Sentences with phrase «effective vaccine response»

Not exact matches

Understanding the body's immune response to a given vaccine could help make better and more effective vaccines in the future.

The results from the study could be used to help public health officials to plan a more effective response to future pandemics, such as rolling out vaccines at a much earlier time and targeting specific types of vaccines at different age groups.

«We are pleased to have demonstrated such a potent and durable immune response to the vaccine,» said the study's lead author, Sita Awasthi, PhD, a research associate professor of Infectious Diseases at Penn. «If found effective in clinical trials, the vaccine will have a huge impact on reducing the overall prevalence of genital herpes infections and could reduce new HIV infections as well, especially in high - burden regions of sub-Saharan Africa.»

Equipped with this deeper understanding, researchers are trying to make allergy vaccines safer and more effective by designing them to micromanage the allergic immune response.

Adjuvants can stretch the amount of vaccine made from a given amount of viral protein and reduce the number of shots needed to trigger an effective immune response.

To develop an effective vaccine, it is imperative to identify a suitable antigen structure of the virus which will create an effective immune response in humans.

«Our new work suggests that vaccines targeting either virus could be engineered to induce both T cell and antibody responses effective to protect people in these areas.»

The vaccine generated a pool of TH1 CD4 + T cells (also called helper T cells) that are necessary for an effective antibody response as well as a stable pool of CD8 + T memory cells.

«Although data clearly indicate better immune responses and vaccine efficacy against both genital warts and cervical dysplasia when vaccination occurs before age 14, this study suggests that HPV vaccination may be effective in reducing abnormal Pap test results even after sexual debut,» explained co-author Rebecca Perkins, MD, MSc, assistant professor of Obstetrics and Gynecology at Boston University School of Medicine and a gynecologist at Boston Medical Center.

«We learned in this study that grabbing hold of these glycans can be a very important early step in an effective immune response to HIV, and with this knowledge, we believe we can design better candidate vaccines,» said principal investigator Dennis R. Burton, professor of immunology and microbiology at TSRI.

Future candidate vaccines are therefore likely to include this glycan cluster among their specific viral targets in order to maximize the chances of stimulating an effective antibody response.

Because the vaccine causes the body to mount an immune response directed against a unique tumor, the therapy is much more effective than gene - targeted or more general chemotherapy alone.

The cholera studies led to the scuttling of a leading vaccine candidate, a finer understanding of effective immune responses, and, ultimately, compelling evidence that a different cholera vaccine worked.

This is why it is so difficult for humans to mount an effective immune response and why it is challenging for researchers to develop vaccines targeting the HIV envelope proteins,» Dr. Blanchard says.

Because the immune system mounts an inadequate protective response against HIV, an HIV vaccine most likely will not be as effective as proven vaccines used to control or end global outbreaks, such as yellow fever and polio vaccines, which are nearly 100 percent effective.

Cancer vaccines, engineered to continue to train T cells to mount a strong immune response against your cancer, also haven't been very effective at mounting a strong fight, says He, and likely one weak point is the lack of strong receptors.

The DNA vaccine for Zika virus is more immunogenic and effective than other vaccines because it can create memory responses, which inactivated vaccines with killed viruses fail to produce, Higgs said.

Despite decades of attempts to develop effective cancer treatment vaccines, they have mostly failed at producing potent antitumor immune responses.

The vaccine, if effective, would be given in two doses, one to prime the immune system to recognize these dangerous invaders, and a booster shot of a different vaccine that would amplify the immune response.

Blocking IL - 15 or IL - 15 signaling may be a way to restore oral tolerance to gluten and allow effective responses to vaccines aimed at preventing development of celiac disease, Jabri said.

Because hemagglutinin also happens to be the part of the flu vaccine that induces an immune response in people (it's the H in a virus name like H5N1), each mutation renders the vaccine less effective.

The primary focus will be to work as a member of the team responsible for delineating the immune response against nairoviruses to aid effective vaccine design.

Since immune responses to vaccines can differ around the world, these findings are encouraging for the development of an effective Ebola vaccine for Africa,» said Merlin Robb, M.D., Director for Clinical Research at the US Military HIV Research Program (MHRP), whose site in Uganda, Makerere University Walter Reed Project (MUWRP), conducted the study.

Through long - established collaborations in Durban and Kimberley, these studies in particular seek to define: the immune responses that are effective in control of HIV infection; the impact of HLA - mediated selection pressure on HIV at the individual and population level; the mechanisms of HIV non-pathogenicity; the nature and consequences of ontogeny of the virus - specific immune response; and finally the prospects for interventions including antiretroviral therapy, alone or in combination with broadly neutralising antibodies and / or T - cell vaccines, to achieve HIV eradication.

Immune Design is a new generation vaccine company built on emerging understanding of the role of dendritic cells in determining an effective immune response.

Earlier vaccinations are not effective because kittens ingest beneficial protective antibodies in their mother's milk during the first few hours after birth, but these antibodies also interfere with their responses to vaccines.

Adjuvants cause the vaccine to be more effective at stimulating an immune response, which is the way that vaccines provide protection from disease.

If there are high levels of these antibodies in your pup's bloodstream, they will reduce his response to the vaccine and it won't be as effective.

Although no one knows for sure at exactly what age this happens, research shows that by 16 weeks combination shots are extremely effective at producing an adequate immune response to the diseases targeted by the AAHA's core vaccines.

Killed vaccines need to be repeated in order to be effective in many cases because they do not continue to stimulate an immune response by viral reproduction like modified live vaccines.