Sentences with phrase «effector genes for»

136/6: 15 Trans - ethnic meta - analysis reveals novel loci and effector genes for kidney function in diverse populations.

Not exact matches

They systematically deleted genes for secreted effector proteins — molecules that the parasite injects into a host cell to modulate the immune system during infection — and injected the altered parasites into mice with aggressive ovarian cancer.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

As the end products and biological effectors of gene expression, proteins are crucial for improving our understanding of human biology, developing new and better drugs, and advancing precision medicine.

As mRNA isolation is simple and since DNA microarrays are a proven genomics reagent for monitoring differential gene expression, a genome - wide expression analysis may be the fastest and most efficient method for identifying additional candidate effectors of colony queen number.

The variety of new tools available for genetic manipulation now include lentiviral - based gene delivery, and gene editing using CRISPR / Cas9, zinc finger nucleases (ZFNs) or transcription activator - like effector nucleases (TALENs).

For the past 20 years, he has identified and characterized several important naturally occurring TAL effectors in the rice pathogen Xanthomonas oryzae for their disease promoting ability, and most recently he has helped harness the disease - causing TAL effectors for targeted gene editiFor the past 20 years, he has identified and characterized several important naturally occurring TAL effectors in the rice pathogen Xanthomonas oryzae for their disease promoting ability, and most recently he has helped harness the disease - causing TAL effectors for targeted gene editifor their disease promoting ability, and most recently he has helped harness the disease - causing TAL effectors for targeted gene editifor targeted gene editing.

Scatterplot (with jitter of overlapping points) showing fold - change for AMPs, other effectors, recognition, signaling, proteases, and non-immune genes.

This correspondence makes it possible to rapidly identify TAL effector targets, to engineer novel TAL effectors with custom assortments of repeats to bind DNA sequences of choice, and even to customize genes for TAL effector activation (or prevent it!).

Major areas of activity in our lab include 1) identification and characterization of Sgenes, 2) genomic analyses to identify the diversity of TAL effectors in pathogen populations and understand their evolution, and 3) structural and biochemical studies to better harness the unique properties of these proteins for applications such as targeted gene regulation and genome editing.

For the candidate gene in the region, RSPO3, we demonstrated expression in key liver - resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells.

For liver transplant - free survival, we identified a genome - wide significant signal and demonstrated expression of the candidate gene RSPO3 in key liver - resident effector cells.

A patent application has been filed and testing is underway on the protein — called HT - TALENs (short for HIV - targeted transcription activator - like effector nucleases)-- which uses a newly developed gene - editing technique to rid the body's cells of the immunodeficiency virus before it has a chance to multiply and possibly develop into AIDS.