Sentences with word «effector»

In their models, abatacept reduced the proliferation and activation of effector T cells.

Major areas of activity in our lab include 1) identification and characterization of Sgenes, 2) genomic analyses to identify the diversity of TAL effectors in pathogen populations and understand their evolution, and 3) structural and biochemical studies to better harness the unique properties of these proteins for applications such as targeted gene regulation and genome editing.

c - Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function.

In this pathway, dopamine - and an adenosine 3 ′, 5 ′ - monophosphate (cAMP)-- regulated phospho - protein of 32 kilodaltons (DARPP - 32) is phosphorylated or dephosphorylated at three sites, in a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - Fos.

In many cases the damage is caused by a particular group of immune cells called effector memory T - cells.

In order to assess whether previously uncharacterized but highly - induced genes represent novel immune effector molecules, we assessed which and how many of these genes encode proteins that possess properties common to known AMPs.

We are currently investigating the details of the signaling cascades involved in these phenomena, as well as attempting to identify cytoplasmic binding partners for NG2 which may serve as effector molecules for activation of downstream signaling events.

Science magazine heralded these transcription activator - like effector nuclease proteins, known as TALENS, as a major scientific breakthrough in 2012, nicknaming them «genomic cruise missiles» for their ability to allow researchers to target specific locations with great efficiency.

We are supporting research projects with new fast transgenic mouse technology employing TAL effector nucleases — read more in Flemr M, Malik R, Franke V, Nejepinska J, Sedlacek R, Vlahovicek K, Svoboda P: A Retrotransposon - Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes.

Apoptosis has been implicated as a T cell - dependent immune effector mechanism in various forms of organ graft rejection (29 — 31).

The developments and applications of genome editing with custom endonucleases began in 2005 with Zinc - Finger Nucleases (ZFN), followed in 2011 by the TALE - Ns, for «Transcription - Activated like Effector Nucleases».

The immune effector response is sub-optimal because tumors develop multifactorial strategies to escape immune deletion 181, 182.

The attraction of large - scale compound screening for life science researchers lies mainly in the technical challenge of assay design and the use of small - molecule effectors for hypothesis - driven research.

Yersinia pseudotuberculosis and many similar bacteria infect humans by injecting toxins, so - called effector proteins, through a needle - like organelle called injectisome.

TNF is one of the most potent effector cytokines in the pathogenesis of autoimmune disorders, and blockade of TNF with anti-TNF antibodies is an effective treatment for many patients with IBD.

EOS100850 potently rescues Th1 cytokine production in human whole blood treated by A2A agonists, and increased CD8 + T cell cytotoxicity in a co-culture assay of effector CD8 + T cells and target cancer cells

The phenotype of NP cells generated ex vivo (Figure S8) closely resembles that of central memory CD4 + T cells found in vivo, which persist for years in secondary lymphoid organs and can differentiate into effector memory CD4 + T cells [45].

Regulation of endosome dynamics by Rab5 and Huntingtin - HAP40 effector complex in physiological versus pathological conditions.

CRN13 candidate effectors from plant and animal eukaryotic pathogens are DNA - binding proteins which trigger host DNA damage response.

Whereas acute CD8 + T cell effector responses are enhanced in DGKζ - deficient mice postinfection with intracellular pathogens, persistent memory formation is impaired, most dramatically when both DGKζ and DGKα, the other isoform of DGK that metabolizes DAG downstream of the TCR in T cells, are deleted (35, 36).

Additional analysis showed that the vaccine had prompted production of SIV - specific effector memory T cells in protected monkeys.

DKO mice, however, have a decreased percentage of memory precursor cells and an increase in short - lived effector cells compared with WT mice.

Antibodies are key effector molecules in health and disease as they harbor the ability to recognize specific molecular structures and, consequently, elicit immune responses.

[13] Effector sites include areas such as the lamina propria, exocrine gland stroma, and surface epithelia, where mature lymphocytes perform their functions, such as releasing cytokines and secreting antibodies.

Activated heterotrimers have a wide array of effectors including adenylate cyclase (AC), phospholipase C - beta, PI 3 - kinases, GIRK channels and RhoA

JLS Automation of York, Pa., announces the Impulse Multipick series end effectors for high speed picking applications...

«It is likely that rapid evolvement of new bacterial effectors contributed to the resurgence of this disease.»

They systematically deleted genes for secreted effector proteins — molecules that the parasite injects into a host cell to modulate the immune system during infection — and injected the altered parasites into mice with aggressive ovarian cancer.

Current working model of effector activation and feedback mechanisms in type I interferon signaling.

Calmodulin (CaM) is a major effector for the intracellular actions of Ca2 + in nearly all cell types.

The team additionally identified a new effector pathway for alloreactive T cells.

His lab strives to gain a better understanding of the molecular mechanisms that confer stem / progenitor and effector phenotypes onto cells in order to develop more efficacious MSC - based therapies.

Partial activation of the yeast pheromone response pathway by beta - adrenergic receptor agonists was achieved in cells coexpressing h beta - AR and a mammalian G protein (Gs) alpha subunit - demonstrating that these components can couple to each other and to downstream effectors when expressed in yeast.

«Most of the signals that people are working with and identifying right now are the most abundant signals — the main effector proteins,» says Klemke.

Our studies and others have shown that screening of compound libraries for small - molecule effectors offer a powerful method for generating research tools.

One rare KRAS allele, D33E, displayed tumorigenicity and constitutive activation of known RAS effector pathways.

Innate Immunity Together with Duration of Antigen Persistence Regulate Effector T Cell Induction

Developing protocols aimed at inhibiting effector T cells would be key for the treatment of T cell - dependent autoimmune diseases including type 1 autoimmune diabetes (T1D) and multiple sclerosis (MS).

Most well - characterized effector molecules in other insects are secreted into the hemolymph: in our study, 91.2 % of previously identified AMPs have bioinformatic evidence indicating presence of a signal peptide.

299/4: 30 Large - scale exome chip association analysis identifies novel type 2 diabetes susceptibility loci and highlights candidate effector genes.

IFN - γ production is one of the primary effector functions of activated CD8 T cells in response to LCMV infection, and has been shown to be a key component of mortality in the naive mouse model of FHL2 (8).