Despite strong support for the proliferative and growth - promoting
effects of estrogens on mammary epithelial cells from animal and experimental studies (78, 79), previous studies on the associations between estrogens and breast density showed largely null or inconsistent results.
Meanwhile, some reports have shown that
the effects of estrogens on the thyroid gland may be indirect through the pituitary - thyroid axis [18] or as a consequence of increased serum levels of thyroxin binding globulin and the associated changes in thyroid function [23].
Nicole Sekula: Rapid
effects of estrogens on visual processing in male Carassius auratus (Advisor: R. Thompson)
Rapid
effects of estrogens on visual processing in male goldfish, Carassius auratus.
No one has yet studied
the effects of estrogen on wild songbird populations.»
Ana Soto, professor of cellular biology at Tufts University School of Medicine, and her colleagues were studying
the effects of estrogen on a breast cancer cell line.
«A number of scientists are working on
the effect of estrogens on pancreatic insulin - producing cells,» says Sandra Handgraaf, a researcher at the Faculty of Medicine and the first author of this work.
But she notes that progestin is thought to counteract
the effects of estrogen on brain tissue and that estrogen taken by itself may yet be good for the brain.
Some examples of the scholars» projects are:
effects of estrogen on cardiac fibrosis after myocardial infarction, depression and the growth - hormone axis, substance abuse, stress and nicotine, cardiovascular risk in spinal cord injury, and pharmacogenomics and the treatment of breast cancer in elderly women.
Some researchers have speculated that
the effect of estrogen on cognitive aging might differ depending on when exposure occurs.
«Our data further suggest that, despite the historical bias toward
the effects of estrogen on the estrogen receptor, it's the progesterone receptor that dominantly controls estrogen receptor activity when both receptors are present and activated.»
Hyperglycemia inhibits antiproliferative
effects of estrogen on vascular smooth muscle cells.
The cancer promoting
effects of estrogen on breast tissue are restricted by lignan compounds which bind to estrogen receptors.
Turmeric not only tackles the environmental cause of man boobs by blocking
the effects of estrogen on a cellular level, and helping to boost testosterone, but it also has a big impact on your genes.
Diverting attention from the fact that iodine is the active ingredient in seaweed against the carcinogenic
effect of estrogens on female reproductive organs and against many other diseases of the Western World, while pointing to some other factors in seaweed eliciting these beneficial effects.
Vegetables also contain compounds that help reduce
the effects of estrogen on your body.
Many studies have shown that regular consumption of phytoestrogen containing food reduces cancer by reducing
the effect of estrogen on the body.
So yes, genistein in soy can mimic
the effect of estrogen on ERα at high doses.
The beneficial
effects of estrogen on these discomforts are indisputable, but as women become more informed they see that the risks — especially of breast cancer — may be too great to justify its use.
Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial
effect of estrogen on exercise - induced myocardial ischemia in postmenopausal women.
The protective
effects of estrogen on the cardiovascular system.
Evidence suggests that
the effect of estrogen on the cardiovascular system may depend on the system's underlying health, says Henderson, who coauthored an editorial accompanying the new study.
Under consideration will be
the effects of estrogen on memory and learning, as well as the differences between naturally occurring (endogenous) estrogen production in the body and manufactured estrogen consumption by way of pharmaceuticals.
BPA is an endocrine disruptor, meaning it mimics
the effects of estrogen on the body and has been linked to the growth of tumors in the breast, uterus and prostate, impacts on pregnancy and fertility and disruption of the sexual development of the fetus that can cause cancer later in life.
Not exact matches
Scientific research has also questioned the potential health
effects of a regular soy - based diet
on infants due to its
estrogen - like
effects.
Estrogen is thought to be protective
of heart health through its beneficial
effects on cholesterol and because it increases the flexibility
of blood vessels and arteries, allowing them to accommodate blood flow.
This National Institutes
of Health - funded study examined the
effect of estrogen replacement
on mental processes, including memory, in 29 amenorrheic female athletes ages 14 to 25 years compared to 19 who received no
estrogen replacement.
... Larger studies with hormonal assessments and long - term follow - up are needed to better understand the
effect of concussion
on the HPO axis and potential implications for menstrual patterns,
estrogen production and any persistent consequences,» the article concludes.
The reward center
of the brain is much more attuned to the pleasurable
effects of alcohol when
estrogen levels are elevated, an
effect that may underlie the development
of addiction in women, according to a study
on mice at the University
of Illinois at Chicago.
Previous studies
of postmenopausal women have suggested the beneficial
effect of estrogen therapy
on muscle mass and function.
This structurally unique ligand turns
on the body's
estrogen receptors without the negative
effects of excessive
estrogen.
Their study, conducted in 400 healthy men ages 20 to 50, found that higher levels
of testosterone led to lower levels
of HDL cholesterol, or «good» cholesterol, but
estrogen appeared to have no
effect on HDL cholesterol.
To measure the
effect of estrogen therapy
on working memory under stress, Ycaza Herrera recruited 42 women with an average age
of 66 from the USC Early versus Late Intervention Trial with Estradiol led by Howard Hodis, a professor at the Keck School
of Medicine
of USC and a coauthor
of the new study.
Gwendolyn Thomas, assistant professor
of exercise science, is the co-author
of a groundbreaking article in the Obesity Journal (The Obesity Society, 2017) about the
effects of exercise and physical activity
on postmenopausal breast cancer survivors taking AIs — hormone - therapy drugs that stop the production
of estrogen.
The first
estrogen bioassay, (a bioassay is a measurement
of the potency
of a substance by its
effect on living cells or tissues), is developed for use in pharmaceutical research.
Effect of 17β - estradiol and flavonoids
on the regulation
of expression
of newly identified
estrogen responsive genes in a rat raphe nuclei - derived cell line.
Therefore, the mechanism proposed behind decreased female central insulin sensitivity is a modulation caused by brain
estrogen signaling, potentially mediated by
estrogen effects on ERα in various regions
of the hypothalamus.
The
effects of androgens and
estrogens on preadipocyte proliferation in human adipose tissue: influence
of gender and site
Moreover,
estrogen can exert direct
effects on fat tissue by enhancing proliferation
of preadipocytes, especially in females (232), and by up - regulating sc α2A - adrenergic receptors promoting SAT accumulation, notably in premenopausal women (233).
No noteworthy interactions with age, race / ethnicity, body mass index, prior hormone use, smoking status, blood pressure, diabetes, aspirin use, or statin use were found for the
effect of estrogen plus progestin
on CHD, stroke, or VTE.
Functional magnetic resonance imaging and
estrogen effects on the brain: cautious interpretation
of a BOLD finding
Susan Amara, USA - «Regulation
of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation
of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses
of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology
of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy
of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis
of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms
of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic
effect of beta adrenergic stimulation; cardiovascular function
of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and
Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tran
Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation
of Vascular Tone, Adipose Tissue Regulation
of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization
of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions
of Biologically Active Components
of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology
of G protein - coupled receptors, in particular opioid receptors, regulation
of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design
of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors
of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution
of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin,
estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tran
estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation
of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function
of GABA - A receptors; mode
of action
of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus
on AD Mary Vore, USA - Activity and regulation
of expression and function
of the ATP - binding cassette (ABC) transporters
We are currently trying to identify the membrane receptors that mediate rapid
effects of androgens and
estrogens on behavioral and physiological processes related to courtship in goldfish, as well as to determine if these steroids rapidly affect early stages
of sensory processing in ways that amplify neural responses to social stimuli.
For severe cases, doctors sometimes prescribe Danazol, a steroid derivative that decreases levels
of the reproductive hormones FSH and LH, or tamoxifen, a breast - cancer drug that helps relieve breast pain by blocking
estrogen receptors, thus preventing
estrogens effect on breast tissue.
Green tea has a significant
effect on estrogen because
of one component called «sex hormone binding globulin» (SHBG) found in the tea.
The bad: When you lose
estrogen, you lose its protective
effects on your heart and bones, so your risk
of osteoporosis and heart disease rises.
«Whether you're nursing or perimenopausal or menopausal, a lack
of estrogen has a direct
effect on your vaginal tissue,» explains Dr. Dweck.
Your body has to maintain a delicate balance
of hormones at the right time, and when
estrogen is at the optimal level, it has a calming
effect on the brain.
Although
estrogen, a key component in most forms
of hormonal birth control, doesn't directly cause weight gain, it might be the reason a woman doesn't feel as full after she eats — thanks to
estrogen's
effect on hormones that affect appetite, explains nutritionist Alisa Vitti, founder
of FLOliving.com.
«These results suggest that phytoestrogens can interfere with the normal
estrogen feedback mechanisms with respect to release
of gonadotropin in the ewe... although most studies into the
effects of phytoestrogens have concentrated
on changes in the reproductive tract, there are indications that they interfere with the hormone balance between the ovaries and the hypothalamo - adenohypophysical system... ewes
on phytoestrogens have shown follicular abnormalities such as numerous small follicles, deficient antrum formation and signs
of early atresia... it is possible that the permanent changes brought about by phytoestrogens in the brain are a result
of these compounds interacting with
estrogen receptors in this tissue, and subsequently influencing the re-synthesis or replenishment
of cyto - plasmic
estrogen receptors... phytoestrogens can interfere with the delicate feedback mechanisms involved in the release
of the gonadotrophins.»