Sentences with phrase «effector cytokines»

IL - 22 is one of the most biologically important effector cytokines produced by ILC3s.

TNF is one of the most potent effector cytokines in the pathogenesis of autoimmune disorders, and blockade of TNF with anti-TNF antibodies is an effective treatment for many patients with IBD.

However, unlike the BALB / c model, immunization in B6 mice results in a qualitative difference, with prominence of other cytokines in addition to IFN - γ and specifically with TNF - α gaining a pathogenic role as an effector cytokine.

Not exact matches

We will develop mathematical models to predict the pathways of differentiation from naive to memory and effector T - cell subsets based on the characterisation of surface marker expression, transcription factors and cytokines production at early and late time points after immunisation.

Naïve T cells then expand and differentiate into effector T lymphocytes that acquire either cytotoxic activity or secrete high amounts of certain cytokines.

These include examinations of the effect of antigen structure on the spectrum of cytokines produced after either in vivo or in vitro stimulation, as well as the ability to anergize Vα14 iNKT cells in terms of cytokine production and effector function by prior antigen challenge.

We have also have adopted a number of lines of study into the regulation of cytokine production and effector cell responses such, as cytotoxicity, in the response of Vα14 iNKT cells to glycolipid antigens or IL - 12 from activated DCs.

Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function.

Deletion of DGKζ from T cells results in prolonged TCR signal transduction downstream of DAG, resulting in enhanced activation of Ras, increased effector T cell proliferation, and amplified cytokine production, which leads to increased antitumor activity against s.c. implanted EL4 tumors or murine mesothelioma (12, 16, 17).

EOS100850 potently rescues Th1 cytokine production in human whole blood treated by A2A agonists, and increased CD8 + T cell cytotoxicity in a co-culture assay of effector CD8 + T cells and target cancer cells

Initial studies demonstrated that ligation of 4 - 1BB on T cells could deliver costimulatory signals resulting in either increased proliferation or enhanced cytokine secretion and also control clonal expansion and differentiation of effector and memory T cells.

[13] Effector sites include areas such as the lamina propria, exocrine gland stroma, and surface epithelia, where mature lymphocytes perform their functions, such as releasing cytokines and secreting antibodies.

In addition to IL - 22, ILC3s also secrete other effector molecules, including the cytokine GM - CSF.

IL17 is a cytokine with roles in anti-bacterial and anti-fungal defense that is made abundantly by effector T cells at epithelial surfaces (Littman and Rudensky, 2010).