Sentences with phrase «effectors from»

«My part of it was basically to identify what gene was being activated by a particular effector from the bacteria in order to cause disease,» he said.

Not exact matches

The empirical data tell us that neurons are the functional units that carry sensory information from the body into the brain and carry effector information from the brain to the body.

The researchers studied two types of cells called effector T cells, which activate the immune system to defend our body against different pathogens, and regulatory T cells, which help control the immune system and prevent it from attacking healthy parts of its environment.

We suspect that this «junk» HIV can act as a decoy and draw attention away from the «real» virus hiding in the effector memory T - cells,» she said.

However, it is this small proportion of virus that hides in the effector memory T - cells and stops the immune system from fully destroying the virus and eliminating it from the body.

Effector T cells incite GvHD when they become overactive as the patient's immune system starts to rebuild itself from the donor stem cells.

The team found that exhausted T cells acquired an epigenetic profile distinct from effector or memory T cells.

A calibrated robot has a higher absolute positioning accuracy than an uncalibrated one, i.e., the real position of the robot end effector corresponds better to the position calculated from the mathematical model of the robot.

We will develop mathematical models to predict the pathways of differentiation from naive to memory and effector T - cell subsets based on the characterisation of surface marker expression, transcription factors and cytokines production at early and late time points after immunisation.

Spleen cells (3 × 107) from either experimental or control effector lymphocytes were dispensed into 75 - cm2 tissue culture flasks along with 20 ml of boosting medium and 6 × 105 γ - irradiated (3,000 rad) BALB / c spleen cells (erythrocytes lysed).

Assays were performed in triplicate using effector to target cell ratios ranging from 50:1 to 200:1.

The things that we have demonstrated — such as the fact that the vertical nanowires can deliver any biological effector to any cell type in a spatially selected fashion — have drawn interest from many different people, and we have been working with stem cell institutes and others to demonstrate the unique utility of this particular platform.

We have also have adopted a number of lines of study into the regulation of cytokine production and effector cell responses such, as cytotoxicity, in the response of Vα14 iNKT cells to glycolipid antigens or IL - 12 from activated DCs.

Although similar numbers of total splenic gp33 - LCMV — specific T cells were observed between genotypes (Fig. 5B), the distribution of gp33 - LCMV — specific CD8 + T cell effector and memory subsets were altered, such that there was a significantly lower percentage of short - term effector T cells and reciprocal changes in memory precursor cells among gp33 - specifc CD8 + T cells in WT relative to DKO mice (Fig. 5C), with a trend in changes in absolute cell numbers, consistent with temporal data from peripheral blood (Fig. 5A).

Rab5 and its effector FHF contribute to neuronal polarity through dynein - dependent retrieval of somatodendritic proteins from the axon.

Deletion of DGKζ from T cells results in prolonged TCR signal transduction downstream of DAG, resulting in enhanced activation of Ras, increased effector T cell proliferation, and amplified cytokine production, which leads to increased antitumor activity against s.c. implanted EL4 tumors or murine mesothelioma (12, 16, 17).

A Legionella effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria.

These data indicate that enhanced TCR signaling resulting either from deletion of DGKζ or Cbl - b results in skewed effector versus memory development postinfection with LCMV.

The mucosal lining of the female genital tract differs from that of the gastrointestinal tract in terms of cellular composition, microflora, and effector mechanisms of innate and adaptive immunity, although it should be noted that the immunologic anatomy and biology of the genital, anal, and lower rectal tract mucosae are less well defined than those of the remainder of the gastrointestinal tract.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

The «HIF - 1 signaling pathway» also inhibits Tricarboxylic acid cycle through the inhibition of circuits that trigger the effector protein PDHA1 with diverse GO annotations such as tricarboxylic acid cycle, acetyl - CoA biosynthetic process from pyruvate or carbohydrate metabolic process

CRISPR activators and repressors are thought to be reversible once the effector is inactivated / removed from the system.

Review of «Human adipose derived stromal / stem cells (hASCs) protect against STZ - induced hyperglycemia; analysis of hASC - derived paracrine effectors» from Stem Cells by Stuart P. Atkinson.

Zinc finger nucleases [1], [2], transcription activator - like effector nucleases [3], [4] and homing meganucleases [5] have provided powerful tools to induce targeted mutations in the form of small insertions or deletions derived from DNA break repair of nonhomologous end joining (NHEJ) or homologous recombination.

This response is called effector - triggered immunity, or ETI, and ultimately results in the plant killing off its own affected cells to prevent the bacteria from replicating and spreading.

To reverse the attenuating effects of potassium on T cell effector function, the team genetically engineered tumour - specific T cells to express additional molecular pumps that specifically remove surplus potassium from the cell.

We explored how aging affects transcriptional dynamics using single - cell RNA sequencing of unstimulated and stimulated naïve and effector memory CD4 (+) T cells from young and old mice from two divergent species.

Motor Neuron a type of nerve cell that conveys impulses from the central nervous system to a muscle or other effector tissue.