«Longer - term studies of
the effects of aflatoxins will help to shed light on situations of chronic exposure and effects on airways,» they wrote.
However, the downstream
effects of aflatoxins on the airway passage is less studied and understood.
If protein had such a profound ability to protect against the toxic
effect of aflatoxin, however, is it possible that it could also protect against its carcinogenesis?
Not exact matches
Under such conditions [wherein low - protein diets suppress the activity
of detoxification enzymes], the parent compound AFB1 would accumulate to cause greater acute toxic
effects, whereas less product (i.e.,
aflatoxin - DNA adducts) would accumulate to initiate carcinogenesis.
They have been added to livestock feed to prevent the growth
of molds and animal exposure to
aflatoxins, and were found to have a positive
effect on animal health (4).
What is the
effect of protein in animal models where
aflatoxin is fed in small amounts every day?
Effect of Low Protein Diet on Low Dose Chronic
Aflatoxin B1 Induced Hepatic Injury in Rhesus Monkeys.
Effect of High and Low Dietary Protein on the Dosing and Postdosing Periods
of Aflatoxin B1 - induced Hepatic Preneoplastic Lesion Development in the Rat.
J. Cellular Biochemistry, Supplement 22: 169 - 180 Protective
Effect of Curcumin, Ellagic Acid and Bixin on Radiation Induced Genotoxicity K.C. Thresiamma, J. George and R. Kuttan Amala Cancer Research Centre, Amala Nagar, Trichur, India «Inhibitory
effects of ellagic acid on the direct - acting mutagenicity
of aflatoxin B1 in the Salmonella microsuspension assay.»
«
Effect of dietary protein quality on development
of aflatoxin B [1]- induced hepatic preneoplastic lesions,» published in the August 1989 edition
of the Journal
of the National Cancer Institute.
The results
of this earlier experiment were published in a paper called «
Effect of Low Protein Diet on Low Dose Chronic
Aflatoxin B1 Induced Hepatic Injury in Rhesus Monkeys» in 1989.
Much
of it is based on a study he helped conduct: «
Effect of dietary protein quality on development
of aflatoxin B [1]- induced hepatic preneoplastic lesions,» published in the August 1989 edition
of the Journal
of the National Cancer Institute.
In one intriguing paper titled «
Effect of Low Protein Diet on Chronic
Aflatoxin B1 - induced Liver Injury in Rhesus Monkeys,» the researchers describe something that undermines the conclusions Campbell drew from his own research.
When rats were all fed 20 % casein, the dose that provided the maximal cancer - promoting
effect, those dosed with 0.4 milligrams per kilogram body weight (0.4 mg / kg) or 1.0 mg / kg
of aflatoxin failed to develop any pre-cancerous lesions at all.
Effect of Dietary Protein Quality on Development
of Aflatoxin B1 - Induced Hepatic Preneoplastic Lesions.
1983 May; 43 (5): 2150 - 4
Effect of high and low dietary protein on the dosing and postdosing periods
of aflatoxin B1 - induced hepatic preneoplastic lesion development in the rat)
1968 Feb; 85 (2): 133 - 7 The
effect of dietary protein on carcinogenesis
of aflatoxin)
Campbell sometimes took the increased toxicity
of aflatoxin into account in his papers, but it's amazing that 1) this disappeared from his papers in the 1990s and consequently in [i] The China Study [/ i] and that 2) he [i] never [/ i] investigated the protective
effect of the 20 % casein diet during the initiation period.
«
Effect of low protein diet on low dose chronic
aflatoxin B1 induced hepatic injury in rhesus monkeys.»
More clues for understanding the casein - cancer research come from another Indian study — this one published in the late 1980s, and examining the
effects of protein in
aflatoxin - exposed monkeys instead
of rats.14 As with Campbell's experiments, the monkeys were fed diets containing either 5 percent or 20 percent casein, but with one important difference: instead
of being slammed with an astronomically (and unrealistically) high dose
of aflatoxin, the monkeys were exposed to lower, daily doses — mimicking a real - world situation where
aflatoxin is consumed frequently in small amounts from contaminated foods.
Another study from Turkey (13) shows the protective
effect of boric acid on food contaminated with mycotoxins, especially fungal
aflatoxins.
Aflatoxin has a variety
of effects on the body.