Sentences with phrase «effector mechanism»

Apoptosis has been implicated as a T cell - dependent immune effector mechanism in various forms of organ graft rejection (29 — 31).

The elevation in thermoregulatory set - point means that the previous «normal body temperature» is considered hypothermic, and effector mechanisms kick in.

Either of these effector mechanisms might contribute to corneal allograft rejection.

Rejection by CD8 + T cells does not appear to involve either allospecific CTL or DTH effector mechanisms; however, CD8 + T cells are able to induce significant apoptosis of allogeneic corneal endothelial cells.

Our experts in mucosal vaccine delivery have established in vitro and in vivo models to assess the activity of adjuvants and vaccine formulations on innate and adaptive immune cells, as well their capacity to stimulate different effector mechanisms of clearance.

Murine models of inflammatory arthritis have also expanded our understanding of the role of complex, inter-connected complement activation pathways and effector mechanisms.

The mucosal lining of the female genital tract differs from that of the gastrointestinal tract in terms of cellular composition, microflora, and effector mechanisms of innate and adaptive immunity, although it should be noted that the immunologic anatomy and biology of the genital, anal, and lower rectal tract mucosae are less well defined than those of the remainder of the gastrointestinal tract.

We will specifically employ cellular bioassays including the monocyte monolayer assay and antibody - dependent cellular inhibition assay to determine the role of cellular effector mechanisms in anti-PfSEA-1 mediated immunity.

Work on NLRP3, IL - 1beta and metabolism formed part of the renaissance of interest in immunometabolism, which in this context means intracellular metabolic changes occurring in immunity that are governing for immune and inflammatory effector mechanisms.

«These results suggest that 1) chronic ERT [Estrogen Replacement Therapy] likely acts centrally to decrease Tre [temperaure], 2) ERT lowers the Tre at which heat - loss effector mechanisms are initiated, primarily by actions on active cutaneous vasodilation, and 3) addition of exogenous progestins in HRT effectively blocks these effects.»

Not exact matches

TAL effectors are produced in nature by certain bacteria that infect plants and are able to bind to specific sequences in the plant DNA, thereby neutralizing the plant's defense mechanisms.

Current working model of effector activation and feedback mechanisms in type I interferon signaling.

His thesis was entitled «Structural and biochemical studies of Argonaute reveal the slicing mechanism of RISC - RNAi effector complex.»

Identify the mechanisms of autoreactive T effector and T regulatory expansion in man that can be harnessed to maintain or re-instate self - immune tolerance.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

Helicobacter pylori effector protein CagA activates the signal transduction and activator of transcription 3 (STAT3) signaling pathway: a potential mechanism for gastric cancer development.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

Over the past decade, we have used computational and molecular approaches to annotate mi / si / piRNAs, and to elucidate mechanisms of how they are made and how they are sorted into appropriate Argonaute effector complexes.