In particular, drugs that inhibit production of prostaglandin E2 may curb inflammation and tumor growth, while avoiding the cardiovascular side
effects of drugs such as Vioxx and the gastrointestinal problems of the earlier class of NSAIDs.
Not exact matches
«Hitler was not insane or deranged, or suffering from
drug - induced delusions,» he writes, «or laboring under the
effects of some chronic disease
such as syphilis, or acting in an unresolved hypnotic trance: on the contrary, he was sane according to any reasonable definition
of the term, and fully responsible for his actions.»
The existing
drugs for osteoarthritis cause a high frequency
of stomach ulcers and other side
effects such as high blood pressure.
Many would argue that it's possible for her to feel better without taking
drugs: she could try the «talking cure» (regular sessions with a counselor), or an alternative treatment
such as herbal or light therapy If she goes to an M.D., though, she'll likely carry my a prescription for an antidepressant
such as Prozac or Zoloft — one
of these brave new medicines that promise
such good results with so few side
effects,
We witness examples
of such devastation in our countries
such as through the use
of chemical pesticides and even fertilizers, the deporting
of our mineral wealth by mining transnational corporations, the exploitation
of our workers, women and children and the ill -
effects of drugs, arms sales and even
of some types
of tourism.
The conclusion: given relatively unlimited availability, heroin users will voluntarily stabilize or reduce their dosage and some will even choose abstinence; long - addicted users can lead relatively normal, stable lives if provided legal access to their
drug of choice, and with few side
effects; and ordinary citizens (in Switzerland at least) will support
such initiatives.
When inflammation strikes, we are conditioned into reaching for a quick fix in the way
of pharmaceutical or prescribed
drugs such as aspirin and ibuprofen, temporary panacea's that come with their own adverse side
effects and with long term use have the potential to create a host
of health problems independently.
Many
of the epidural side
effects mentioned below are not improved with low - dose or walking epidurals, because women using these techniques may still receive a substantial total dose
of local anesthetic, especially when continuous infusions and / or patient - controlled boluses (single large doses) are used.34 The addition
of opiate
drugs in epidurals or CSEs can create further risks for the mother,
such as pruritus (itching) and respiratory depression (see below).
Garrison (personal communication) reports that Narcan, which is sometimes needed by the baby to counteract the sedating
effect of pain - relieving
drugs such as pethidine (demorol), given to the mother in labour, can be effectively administered via the mother's veins in third stage, waking up the newborn baby in a matter
of seconds.
1991 An updated version
of the 1963 classic, this book covers topics
such as the
effects of drugs, alcohol, and caffeine on breastfeeding, relactation, working mothers.
Some researchers believe that it may be a combination
of novocaine with other
drugs used in labor and delivery
such as pain medications and not
effects of the anesthetic.
The psychoactive substances bill sought to crack down on legal highs — especially the new generation
of drugs that are designed to mimic the
effects of traditional illicit substances
such as cannabis and ecstasy — which the Home Office says caused 129 deaths in 2015.
Naloxone (brand name: Narcan ®) is a lifesaving medication that can save lives by reversing the
effect of overdoses caused by heroin or other opioids,
such as hydrocodone and oxycodone prescription
drugs.
The studies focused on motor behavior, not mood disorders, but the team found that certain classes
of psychotropic
drugs,
such as the antidepressants known as monoamine oxidase inhibitors, had recognizable, characteristic
effects on behavior.
The U.S. Food and
Drug Administration originally approved the drug in 1999, but subsequent case reports of abnormal behavior in adolescents who used the medication led the agency in 2006 to require that all packaging of the drug include a warning label about potential neuropsychiatric side effects, such as hallucinations, delirium, self - harm and even suic
Drug Administration originally approved the
drug in 1999, but subsequent case reports of abnormal behavior in adolescents who used the medication led the agency in 2006 to require that all packaging of the drug include a warning label about potential neuropsychiatric side effects, such as hallucinations, delirium, self - harm and even suic
drug in 1999, but subsequent case reports
of abnormal behavior in adolescents who used the medication led the agency in 2006 to require that all packaging
of the
drug include a warning label about potential neuropsychiatric side effects, such as hallucinations, delirium, self - harm and even suic
drug include a warning label about potential neuropsychiatric side
effects,
such as hallucinations, delirium, self - harm and even suicide.
Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery
of drugs for other conditions,
such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side
effects of those medications and to make them more effective.
«When one considers the modest decrease in risk
of adverse outcomes associated with the use
of a number
of widely used medications
such as anti-cholesterol
drugs, the
effect sizes seen in this study are really impressive,» said Dr. Memtsoudis.
Some people can manage their symptoms by sticking to a restrictive diet, or using
drugs to remove sugar from their system, but many
of these have side
effects,
such as weight gain.
The long - term side
effects of HIV
drug treatment,
such as increased cholesterol and heart disease, that crop up after 10 or 15 years will still occur.
Panksepp believes that one
of the
effects oxytocin has is to reduce the tolerance
effect that plays
such a devastating role in
drug addiction.
Stated differently, 98
of 100 men treated for five years would receive no benefit from the
drug, yet they would all be exposed to risk
of its potentially serious and fatal side
effects,
such as muscle breakdown and kidney failure.
«Imagine a
drug that could act like Viagra in the inner ear,» says Lin, who notes that clinical trials are already underway to study the
effects of such disease - modifying
drugs.
Such research may help scientists understand the mechanisms that underlie aging and identify promising
drug candidates that mimic the health - promoting
effects of caloric restriction, says NIA's Felipe Sierra.
By targeting different hormones that help the body manage its own insulin levels — and by reducing side
effects such as weight gain — three
drugs recently approved by the FDA avoid most
of the major problems associated with past diabetes treatments.
The JDF Center for Islet Cell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants,
such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive
drugs that often trigger worse side
effects than the disease; and overcoming the technical difficulties
of transplantation.
Thus far,
such side
effects seen in clinical trials have been minor, but it sometimes takes years
of exposure to a
drug before deadly infections show up, he says.
But like Bandelow, he isn't sure
of XBD173's long - term
effects — particularly in cells
such as the testes and adrenal glands that boast very high levels
of the protein the new
drug goes after.
Finally, besides promoting the evolution
of drug - resistant microbes, antibiotics increase the risk
of side
effects such as tendon rupture or kidney damage, and can damage gut and other microbiomes that are essential to overall health.
Initially used to protect against side -
effects such as fractures, there is also some evidence that taking the
drug extends the lives
of women with breast cancer.
In a final year project, MChem undergraduate student Edward Howe, working in Professor David Smith's research team in the Department
of Chemistry at York looked for a way
of eliminating the adverse side -
effects associated pain - killing
drugs, particularly in the stomach, and the problems,
such as ulceration, this could cause patients.
A Chemistry undergraduate at the University
of York has helped to develop a new
drug release gel, which may help avoid some
of the side
effects of painkillers
such as ibuprofen and naproxen.
It is exactly during puberty that substances like
drugs of abuse — alcohol, cannabis, etc. — may induce the most destructive and also persistent
effects on the still developing brain, which may in some cases even result in neuropsychiatric disorders,
such as schizophrenia or addictive disorders.
Such combinations
of drugs that normally have short - term efficacy could achieve an additive, if not a long - term synergistic
effect.
Our next step is to investigate the
effects of targeting the Erk - Ras - ETS pathway in more complex animals,
such as mice, with a view to developing a
drug regime that could be suitable for testing in humans.
Combine your articles on psilocybin and other psychedelic
drugs having beneficial
effects on the brain (
such as 25 November 2017, p 28) with the promising reports
of 40 hertz bass tones and flickering lights reducing the tangles and plaques
of tau and amyloid proteins that are correlated with Alzheimer's disease (6 January, p 6).
«The results
of this study point to the potential for an alternative treatment that avoids the typical
drug side
effects,
such as bloating and electrolyte imbalance, by imitating the body's natural physiology.»
The program works by connecting computer - generated
drug profiles — including mechanisms
of action, clinical efficacy, and side
effects — with information about how a molecule may interact with human proteins in specific diseases,
such as ovarian cancer.
Only about a third
of people with
such symptoms do go on to develop psychosis, however, and antipsychotic
drugs can cause nasty side
effects, so these are rarely given as a preventative.
By controlling the timing
of the interaction, researchers could pinpoint delivery
of the
drug to a precise location, thus preventing side common side
effects of chemotherapy,
such as hair loss or cardiac toxicity.
Approximately one third
of people with epilepsy still experience seizures even when receiving treatment, and currently available anti-epileptic
drugs often have side
effects such as tiredness and dizziness.
The fact that venoms are mixtures
of specifically targeted toxins rather than single toxins is exactly what makes them
such rich sources
of potential
drugs — that's all a
drug is, really, a compound that has a desired
effect on our bodies.
The Johns Hopkins team used a microshell made
of a sugar - based polymer called cyclodextrin to protect the 3BrPA
drug molecules from disintegrating early and to guard healthy tissue from the
drug's toxic
effects,
such as weight loss, hypothermia and lethal hypoglycemic shock.
The finding that a diagnosis but not psychotic - like experiences is associated with low physical activity may reflect aspects
of illness
such as low motivation, but may also reflect sedative or other side -
effects of therapeutic
drugs.
The study, published in the July issue
of the journal Epidemiology, offers benefits over typically used randomized clinical trials, as
such studies are often too small to identify rare side
effects or may be performed in a group
of patients who do not take other types
of medications or have other conditions that could skew the
drug's
effect in a broader group following approval.
«This study showed that inappropriate prescribing
of antibiotics also affects families at a much more practical level,
such as missed days from school and work, side
effects of the
drugs, and costs for extra childcare.
And beyond that, one could make use
of the unparalleled spatial and temporal precision
of light signaling to activate compounds
such as analgesics, cytostatic
drugs or anti-diabetic agents only at sites where they are required, thus minimizing unwanted side
effects.
Cell - based biosensors can simulate the
effect of various substances,
such as
drugs, on the human body in the laboratory.
While climate change may increase the occurrence
of malaria, the
effect can be almost completely offset by adopting control strategies
such as bed netting, spraying and anti-malarial
drugs, according to a paper published in the journal Nature.
Over the short term, people taking a moderate dose
of the
drug got pain relief comparable to that
of morphine, but reported fewer side
effects,
such as vomiting and breathing problems.
Whether they will actually lead to a greater incidence
of the disease will be complicated by factors including control measures, the availability
of drugs, and even other indirect
effects of climate change,
such as population changes, migration and urbanization.