Sentences with phrase «effects of adverse events»

Older people experiencing typical life stresses are less affected (as measured by number of medical visits) when they have a companion dog, suggesting that a dog can be a stress buffer that softens effects of adverse events on the person.

Another advantage of social networks is their ability to buffer the effects of adverse events.

Not exact matches

The deal has a clause that says Verizon can withdraw if a new event «reasonably can be expected to have a material adverse effect on the business, assets, properties, results of operation or financial condition of the business.»

These risks and uncertainties include competition and other economic conditions including fragmentation of the media landscape and competition from other media alternatives; changes in advertising demand, circulation levels and audience shares; the Company's ability to develop and grow its online businesses; the Company's reliance on revenue from printing and distributing third - party publications; changes in newsprint prices; macroeconomic trends and conditions; the Company's ability to adapt to technological changes; the Company's ability to realize benefits or synergies from acquisitions or divestitures or to operate its businesses effectively following acquisitions or divestitures; the Company's success in implementing expense mitigation efforts; the Company's reliance on third - party vendors for various services; adverse results from litigation, governmental investigations or tax - related proceedings or audits; the Company's ability to attract and retain employees; the Company's ability to satisfy pension and other postretirement employee benefit obligations; changes in accounting standards; the effect of labor strikes, lockouts and labor negotiations; regulatory and judicial rulings; the Company's indebtedness and ability to comply with debt covenants applicable to its debt facilities; the Company's ability to satisfy future capital and liquidity requirements; the Company's ability to access the credit and capital markets at the times and in the amounts needed and on acceptable terms; and other events beyond the Company's control that may result in unexpected adverse operating results.

For example, the expected timing and likelihood of completion of the proposed merger, including the timing, receipt and terms and conditions of any required governmental and regulatory approvals of the proposed merger that could reduce anticipated benefits or cause the parties to abandon the transaction, the ability to successfully integrate the businesses, the occurrence of any event, change or other circumstances that could give rise to the termination of the merger agreement, the possibility that Kraft shareholders may not approve the merger agreement, the risk that the parties may not be able to satisfy the conditions to the proposed transaction in a timely manner or at all, risks related to disruption of management time from ongoing business operations due to the proposed transaction, the risk that any announcements relating to the proposed transaction could have adverse effects on the market price of Kraft's common stock, and the risk that the proposed transaction and its announcement could have an adverse effect on the ability of Kraft and Heinz to retain customers and retain and hire key personnel and maintain relationships with their suppliers and customers and on their operating results and businesses generally, problems may arise in successfully integrating the businesses of the companies, which may result in the combined company not operating as effectively and efficiently as expected, the combined company may be unable to achieve cost - cutting synergies or it may take longer than expected to achieve those synergies, and other factors.

As a result, political instability, labor strikes, natural disasters or other events resulting in the disruption of trade or transportation from other countries or the imposition of additional regulations relating to duties upon imports could cause significant delays or interruptions in the supply of our merchandise or increase our costs, either of which could have an adverse effect on our business.

As part of its mission, the Oneida County Public Health Emergency Response and Preparedness Program (PHERP) assist the community before, during and after an emergency event to prevent or minimize its adverse effects on the health and safety of the residents in the community.

Taking into account the disastrous effects of the 2003 and 2010 heat wave events in Europe, and those of 2011 and 2012 in the USA, results show that we may be facing a serious risk of adverse impacts over larger and densely populated areas if mitigation strategies for reducing global warming are not implemented.

In certain patient groups or aspects of side effects (serious adverse events and treatment discontinuation), however, the data were robust and therefore conclusions could be drawn.

Professor Marco Metra, director of the Institute of Cardiology at the University and Civil Hospital of Brescia, Italy and co-principal investigator of RELAX - AHF, said: «We have reported that all of these adverse effects of a worsening heart failure event are related to increased overall mortality and that a worsening heart failure event itself is related to a two-fold increased risk of dying in 180 days.»

This study should inform those who restrict their view of causes for adverse effects to only postnatal environments and events.

Regarding the robustness of the data, however, there were exceptions in certain patient groups or aspects of side effects (serious adverse events and treatment discontinuation).

The results showed some increased risk for nonserious adverse effects in the medical cannabis group but no difference in the risk of serious adverse events.

In the category «side effects,» significant effects were shown in favour of brivaracetam (for serious adverse events and some specific adverse events, such as dizziness or eye disorders).

As a result, the adverse events, side effects and complications of Neovasculgen were not recorded.

«The side effects were quite high with the combination, with about 30 % of patients discontinuing due to treatment - related adverse events, as compared to 5 % with nivolumab and 13 % for ipilimumab.»

For estimating the causal effect of treatment exposure on the occurrence of adverse events, inverse probability weights (IPW) can be used in marginal structural models to correct for time - dependent confounding.

Label the FDA approved label is the official description of a drug product which includes indication (what the drug is used for); who should take it; adverse events (side effects); instructions for uses in pregnancy, children, and other populations; and safety information for the patient.

The limited reports of complications arising from use of the modified Atkins diet (MAD) or low glycaemic index treatment suggest fewer and less serious adverse events when these more liberal modified diets are used (32, 33, 34, 35), although a prospective review of 6 MAD studies found 13 % of 92 children and adults discontinued the diet due to intolerance or side effects (36).

RECENT STUDY ON ADVERSE EFFECTS OF LOW SODIUM INTAKE About the same time that U.S. health officials announced their new initiative to reduce salt intake, The Lancet published a large population - based study which showed persuasively that the risk of mortality and serious cardiovascular events increases significantly when salt intake drops below 3000 mg per day (two - thirds teaspoon) in an adult of average weight.3 The study also found that sodium intake in excess of seven grams per day (over three teaspoons salt) was associated with an increased risk in those with hypertension, but not in those without hypertensioOF LOW SODIUM INTAKE About the same time that U.S. health officials announced their new initiative to reduce salt intake, The Lancet published a large population - based study which showed persuasively that the risk of mortality and serious cardiovascular events increases significantly when salt intake drops below 3000 mg per day (two - thirds teaspoon) in an adult of average weight.3 The study also found that sodium intake in excess of seven grams per day (over three teaspoons salt) was associated with an increased risk in those with hypertension, but not in those without hypertensioof mortality and serious cardiovascular events increases significantly when salt intake drops below 3000 mg per day (two - thirds teaspoon) in an adult of average weight.3 The study also found that sodium intake in excess of seven grams per day (over three teaspoons salt) was associated with an increased risk in those with hypertension, but not in those without hypertensioof average weight.3 The study also found that sodium intake in excess of seven grams per day (over three teaspoons salt) was associated with an increased risk in those with hypertension, but not in those without hypertensioof seven grams per day (over three teaspoons salt) was associated with an increased risk in those with hypertension, but not in those without hypertension.

Adverse Event Reactions may include any reports of serious side effects, hospitalization and deaths of individuals who have consumed a certain nutrition product.

Because of the unique ability of Anabolic Steroids to boost muscle mass, it's used in professional, non-competitive, or competitive sports events are considered illegal due to the possibility of serious adverse effect which can also lead to a high potential of abuse.

History of safe traditional use No case reports of significant adverse events with high probability of causality No significant adverse events in clinical trials No identified concerns for use during pregnancy or lactation No innately toxic constituents Toxicity associated with excessive use is not a basis for exclusion from this class Minor or self - limiting side effects are not bases for exclusion from this class»

Such statements reflect the current views of Barnes & Noble with respect to future events, the outcome of which is subject to certain risks, including, among others, the general economic environment and consumer spending patterns, decreased consumer demand for Barnes & Noble's products, low growth or declining sales and net income due to various factors, possible disruptions in Barnes & Noble's computer systems, telephone systems or supply chain, possible risks associated with data privacy, information security and intellectual property, possible work stoppages or increases in labor costs, possible increases in shipping rates or interruptions in shipping service, effects of competition, possible risks that inventory in channels of distribution may be larger than able to be sold, possible risks associated with changes in the strategic direction of the device business, including possible reduction in sales of content, accessories and other merchandise and other adverse financial impacts, possible risk that component parts will be rendered obsolete or otherwise not be able to be effectively utilized in devices to be sold, possible risk that financial and operational forecasts and projections are not achieved, possible risk that returns from consumers or channels of distribution may be greater than estimated, the risk that digital sales growth is less than expectations and the risk that it does not exceed the rate of investment spend, higher - than - anticipated store closing or relocation costs, higher interest rates, the performance of Barnes & Noble's online, digital and other initiatives, the success of Barnes & Noble's strategic investments, unanticipated increases in merchandise, component or occupancy costs, unanticipated adverse litigation results or effects, product and component shortages, the potential adverse impact on the Company's businesses resulting from the Company's prior reviews of strategic alternatives and the potential separation of the Company's businesses, the risk that the transactions with Microsoft and Pearson do not achieve the expected benefits for the parties or impose costs on the Company in excess of what the Company anticipates, including the risk that NOOK Media's applications are not commercially successful or that the expected distribution of those applications is not achieved, risks associated with the international expansion contemplated by the relationship with Microsoft, including that it is not successful or is delayed, the risk that NOOK Media is not able to perform its obligations under the Microsoft and Pearson commercial agreements and the consequences thereof, risks associated with the restatement contained in, the delayed filing of, and the material weakness in internal controls described in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, risks associated with the SEC investigation disclosed in the quarterly report on Form 10 - Q for the fiscal quarter ended October 26, 2013, risks associated with the ongoing efforts to rationalize the NOOK business and the expected costs and benefits of such efforts and associated risks and other factors which may be outside of Barnes & Noble's control, including those factors discussed in detail in Item 1A, «Risk Factors,» in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, and in Barnes & Noble's other filings made hereafter from time to time with the SEC.

Such statements reflect the current views of Barnes & Noble with respect to future events, the outcome of which is subject to certain risks, including, among others, the effect of the proposed separation of NOOK Media, the general economic environment and consumer spending patterns, decreased consumer demand for Barnes & Noble's products, low growth or declining sales and net income due to various factors, possible disruptions in Barnes & Noble's computer systems, telephone systems or supply chain, possible risks associated with data privacy, information security and intellectual property, possible work stoppages or increases in labor costs, possible increases in shipping rates or interruptions in shipping service, effects of competition, possible risks that inventory in channels of distribution may be larger than able to be sold, possible risks associated with changes in the strategic direction of the device business, including possible reduction in sales of content, accessories and other merchandise and other adverse financial impacts, possible risk that component parts will be rendered obsolete or otherwise not be able to be effectively utilized in devices to be sold, possible risk that financial and operational forecasts and projections are not achieved, possible risk that returns from consumers or channels of distribution may be greater than estimated, the risk that digital sales growth is less than expectations and the risk that it does not exceed the rate of investment spend, higher - than - anticipated store closing or relocation costs, higher interest rates, the performance of Barnes & Noble's online, digital and other initiatives, the success of Barnes & Noble's strategic investments, unanticipated increases in merchandise, component or occupancy costs, unanticipated adverse litigation results or effects, product and component shortages, risks associated with the commercial agreement with Samsung, the potential adverse impact on the Company's businesses resulting from the Company's prior reviews of strategic alternatives and the potential separation of the Company's businesses (including with respect to the timing of the completion thereof), the risk that the transactions with Pearson and Samsung do not achieve the expected benefits for the parties or impose costs on the Company in excess of what the Company anticipates, including the risk that NOOK Media's applications are not commercially successful or that the expected distribution of those applications is not achieved, risks associated with the international expansion previously undertaken, including any risks associated with a reduction of international operations following termination of the Microsoft commercial agreement, the risk that NOOK Media is not able to perform its obligations under the Pearson and Samsung commercial agreements and the consequences thereof, the risks associated with the termination of Microsoft commercial agreement, including potential customer losses, risks associated with the restatement contained in, the delayed filing of, and the material weakness in internal controls described in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, risks associated with the SEC investigation disclosed in the quarterly report on Form 10 - Q for the fiscal quarter ended October 26, 2013, risks associated with the ongoing efforts to rationalize the NOOK business and the expected costs and benefits of such efforts and associated risks and other factors which may be outside of Barnes & Noble's control, including those factors discussed in detail in Item 1A, «Risk Factors,» in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended May 3, 2014, and in Barnes & Noble's other filings made hereafter from time to time with the SEC.

Such statements reflect the current views of Barnes & Noble with respect to future events, the outcome of which is subject to certain risks, including, among others, the general economic environment and consumer spending patterns, decreased consumer demand for Barnes & Noble's products, low growth or declining sales and net income due to various factors, including store closings, higher - than - anticipated or increasing costs, including with respect to store closings, relocation, occupancy (including in connection with lease renewals) and labor costs, the effects of competition, the risk of insufficient access to financing to implement future business initiatives, risks associated with data privacy and information security, risks associated with Barnes & Noble's supply chain, including possible delays and disruptions and increases in shipping rates, various risks associated with the digital business, including the possible loss of customers, declines in digital content sales, risks and costs associated with ongoing efforts to rationalize the digital business and the digital business not being able to perform its obligations under the Samsung commercial agreement and the consequences thereof, the risk that financial and operational forecasts and projections are not achieved, the performance of Barnes & Noble's initiatives including but not limited to its new store concept and e-commerce initiatives, unanticipated adverse litigation results or effects, potential infringement of Barnes & Noble's intellectual property by third parties or by Barnes & Noble of the intellectual property of third parties, and other factors, including those factors discussed in detail in Item 1A, «Risk Factors,» in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 30, 2016, and in Barnes & Noble's other filings made hereafter from time to time with the SEC.

In the event of a determination adverse to VaxGen, we may incur substantial monetary liability that could have a material adverse effect on the Company's financial position, results of operations or cash flows.

It is clear that veterinarians are not adequately trained to recognise vaccine reactions, and that although the cause and effect is fairly clear if one understands the potential adverse effects of vaccines, the adverse event reporting schemes don't pick up most of these cases.

Adverse drug events are undesired side effects associated with a drug or a lack of effect (the drug doesn't do what it's supposed to do).

* Approximately 70 % of possible adverse drug events have been in older dogs (many of these older pets have preexisting disease, underlying milk dehydration, or are taking multiple medications that predispose to renal or gastrointestinal side effects.)

According to dvm360, the EPA also requested more labeling information about possible adverse effects, as well as instructions to pet owners to consult a veterinarian or the product manufacturer in case of an adverse event.

Now, certainly whether these effects will occur is uncertain, but the proper way to deal with this in risk mitigation is to scale effort by the potential cost of the adverse event multiplied by its probability.

At least two municipal governments reassured investors that they were «unable to predict whether sea - level rise or other impacts of climate change or flooding from a major storm will occur, when they may occur, and if any such events occur, whether they will have a material adverse effect...»» (emphasis added)

As discussed earlier, Hurricane Katrina demonstrated that communities of color, poor communities, and certain other vulnerable populations (like new immigrant communities) are at a higher risk to the adverse effects of extreme weather events.263, 264,239 These vulnerable populations could benefit from urban planning policies that ensure that new buildings, including homes, are constructed to resist extreme weather events.303

A 2017 disclosure by San Francisco reads: «The city is unable to predict whether sea level rise or other impacts of climate change or flooding from a major storm will occur, when they may occur, and if any such events occur, whether they will have a material adverse effect on the business operations or financial condition of the city and the local economy.»

Even with warming of 2 °C, we can expect to see adverse effects on water availability in critical river basins, a more than doubling of forest fires in Amazonia by 2050, impacted coral reef recovery from bleaching events, among other effects.

Climate impact concerns include environmental quality (e.g., more ozone, water - logging or salinisation), linkage systems (e.g., threats to water and power supplies), societal infrastructures (e.g., changed energy / water / health requirements, disruptive severe weather events, reductions in resources for other social needs and maintaining sustainable livelihoods, environmental migration (Box 7.2), placing blame for adverse effects, changes in local ecologies that undermine a sense of place), physical infrastructures (e.g., flooding, storm damage, changes in the rate of deterioration of materials, changed requirements for water or energy supply), and economic infrastructures and comparative advantages (e.g., costs and / or risks increased, markets or competitors affected).

Cardiologists and Risk Managers will be reporting any emergent situations, health issues or side effects that relate to the malfunction of the component sin the Arstasis One Access System to the FDA's MedWatch Safety Information and Adverse Event Reporting Program.

Despite the fact that these side effects have been known since at least 2010, warning labels weren't updated until 2016, following a tidal wave of adverse event reports cited by the FDA.

Facilitates Root Cause and Failure Mode Effect Analysis by working collaboratively with the multidisciplinary team to address systematic process issues as a result of potential and / or actual hospital adverse events

A diagnosis of psychological maltreatment is facilitated when a documented event or series of events has had a significant adverse effect on the child's psychological functioning.

The extent to which stressful events have lasting adverse effects is determined in part by the individual's biological response (mediated by both genetic predispositions and the availability of supportive relationships that help moderate the stress response), and in part by the duration, intensity, timing, and context of the stressful experience.

In comparing competent children with less competent children from highly stressed families, researchers found that a history of early attachment - related competence proved to be a major protective factor against the adverse effects of stressful life events.

Adverse Childhood Experiences (ACEs): Are potentially traumatic events that can have negative, lasting effects on health and well - being; These experiences range from physical, emotional, or sexual abuse to parental divorce or the incarceration of a parent or guardian.

This section examines the effect of adverse family events from pre-school age onwards, additional child characteristics related to physical and mental health, and aspects of parenting and family climate.

Unlike the model of poor father - child relationship, there were no independent effects of parental marital status, presence of a non-biological father figure or adverse family events on the likelihood of a poor mother - child relationship.

«Modeling risks: effects of area deprivation, family socio - economic disadvantage and adverse life events on young children's psychopathology.»

The mechanism by which adverse life events may affect ODD is still unclear, and may vary between types of event; potential explanations include (a) negative effects on maturation of cerebral brain structures in the child due to stress, (b) teaching individuals to use antisocial strategies to cope with stressful situations, and (c) causing an overactive sympathetic nervous system [7, 29].

In terms of the effect on credit history, a deed in lieu of foreclosure or a short sale are not as adverse an event as is the forced foreclosure.