized MAG - 1 can likely be effective, especially when given in combination with chemotherapy, for treating a deadly disease for which there is no effective therapy.»

The field has experienced monumental challenges developing new and effective drug therapies, not the least of which was the discovery that — until recently - clinical trials were conducted where up to 30 % of participants did not have the Alzheimer's disease - related brain change targeted by the experimental drug.

Therapies based on immune cells, which target particular tumor molecules, are more specific, but they are not effective against a variety of tumors.