Activation of multiple signaling pathways may allow cells to finely tune expression of
effector molecules as well as provide redundancy and resiliency.
Not exact matches
She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of
molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells
as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.
Antibodies are key
effector molecules in health and disease
as they harbor the ability to recognize specific molecular structures and, consequently, elicit immune responses.
We are currently investigating the details of the signaling cascades involved in these phenomena,
as well
as attempting to identify cytoplasmic binding partners for NG2 which may serve
as effector molecules for activation of downstream signaling events.
One of the ways that
effector molecules are secreted is through extracellular vesicles (EVs) such
as exosomes.