Sentences with phrase «effector pathways»

One rare KRAS allele, D33E, displayed tumorigenicity and constitutive activation of known RAS effector pathways.

The findings suggest an alternate indirect effector pathway that requires processing and presentation of the donor H - Y antigen by recipient endothelium and have implications for both transplantation and autoimmune disease.

The team additionally identified a new effector pathway for alloreactive T cells.

Not exact matches

In this pathway, dopamine - and an adenosine 3 ′, 5 ′ - monophosphate (cAMP)-- regulated phospho - protein of 32 kilodaltons (DARPP - 32) is phosphorylated or dephosphorylated at three sites, in a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - Fos.

Partial activation of the yeast pheromone response pathway by beta - adrenergic receptor agonists was achieved in cells coexpressing h beta - AR and a mammalian G protein (Gs) alpha subunit - demonstrating that these components can couple to each other and to downstream effectors when expressed in yeast.

The final component in this long series of signal sequences is the Yorkie effector protein that is the decisive factor at the end of the Hippo signaling pathway and determines the start of reactivation, growth, and division in the stem cells.

These findings suggested that exhausted T cells are a distinct lineage of T cells in and of themselves instead of just being effector or memory T cells restrained by checkpoint pathways.

We will develop mathematical models to predict the pathways of differentiation from naive to memory and effector T - cell subsets based on the characterisation of surface marker expression, transcription factors and cytokines production at early and late time points after immunisation.

This route starts at the Golgi apparatus and shares features with the well - known secretory pathway by relying on the small GTPase RAB6 and its effector ELKS.

Removing one immune effector element only reveals the presence of an ancillary pathway for allograft rejection.

Actually, almost all signalling pathways that affect cell growth and proliferation directly regulate rRNA synthesis, their downstream effectors converging at the Pol I transcription machinery.

Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector - host interactions and promote intracellular survival.

Murine models of inflammatory arthritis have also expanded our understanding of the role of complex, inter-connected complement activation pathways and effector mechanisms.

We are currently identifying the downstream effectors of this CAMKK2 - AMPK kinase pathway including Tau and some key effectors of autophagy.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

The «HIF - 1 signaling pathway» also activates Glycolysis through the activation of different circuits that trigger effector proteins (PDK1, PFKL, ALDOA, etc.) with annotations such as glycolytic process, canonical glycolysis, glucose metabolic process, etc..

The «HIF - 1 signaling pathway» also inhibits Tricarboxylic acid cycle through the inhibition of circuits that trigger the effector protein PDHA1 with diverse GO annotations such as tricarboxylic acid cycle, acetyl - CoA biosynthetic process from pyruvate or carbohydrate metabolic process

Yes ‐ associated protein (YAP) is a transcriptional co ‐ activator and major effector of the Hippo pathway, promoting cell proliferation and stemness.

Activation of multiple signaling pathways may allow cells to finely tune expression of effector molecules as well as provide redundancy and resiliency.

Identifying any Hymenoptera - specific immune pathways or effectors that may exist is also of key importance for understanding the biology of host - pathogen interactions that may be relevant for such challenges as colony collapse disorder [42]--[44].

Elevated levels of the transcriptional regulators TAZ / YAP, key effectors of Hippo pathway signalling, mediate breast cancer cell growth dependence on exogenous glutamine.

The innate immune system is particularly amenable to characterization with expression - based methodology such as RNA - seq, as one of the key biological consequences of pathogenic infections is the rapid induction of several classes of effector proteins, along with up - regulation of a number of other pathway components.

We have shown in frogs (4), flies (7) and worms (11) that the TCF proteins constitute the effectors of the canonical Wnt pathway.

Helicobacter pylori effector protein CagA activates the signal transduction and activator of transcription 3 (STAT3) signaling pathway: a potential mechanism for gastric cancer development.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

Tcf3 and Tcf1 are two key effectors in the pathway, and are essential in this process (Lluis et al., PNAS 2011; Ombrato et al., Cell Cycle 2012; Aulicino et al., Stem Cell Report 2014).

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells