Sentences with phrase «effects of cancer therapy»
«While there is extensive scientific literature on the late effects of cancer therapy, including the risk that survivors will develop subsequent malignancies, until now little was known about the contribution of genetic factors,» said Jinghui Zhang, PhD, Computational Biology chair.
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«For survivors at risk of breast cancer due to chest radiation or heart problems because of anthracyclines, screening tests like mammograms and echocardiograms that result in early detection of late effects of cancer therapy may make a lifesaving difference,» he said.
He was conducting laboratory experiments aimed at finding ways to lessen the effects of cancer therapy on ovaries when he noticed that healthy female mice seemed to be losing eggs at unsustainable rates.
Not exact matches
Disney said the precise binding of Targapremir - 18a to microRNA - 18a means a cancer drug that follows this strategy would be likely to kill prostate cancer cells without causing the broader side effects seen with many other cancer therapies.
In October 2016, writing in Mathematical Models and Methods in Applied Sciences, the team used a study of cancer in rats to test 13 leading tumor growth models to determine which could predict key quantities of interest relevant to survival, and the effects of various therapies.
On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.
«Urologists tend to prefer to forgo adjuvant radiation therapy, because they fear the side effects, and radiation oncologists tend to prefer offering adjuvant radiation therapy because they fear the risk of metastasis [cancer spreading to other sites in the body],» Showalter said.
For men with intermediate risk prostate cancer, side effects at two years following radiation therapy (RT) were comparable for extremely - hypofractionated treatment, which was delivered in seven fractions across two and a half weeks, and conventional treatment of 39 fractions across eight weeks, according to research presented at the 58th Annual Meeting of the American Society for Radiation Oncology (ASTRO).
Frequent, low - dose chemotherapy regimens avoid this effect and may therefore be more effective at treating certain types of breast and pancreatic cancer, according to the murine study «Metronomic chemotherapy prevents therapy - induced stromal activation and induction of tumor - initiating cells,» which will be published online November 23 in The Journal of Experimental Medicine.
However, other research has suggested that the estrogen - like effects of isoflavones may reduce the effectiveness of endocrine therapies used to treat breast cancer.
Much of the cancer - killing effect of the oHSV injections was lost when the researchers tested the therapy in tumors of mice with defective immune systems.
Before moving on to human trials, they will need to study all instances of «off - target» effects: Years before Crispr, the viruses employed to deliver DNA in gene therapy trials occasionally damaged the whole system, causing cancer.
The second visualization was a movie captured at 23,000 - times magnification that revealed the movements of a group of nanoparticles reacting to an electron beam, which mimics the effects of the infrared radiation used in cancer therapies.
Instead, the therapy may benefit from the activity of the immune system operating in tandem, creating a synergistic, cancer - killing effect.
But for some patients who have received therapy and survived, the risk of dying from the side effects over the long term might be even higher than from the cancer.
He also plans a multicenter / multinational study of patients with melanoma or other types of cancer, to examine the effect of long - term CPAP therapy on those also diagnosed with sleep apnea.
New molecular imaging technologies can make it easier to diagnose, monitor, and treat cancers while potentially saving patients from undergoing therapies that are likely to be ineffective and playing a role in minimizing side effects, according to experts from the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania.
This matters for the optimisation of ion - beam cancer therapy, which requires a thorough understanding of the relation between the physical characteristics of the incoming ion beam and its effects on biological tissues.
«This is why we're diligently working to employ several strategies that we hope will lead us to reaching our ultimate goal of developing the best therapy possible — a therapy that can be given to patients as a first line of defense, greatly reducing the side effects of cancer treatment and leading to a cure.»
One of the challenges in administering cancer therapy is that the treatment designed to destroy the disease can also have a negative effect on healthy, normal tissue.
Such a molecule might also be able to ameliorate the side effects of chemotherapy or radiation therapy of cancer patients.
However, clinical evidence supporting the chemopreventive effect of aspirin therapy on liver cancer remains limited.
«The current study was designed to determine the effect of inhibition of platelet activation and function by aspirin therapy on colon and pancreatic cancer cell proliferation,» the researchers wrote.
These therapies could enhance the effects of novel cancer immunotherapies when used in combination, resulting in better health outcomes for cancer patients.
Survivors should be assessed for physical (e.g.: urinary, sexual, bowel) and psychosocial effects of prostate cancer and its treatment; the focus of assessment should be tailored to the type of cancer treatment received and current disease state to trigger appropriate self - management and clinical management strategies for support and therapy.
«Identifying a cancer driver is crucial for cancer treatment because it allows the use of targeted therapies, which have less side - effects than conventional chemotherapy drugs, against a particular protein,» said Kurokawa.
«Since doxorubicin is one of the cheapest drugs that is effective against many types of cancer but rarely used in colon cancer, the combination therapy could be highly effective in combating colon cancer while drastically lowering risk of cardiotoxic side effects.»
«If the mouse models are indicative of human disease, the combination therapy can increase the proportion of patients who respond to therapy without additional adverse side effects and can improve the quality of life for cancer patients.»
One way of treating cancer is by inhibiting VEGFA, which decreases leakage and edema and improves the effects of chemo - and radiation therapy.
Gwendolyn Thomas, assistant professor of exercise science, is the co-author of a groundbreaking article in the Obesity Journal (The Obesity Society, 2017) about the effects of exercise and physical activity on postmenopausal breast cancer survivors taking AIs — hormone - therapy drugs that stop the production of estrogen.
For her research efforts, Dietrich has registered a number of firsts with journal papers reflecting her work on such diverse topics as: improving cancer therapy through odor and taste intervention; prevention and treatment of obesity by drinking more water; health effects of iron and copper in drinking water; and risks to people over 50 for unhealthy over-exposure to iron in water.
Dietrich's research includes aspects of cancer therapy, obesity, health effects of certain elements in drinking water, and special risks to people over 50.
Immunotherapy tries to reset our immune response to recognise these hijacker cancer cells but these types of untargeted therapies have many side effects.
It's only three patients on a low dose of cells, but San Diego - based Poseida said the results — activity against the cancer and no «cytokine storm» side effects that often come with CAR - T therapy — were good enough to step up to the next dose.
«These studies suggest the potential for dramatically reducing the dose of chemotherapy or radiation and thereby reducing the side effects of standard chemotherapy by enhancing the targeting of cancer therapies using HIV receptor blocking drugs.»
The study suggests that pediatric brain cancer patients may experience similar side effects of molecularly targeted therapies, and may benefit from efforts to remediate any cognitive deficits.
He has co-authored more than 100 scientific papers, abstracts, and letters examining the efficacy, safety and effects of drug therapies for cancer.
DOYLESTOWN, Pa. (January 23, 2018)-- For decades, researchers have tried to target cancer therapies to only the cancerous cells, to avoid the toxic bystander effects of standard chemo and radiation therapy to normal cells.
Moreover, the inhibitory effects of niclosamide on cancer stem cells provided further evidence for its consideration as a promising drug for cancer therapy.
Researchers found that shorter course of radiation therapy may provide lesser side effects for early stage breast cancer patients compared to the long - term treatments.
The side effects of immunotherapy are usually quite different from those of traditional cancer drugs used in therapies such as chemotherapy.
In an FDA statement, Richard Pazdur, MD, director of the agency's Oncology Center of Excellence, said that a careful review of the new dosing regimen shows that the benefits outweigh the risk: «Mylotarg's history underscores the importance of examining alternative dosing, scheduling, and administration of therapies for patients with cancer, especially in those who may be most vulnerable to the side effects of treatment.»
Our surgical oncologists provide the highest - quality cancer care to diagnose and remove tumors, debulk tumors to help make chemotherapy or radiation therapy more effective, and relieve symptoms or side effects of therapies.
Due to its cell killing effect, radiation therapy is widely used as a primary source of treatment for numerous types of cancers.
Research techniques — unique to the Kimmel Cancer Center — allow us to study the effects of radiation therapy in ways never before possible and to image, quantify and measure tumor responses in real time.
The last plenary session of the day tackled cardiovascular health and cancer survivorship, examining cardiotoxic effects of chemotherapy, radiation and hormone therapies.
Now, all breast cancers are classified as estrogen - receptor positive or negative, an important guide to prognosis and therapy, and medications, such as tamoxifen, that can block the effects of estrogen have become important tools in the treatment and possible prevention of breast cancer.
: We conclude that treatment of triple negative breast cancers with growth hormone - releasing hormone antagonists reduces tumor growth and potentiates the effects of cytotoxic therapy by nullifying drug resistance.
The co-delivery of small molecular drugs with nucleic acids can improve gene transfection efficiency, reduce side - effects of these drugs, and achieve the synergistic effect of drug and gene therapy for the more effective treatment of cancer.
«Thus, our findings raise the possibility that the frequent use of antibiotics during a patient's lifetime or to treat infections related to cancer and its side effects may affect the success of anti-cancer therapy.»