Sentences with phrase «effects of drugs with»

«Therefore, finding a way to balance the need for full disclosure of potential adverse effects of drugs with the desire to avoid inducing nocebo effects is a pressing issue in health care.»

Interactions ANTICHOLINERGIC DRUGS: Theoretically, concomitant use might decrease the effect of drugs with anticholinergic activity, due to the potential cholinergic activity of DMAE.

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

In addition to partnering with Celgene (celg) to better track negative drug side effects, IBM (ibm) is applying its cognitive computing AI technology to recommend cancer treatment in rural areas in the U.S., India, and China, where there is a dearth of oncologists, said Deborah DiSanzo, general manager for IBM Watson Health.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SDrug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the Sdrug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The side effect was first observed earlier this month at the American Society of Hematology conference, where CEODavid Schenkein spoke with CNBC about the safety of one of the molecules in its drug, which was meant to treat pyruvate kinase deficiency, a rare, genetic anemia.

A more leftist system of greater drug price regulation could come with other negative side - effects, Miller continued.

In an editorial accompanying the new study, Dr. Wilson Compton of the National Institute on Drug Abuse in Bethesda, Maryland, and colleagues say policymakers need to understand which parts of medical marijuana laws are tied with positive and negative effects.

The charges suggest that a small group of health - care firms — ones that acquire the rights to drugs and significantly increase their prices — is drawing the scrutiny of regulators and prosecutors, with a possible chilling effect on aggressive drug - pricing strategies.

Martin Shkreli, the founder and chief executive of Turing, said that the drug is so rarely used that the impact on the health system would be minuscule and that Turing would use the money it earns to develop better treatments for toxoplasmosis, with fewer side effects.

If there is a competitive drug market, with limited advantage offered by the new drug in terms of increased effectiveness or reduced side effects, the drug will probably not win substantial market share in its product category.

Drug company scientists develop a drug with a range of physiological effects, none of which are terribly helpful, so the marketers must identify and promote a disease for the drug to treatDrug company scientists develop a drug with a range of physiological effects, none of which are terribly helpful, so the marketers must identify and promote a disease for the drug to treatdrug with a range of physiological effects, none of which are terribly helpful, so the marketers must identify and promote a disease for the drug to treatdrug to treat....

Many would argue that it's possible for her to feel better without taking drugs: she could try the «talking cure» (regular sessions with a counselor), or an alternative treatment such as herbal or light therapy If she goes to an M.D., though, she'll likely carry my a prescription for an antidepressant such as Prozac or Zoloft — one of these brave new medicines that promise such good results with so few side effects,

In effect he was saying that faith is an opiate, that men drug themselves with it, become sleepy, complacent and comfortable through the use of it, and that their main object in going to church is to be sprayed once more with spiritual cocaine so that they may feel less acutely the ills of life and the miseries of men.

The conclusion: given relatively unlimited availability, heroin users will voluntarily stabilize or reduce their dosage and some will even choose abstinence; long - addicted users can lead relatively normal, stable lives if provided legal access to their drug of choice, and with few side effects; and ordinary citizens (in Switzerland at least) will support such initiatives.

With all the commercialization of drugs, promoting made up diseases and disorders, these companies are already brainwashing this country that everyone is sick and if you take there littel pill you can» sleep better, get rid of skin disorders, etc.» The side effects are worse than the dsupposed disorder to begin wWith all the commercialization of drugs, promoting made up diseases and disorders, these companies are already brainwashing this country that everyone is sick and if you take there littel pill you can» sleep better, get rid of skin disorders, etc.» The side effects are worse than the dsupposed disorder to begin withwith.

I do not feel a warm glow when I remember sweating profusely, vomiting with the effects of the inadequate pain - killing drugs and screaming with pain so loudly and so often that by the morning I could barely speak.

Many of his peers think this is their only option and live with a cocktail of drugs to manage the effects.

When inflammation strikes, we are conditioned into reaching for a quick fix in the way of pharmaceutical or prescribed drugs such as aspirin and ibuprofen, temporary panacea's that come with their own adverse side effects and with long term use have the potential to create a host of health problems independently.

The researchers looked at antioxidant and anti-inflammatory effect of virgin coconut oil when supplemented with the anti-cancer drug Methotrexate.

People with kidney disease or who take warfarin should be careful with cranberry intake, as the fruit may increase oxalate excretion in urine and has the potential to increase the effects of certain pharmaceutical drugs.

This diet was meant to keep the digestion clear so as not to bog down the brain with the «drug - like» effects of food (anxiety and stress, negative thoughts like, «am I eating well?»)

Carl Lewis earlier had overcome a bad stomach to win the long jump, with a leap of 28» 5 1/2», from the Soviet Union's Robert Emmiyan (28» 0»), but left a sour - grape taste in a few mouths with remarks on British TV to the effect that some winners in the Worlds had used performance - enhancing drugs.

«No one explained that one of the side effects of this drug was dehydration, which significantly interferes with milk production,» she says.

Drugs may also accumulate (build up) in infants» bodies, with the effect of contributing to serious organ damage or death.

The whole concept that drugs are always and inevitably «dangerous», while anything «natural» [whatever that is] is safe and benign while having as good an effect as the «unnatural» and dangerous «drug» [a word with connotations of narcotics and addiction, btw] is a very subtle and pervasive concept indeed.

Although amoxicillin is safe for most babies and situations that call for antibiotics, there is a chance of side effects, like with most drugs.

Although none of the groups reported on drug side effects, while Guo who tested only breastfed infants reported on significant decrease in infant crying, and decrease in depressive symptoms at one month and at two months respectively, Sung who tested both formula fed and breastfed infants reported on increase crying in the probiotic treated infants (particularly in the formula fed infants) compared to placebo with no effect on maternal depressive symptoms.

Many of the epidural side effects mentioned below are not improved with low - dose or walking epidurals, because women using these techniques may still receive a substantial total dose of local anesthetic, especially when continuous infusions and / or patient - controlled boluses (single large doses) are used.34 The addition of opiate drugs in epidurals or CSEs can create further risks for the mother, such as pruritus (itching) and respiratory depression (see below).

FDA: «FDA Drug Safety Communication: Reports of a rare, but serious and potentially fatal adverse effect with the use of OTC benzocaine gels and liquids applied to the gums or mouth.»

However, the pain of the surgery mixed in with their pregnancy hormones and the side effects of the drugs which they unfortunately had to take, it very stressful all around.

«The problem with routine prescription of prenatal Rhogam is that many babies who are Rh negative like their mothers will be exposed to the drug, and there has been no systematic study of the long - term effects of this product in babies.

What if a laboring mother is just «immune» to the effects of anesthetic drugs meant to help numb the nerves that deal with the pain of labor contractions?

The finding, published in the November issue of the Archives of General Psychiatry, suggests that breastfeeding mothers with clinical depression may not have to risk the possible side effects of antidepressant drugs on their infants.

FDA Drug Safety Communication: Reports of a rare, but serious and potentially fatal adverse effect with the use of over-the-counter (OTC) benzocaine gels and liquids applied to the gums or mouth.

Choose an obstetrician or health care provider Interview potential doctors Contact health insurance company about coverage Start and pregnancy and birth budget Discuss financial effects of pregnancy and baby with partner Stop smoking Stop drinking Stop using street drugs Talk to your physician about any prescription medications Drink at least 8 glasses of water every day Visit the doctor at least once per month or every 4 weeks Do not dye or perm hair Stop drinking coffee and other caffeinated beverages Exercise daily Start taking prenatal vitamins Eat foods rich in folic acid Eat iron rich foods Increase daily intake of whole grains, fruits and vegetables Nap as much as possible as fatigue is common Eat fish with low levels of mercury no more than 2 days per week Do not eat undercooked meats Do not eat unpasteurized dairy producs Do not eat cold cut deli meats Allow someone else to clean out the kitty litter, if applicable Limit exposure to chemicals Try to limit stress and tension Complete all prenatal tests — HIV, Chlamydia, Gonorrhea, Anemia, Blood Typing, Sickle Cell Anemia, Urine Screening and Rubella.

In addition, the long - term effect of psychoactive drugs on the nursing infant should be handled cautiously, with risk - benefit counseling, and possible monitoring of infant growth and neurodevelopment.

Some researchers believe that it may be a combination of novocaine with other drugs used in labor and delivery such as pain medications and not effects of the anesthetic.

Mothers should enter into labor and delivery informed about the stages of labor, drug - free ways to cope with labor pain, potential side effects of labor medications, and benefits for mother and baby of immediate and exclusive breastfeeding.

«Baroness Smith of Basildon to move that this House regrets that Her Majesty's Government's plans for the introduction of the draft Misuse of Drugs Act 1971 (Amendment)(No. 2) Order 2014 do not include provisions for a 12 - month review of the impact of the reclassification of khat in view of the highly unusual community focus of its use, for putting a detailed policing strategy in place before a ban takes effect, or for a health strategy to prevent a transfer of addiction to other substances; and do not commit the Department for International Development to do more work with the government of Kenya to alleviate the effect of the reclassification on the Kenyan economy.»

Following an investigation by the ACMD the government brought a range of «legal highs» under control of the Misuse of Drugs Act with effect from 23rd December 2009.

The committee recommends the issues of criminality and how much harm a drug causes be completely separated, with the Advisory Council on the Misuse of Drugs (ACMD), which advises ministers on classification, focusing primarily on its clinical and social effects.

Williams says his meetings with lawmakers was a good opportunity to educate lawmakers that have an half - baked perception of the drug's effects.

He says children with Dravet's syndrome need an oil extract of a specific strain that does not contain THC, which is the component in marijuana responsible for most of the drug's psychological effects.

Invited participants include: Senator David Valesky; Assemblyman Mark Gjonaj; Councilman Ritchie Torres; Councilman Andrew Cohen; Public Advocate Letitia James; Deputy Bronx Borough President Aurelia Green; Special Agent in Charge of the U.S. Drug Enforcement Administration, New York Division, James J. Hunt; FBI Assistant Special Agent in Charge, Violent Crimes Division, Michael Osborn; Interim Medical Director of Behavioral Health at HHC, Dr. Charles Barron; NYC DOH Commissioner Mary Basset; NYC DCA Commissioner Julie Menin; President of NYSCOPBA Michael Powers; Representatives from New York, Queens, Kings and Bronx county district attorneys» offices; and parents dealing with the devastating effects of K2.

As I speak to you, some of his colleagues who had contact with him have been quarantined and some of them have started taking drugs to ensure the effects is not felt.

«Our approach was to work with those that developed nusinersen to identify a way to boost their drug's effects on the sickest of the sick.»

The most common side effects of the drug include respiratory infections and constipation, with possible chances of reduced platelet levels and kidney damage.

Disney said the precise binding of Targapremir - 18a to microRNA - 18a means a cancer drug that follows this strategy would be likely to kill prostate cancer cells without causing the broader side effects seen with many other cancer therapies.

The researchers will be looking to correlate AR - V7 with response to galeterone and to see what effect the drug has on the length of time patients survive without their disease progressing.