Sentences with phrase «effects in human cells»

Frederick vom Saal, a reproductive toxicologist at the University of Missouri - Columbia, countered by claiming: «There is essentially no difference in the way that rat or mouse cells respond to BPA and the way that humans respond to it,» adding that while the amount in humans «may seem like an incredibly small amount, it causes effects in human cells at the part - per - trillion level.»

Digenome - seq: genome - wide profiling of CRISPR - Cas9 off - target effects in human cells.

The IBS research team (Center for Genome Engineering) has successfully confirmed that CRISPR - Cas9 has accurate on - target effects in human cells, through joint research with the Seoul National University College of Medicine and ToolGen, Inc..

This hope does not appear to be completely unfounded: The scientists have already discovered a Ret / GDNF effect in human cells with a PINK1 defect similar to that observed in the fruit fly.

Not exact matches

And if you don't deny it, then why discredit the fact that food, the very substance that all humans need in order to keep organs functioning, blood pumping, toxins dispelling, cells forming, could be causing severe effects on our health if the wrong foods are eaten?

Their first visit was to CytoCybernetics, where CEO Glenna Bett explained how her company has developed a system that uses computers and live human cells to screen drugs in their early stages of development, to determine whether they may cause any potentially deadly side effects.

To create the effect of tobacco smoke on cells, Vaz, Baylin and their colleagues began their studies with human bronchial cells, which line the airways of the lungs, and grew them in a laboratory.

Scientists are forced either to experiment on whole animals, which is expensive, raises ethical issues and may not predict effects in humans, or to perform tests on microscopic human cells found in tissue cultures, which have been altered to live forever and bear little relation to actual living, breathing people.

Telomeres naturally shorten as cells divide, and shortened telomeres are associated in humans with the effects of ageing.

«Human stem cells treat spinal cord injury side effects in mice.»

However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials.

Brazilian researchers from the D'Or Institute for Research and Education (IDOR) and Federal University of Rio de Janeiro (UFRJ) have demonstrated the harmful effects of ZIKA virus (ZIKV) in human neural stem cells, neurospheres and brain organoids.

A chemical produced in the pancreas that prevented and even reversed Type 1 diabetes in mice had the same effect on human beta cells transplanted into mice, new research has found.

Ozanne says that similar ageing effects have been identified in beta cells from people with type 2 diabetes, but she adds that her team have yet to prove this is linked to poor maternal diet in humans.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

Similar to the naturally occurring effects of TET2 mutations in mice or humans, using molecular biology techniques to turn off TET2 in mice caused abnormal stem cell behavior.

In preliminary safety tests, the researchers found no harmful effects in four types of human cells, or in ratIn preliminary safety tests, the researchers found no harmful effects in four types of human cells, or in ratin four types of human cells, or in ratin rats.

First, the destabilizing effects of VX - 770 on the corrected CFTR protein might be less robust in the human body than were the effects seen in lab tests using human lung cells.

With a view to clinical studies (tests on humans) it is important to note that the effects on the tumor vasculature were even observed at chloroquine concentrations that had little effect on autophagy in the cancer cells.

In an accompanying paper, MacKinnon's team notes that scorpion toxin — a potent potassium channel inhibitor — has the same effect on pores in S. lividans and those of the fruit fly Drosophila, whose nuclei are organized similar to those of human cellIn an accompanying paper, MacKinnon's team notes that scorpion toxin — a potent potassium channel inhibitor — has the same effect on pores in S. lividans and those of the fruit fly Drosophila, whose nuclei are organized similar to those of human cellin S. lividans and those of the fruit fly Drosophila, whose nuclei are organized similar to those of human cells.

Through these effects, the PERY peptide reduced the proliferation of several (but not all) cancer cell lines in culture and inhibited the growth of a human breast cancer xenograft in mice.

They then examined genetic variants throughout the human genome for their effects on gene expression in these two representative populations of immune cells.

In the lab, the antibiotics had no harmful effect on normal cells, and since they are already approved for use in humans, trials of new treatments should be simpler than with new drugs — saving time and moneIn the lab, the antibiotics had no harmful effect on normal cells, and since they are already approved for use in humans, trials of new treatments should be simpler than with new drugs — saving time and monein humans, trials of new treatments should be simpler than with new drugs — saving time and money.

TOKYO — Research involving human embryonic stem (ES) cells will become easier in Japan as a result of new ethical review requirements that take effect today.

In lab experiments, the researchers isolated exosomes from specialized human cardiac stem cells and found that exosomes alone had the same beneficial effects as stem cells.

By now, European astronauts had hoped to be established in their space laboratory called Columbus, where they would be melting and solidifying conductive metals, studying microgravity effects on single - celled organisms, investigating human balance disorders, and carrying out dozens of other experiments.

To see if PGD and the pentose phosphate pathway were tied to the epigenetic changes the researchers had detected in distant metastases, they treated tumor cells from different sites in a single patient with the drug 6 - aminonicotinamide (6AN), which is known to inhibit PGD but is not used in humans because of its severe side effects.

Investigators at the Cedars - Sinai Heart Institute — whose previous research showed that cardiac stem cell therapy reduces scarring and regenerates healthy tissue after a heart attack in humans — have identified components of those stem cells responsible for the beneficial effects.

Gertsch has himself investigated the effects of BIA 10 - 2474 in human blood cells; that study has yet to be published.

In this study, the researchers tested the effects of Olaparib on the tumors formed by human breast cancer cells injected into mice.

Next, the researchers tested the effects of RK - 33 and radiation in mice that had been injected with human prostate cancer cells that highly express DDX3.

Sood and his team first studied the effects of stress hormones on human ovarian cancer cell anoikis in culture.

«Natural resistance to malaria linked to variation in human red blood cell receptors: First study to identify protective effect of glycophorin gene rearrangements on malaria.»

The Simon lab is now working on testing the effects of the chimera on human liver cells and in mouse livers, to further elucidate its role in the disease.

Cell - based biosensors can simulate the effect of various substances, such as drugs, on the human body in the laboratory.

The investigators studied application of various doses of a common PBDE flame retardant on human adrenal cells in culture dishes and compared the effects with those of only the vehicle, the inactive substance used to deliver the chemical.

And while we successfully demonstrated that cardiolipin can improve the function of mitochondria in flies, mouse models and in human cells, we need to explore its effects in actual patients.»

«The introduction of mitochondria into damaged cells has beneficial effects on the health of cells and, in the long term, we believe that mesenchymal stem cells could even be engineered to create more effective therapies for lung disease in humans.»

Since the thyroid absorbs nearly all of the iodine in the human body, radioactive iodine given to a patient will concentrate in thyroid cancer cells, killing them with little effect on the rest of the body.

This study, which will be published Oct. 24 in eLife, and two other new Northwestern studies in Oncotarget and Cell Cycle by the Peter group, describe the discovery of the assassin molecules present in multiple human genes and their powerful effect on cancer in mice.

In her most recent paper, Ennis describes how her team looked at the effects of ultra-dilute solutions of histamine on human white blood cells involved in inflammatioIn her most recent paper, Ennis describes how her team looked at the effects of ultra-dilute solutions of histamine on human white blood cells involved in inflammatioin inflammation.

This adds the possibility of in vivo experiments on therapeutic effects using human - derived cells in the mouse embryo.

To see what power nucleostemin wields, the researchers looked at its effects in both rat stem cells and human cancer cells.

It is a continuation of previous research, published in 2011, that focused on the effect of decitabine on glioblastoma human cell cultures.

Research involving human embryonic stem cells will become easier in Japan as a result of new ethical review requirements that took effect 21 August.

Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or hematopoietic stem cell transplants.

«We had some indication that rapamycin would enhance the cytotoxic T cell effect, from previous experiments in both animals and humans showing that the drug produced modest effects by itself,» says Maria Castro, Ph.D., senior author of the new paper.

In the first published results from a clinical trial using human embryonic stem cells, two legally blind patients who received an injection of hESC - derived cells in one eye have experienced no harmful side effects and appear to have slightly better visioIn the first published results from a clinical trial using human embryonic stem cells, two legally blind patients who received an injection of hESC - derived cells in one eye have experienced no harmful side effects and appear to have slightly better visioin one eye have experienced no harmful side effects and appear to have slightly better vision.

They show that highly purified NS1 acts as a pathogen - associated molecular pattern (PAMP) that activates mouse macrophages and human peripheral blood mononuclear cells (PBMCs) in culture via TLR4, resulting in release of inflammatory cytokines — an effect that was blocked by either a TLR4 antagonist or an anti-TLR4 antibody.

To determine whether the reactivation of methylation - silenced genes by EGCG is a general phenomenon that also occurs in other cell lines, we studied the effects of EGCG treatment on the methylation status and mRNA levels of p16INK4a or RARβ in three other human cancer cell lines (Fig. 3C) ⇓.