Sentences with phrase «effects of ablation»

This little - heralded, meticulous investigation into the effects of ablation of the telomerase catalytic subunit in mice with human - like telomeres provides us with strong reassurance that, should it prove to be the preferred approach for implementing the OncoSENS strategy, the effects of knocking out TERT would be limited to those dictated by the loss of telomere - lengthening per se, and would not lead to an unintentional loss of some essential but hitherto - unknown phsyiological function.

On the other hand, there are many other tissues — notably, the kidney and articular cartilage — where p16Ink4a - expressing senescent cells appear to be a contributing factor to human and murine degenerative aging, but which were not evaluated in treated or control mice in this study, and it would be of interest to see the effects of ablation of p16Ink4a - positive senescent cells.

Not exact matches

«Our study suggests that in patients with heart failure and atrial fibrillation, catheter ablation is an effective alternative treatment that can help patients avoid or discontinue this drug to reduce the risk of these long - term side effects.»

In effect, this UAV survey across the ablation zone of the ice sheet perfectly bridges the gap between people on the ground studying what's under their feet in just one part of the ice sheet, and the satellite data that shows what's going on across the entire ice sheet.

Ablation of kappa - opioid receptors from brain dopamine neurons has anxiolytic - like effects and enhances cocaine - induced plasticity.

Emory neuropsychologist Dan Drane, who probes the effects of epilepsy surgery on memory and language abilities, had identified Olds as a good example of how the more precise stereotactic laser ablation procedure pioneered by Gross can preserve those cognitive functions, in contrast to an open resection.

To impute aging phenotypes directly to p16Ink4a - expressing senescent cells, van Deursen and colleagues with expertise in the aging and senescence of the relevant tissues developed and tested the effects of a pharmacologically - inducible system for the ablation of p16Ink4a - expressing cells.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

(6) Following this initial test of abrogating the early, age - related rise in p16Ink4a - expressing cell burden, the investigators probed the effects of leaving BubR1H / H; INK - ATTAC to undergo 5 months of rapid «premature aging» (and thus, to the attendant accumulation of high levels of p16Ink4a - positive cells and onset of «early - aging» phenotypes), and only then inducing ablation of senescent cells with the INK - ATTAC drug - activated system (see Figure 2 (g) below).

Whole - body Induced Cell Turnover (WICT) consists of the qualitative and quantitative coordination of targeted cell ablation with exogenous cell administration so as to effect the replacement of a patient's entire set of endogenous cells with exogenous cells (of the same quantity and cell type as the ablated endogenous cells they are replacing) derived from human pluripotent stem cells and directionally differentiated in vitro prior to their administration.

For confirmation, we exploited the flexibility of our system, enabling tamoxifen inducible conditional gene ablation while controlling for genetic background and tamoxifen effects.

Specifically, the metabolic effects of musculoskeletal loading in the current experiments resemble the partial restoration of insulin sensitivity reported in leptin - deficient mice following myostatin ablation (55, 56).

In this estimate, only 4.2 mm per month of liquid water equivalent are due to the mass added by enhanced precipitation; the vast majority of the effect (72 mm per month of decreased ablation) is due to the effect of precipitation on reflectivity.

Detailed studies of the energy balance and ablation of the Zongo and Chacaltaya glaciers support the importance of air temperature increase, and identify the increase in downward infrared radiation as the main way that the effect of the warmer air is communicated to the glacier surface [Wagnon et al. 1999; Francou et al, 2003].

As the authors point out, even if the whole story comes down to precipitation changes which favor ablation, the persistence of these conditions throughout the 20th century still might be an indirect effect of global warming, via the remote effect of sea surface temperature on atmospheric circulation.

This underscores the fact that ablation (via the reflectivity effect) depends on the seasonal distribution of snowfall.

Concerning this effect, one should note that the measured ablation differed by a factor of two between the two years studied, even though annual mean snowfall was similar in both years.

Ludicrous as it may sound to you, a rigorous system model of the effect upon surface temperatures from albedo changes due to snow / ice ablation will not have any feedback loop whatsoever back to the fundamental input of insolation.

The warming could, under certain circumstances, increase the sublimation, but the effect of this on ablation is generally small, because of the high energy required for sublimation.