Sentences with phrase «effector memory cd4»

We explored how aging affects transcriptional dynamics using single - cell RNA sequencing of unstimulated and stimulated naïve and effector memory CD4 (+) T cells from young and old mice from two divergent species.

Effector memory CD4 + T cells mediate graft - versus - leukemia without inducing graft - versus - host disease.

The phenotype of NP cells generated ex vivo (Figure S8) closely resembles that of central memory CD4 + T cells found in vivo, which persist for years in secondary lymphoid organs and can differentiate into effector memory CD4 + T cells [45].

Not exact matches

The spleen showed increased expansion of antigen - experienced effector and memory CD4 + T - cells.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.