Sentences with phrase «effector functions»

Immune effector functions of CD8 − or CD8 + T cells from C57BL / 6 CD4 KO mice were assessed using delayed - type hypersensitivity assays and Annexin V apoptosis assays respectively.

Topical Resiquimod Can Induce Disease Regression and Enhance T - cell Effector Functions in Cutaneous T - cell Lymphoma

Project Title: Topical Resiquimod Can Induce Disease Regression and Enhance T - cell Effector Functions in Cutaneous T - cell Lymphoma

In addition to Sauer, Eugene Park of Washington University School of Medicine was a co-first author of the study, «Inositol Tetrakisphosphate Limits NK Cell Effector Functions by Controlling Phosphoinositide 3 - Kinase Signaling.»

These results suggest GSK2636771 treatment can «synergize» with OX40 agonist antibodies to augment effector functions of tumor - reactive T cells.»

Dr. Shanker's pioneering studies in murine tumor models identified that tumor - infiltrating CD8T cells provide a necessary «help» to dormant intratumoral natural killer (NK) cells in eliciting their antitumor effector function.

Specificity in Toll - like receptor signalling through distinct effector functions of TRAF3 and TRAF6.

We have shown that invariant Natural Killer T cells (iNKT), a subset of CD1d - restricted T cells displaying innate effector functions, rewire the prostate cancer microenvironment leading to cancer control.

IFN - γ production is one of the primary effector functions of activated CD8 T cells in response to LCMV infection, and has been shown to be a key component of mortality in the naive mouse model of FHL2 (8).

Flow cytometry and high - content analysis experimental data will be presented to demonstrate performance in receptor occupancy, antibody internalization, and effector function assays using antibodies against CD20, CD71, and HER2 in breast cancer and leukemia models.

This demonstrates that aging is associated with a marked accumulation of CMV - specific CD8 T cells together with a decrease in immediate effector function.

c - Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function.

These include examinations of the effect of antigen structure on the spectrum of cytokines produced after either in vivo or in vitro stimulation, as well as the ability to anergize Vα14 iNKT cells in terms of cytokine production and effector function by prior antigen challenge.

Binding of adenosine to the A2A receptor on immune cells blocks the activation and effector functions of anti-tumor immune cells and promotes a regulatory, immune - suppressive phenotype.

Thus, these cells are termed preset T cells, as they also display a variety of effector functions.

Apoptosis of BALB / c corneal endothelial cells was mediated by double negative (DN) T cells, as treatment of CD8 − cells from CD4 KO mice with anti-Thy 1.2 plus complement abolished their effector function.

The Hulse lab is interested in elucidating the mechanisms of B cell activation, effector function, and antibody production at peripheral sites during chronic inflammation, particularly in the airways.

Presentation Title: EOS884448 a novel ADCC - Enabling Antibody Targeting TIGIT Restores T Cell Effector Functions and Displays Anti-Tumor Efficacy Date & Time: Wednesday, February 14, 2018 Authors: Grégory Driessens Poster Number: 35

The adenosine A ₂ ₐ receptor is the main adenosine receptor expressed on immune cell subsets including T - cells, NK cells and dendritic cells and binding of adenosine to the A ₂ ₐ receptor on immune cells blocks the activation and effector functions of anti-tumor immune cells and promotes a regulatory, immune - suppressive phenotype.

EOS884448 a novel ADCC - Enabling Antibody Targeting TIGIT Restores T Cell Effector Functions and Displays Anti-Tumor Efficacy

Novel targets identified for cancer and inflammatory diseases, dying tumour cells release potassium ions to impede T cell effector functions and interferon lambda proves to be an effective anti-viral are covered in our Immunology Update for September.

To reverse the attenuating effects of potassium on T cell effector function, the team genetically engineered tumour - specific T cells to express additional molecular pumps that specifically remove surplus potassium from the cell.