Side
effects of cancer immunotherapy will vary depending on which type of immunotherapy is used.
Not exact matches
Editor's note: This story was updated June 21, 2017, to correct the list
of side
effects of the treatment and to note that it's not just late - stage
cancer patients who might be eligible for
immunotherapy.
Immunotherapy doubles overall survival and improves quality
of life, with fewer side
effects, in a treatment - resistant and rapidly progressing form
of head and neck carcinoma, reports a large, randomized international trial co-led by investigators at the University
of Pittsburgh
Cancer Institute (UPCI).
These therapies could enhance the
effects of novel
cancer immunotherapies when used in combination, resulting in better health outcomes for
cancer patients.
Immunotherapy tries to reset our immune response to recognise these hijacker
cancer cells but these types
of untargeted therapies have many side
effects.
The side
effects of immunotherapy are usually quite different from those
of traditional
cancer drugs used in therapies such as chemotherapy.
Dr Guerra said: «The paradoxical
effect of NKG2D we discovered exposes the need to selectively target the types
of cancer that will benefit from NKG2D - based
immunotherapy.
Schumacher was the first to develop a technology for high - throughput analysis
of immune cell reactivity to
cancer neoantigens, which has allowed researchers to better observe the
effects of immunotherapy in patients and has made it possible to develop personalized, patient - specific
immunotherapies.
The goal is to test if targeting the vitamin D receptor will unlock the potential
of immunotherapies to kill pancreatic
cancer tumor cells and potentially establish a therapeutic combination for controlling advanced pancreatic
cancer, extending patient survival, and reducing patient side
effects.
Areas
of focus include: understanding how tumour - reactive T cells and B cells promote patient survival in
cancer; defining the
effects of standard treatments on tumor immunity; and using genomic approaches to identify novel tumour mutations that can serve as target antigens for
immunotherapy.
The current
immunotherapies are subject to the immunosuppressive
effects of cancer, which likely contribute to their lack
of success.