Sentences with phrase «effector memory»

«If a person suddenly stops taking their HIV treatments, the virus hidden in effector memory T - cells would spring to life and start producing more HIV, and the virus will spread throughout the body within two weeks.

«Previously it was thought that HIV was hiding primarily in central memory T - cells, but our new HIV genetic sequencing test has revealed that the majority of replication - competent virus is actually hiding in effector memory T - cells.

The phenotype of NP cells generated ex vivo (Figure S8) closely resembles that of central memory CD4 + T cells found in vivo, which persist for years in secondary lymphoid organs and can differentiate into effector memory CD4 + T cells [45].

A recent paper in the experimental biology publication The FASEB Journal describes how peptides found in hookworms inhibit the proliferation of effector memory T cells, which, unlike regulatory T cells, can actually trigger inflammation.

In many cases the damage is caused by a particular group of immune cells called effector memory T - cells.

This implies that TCR signal strength is titrated to balance generation of effector responses with sustained memory (43, 44), such that decreased TCR signaling results in poor acute effector memory expansion and enhanced TCR signaling results in diminished establishment of memory.

Additional analysis showed that the vaccine had prompted production of SIV - specific effector memory T cells in protected monkeys.

The most potent of these, known as effector memory T cells, are activated by a group of proteins known as human leukocyte antigens (HLAs) on the surface of endothelial cells lining the donated organ's blood vessels.

Effector memory CD4 + T cells mediate graft - versus - leukemia without inducing graft - versus - host disease.

Furthermore, CMV - specific CTL have a highly polarized membrane phenotype that is typical of effector memory cells (CD28 -LRB--), CD57 (+), CCR7 -LRB--)-RRB-.

Effector memory T - cells are the cells in the body that «remember» previous infections and how to defeat them.

We suspect that this «junk» HIV can act as a decoy and draw attention away from the «real» virus hiding in the effector memory T - cells,» she said.

However, it is this small proportion of virus that hides in the effector memory T - cells and stops the immune system from fully destroying the virus and eliminating it from the body.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.