Sentences with phrase «effects of inflammation on»

«Our findings determine the potential negative effects of inflammation on stem cell function as they're currently used.

Not exact matches

Just look at this list of benefits from a recent study done at the Yale - Griffin Prevention Research Center by David L. Katz, MD, and his colleagues: «Cocoa can protect nerves from injury and inflammation, protect the skin from oxidative damage from UV radiation... and have beneficial effects on satiety, cognitive function, and mood.»

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Metabolic inflammation is the inappropriate activation of your immune system, which can disrupt many of your body's systems and can have severe effects on weight retention and weight gain.

Perhaps the most important yet most overlooked benefit of intermittent fasting is its effect on reducing inflammation and waste from the body.

Thats really a very good fruit giving énergumène helping intestin with fibers and a very effect on inflammations of muscles my mother who is 86 is really addict with this fantastic pouder

In fact, one of the primary studied benefits in this regard is the effect that cacao has on improving insulin resistance and downregulating inflammation caused by obesity (6).

Results: Daily ingestion of wheat - based starch hydrolysates, glucose syrups and maltodextrins, had no deleterious effect on small - bowel mucosal villous architecture or inflammation in coeliac disease patients when compared to the placebo group.

To investigate the effect of various parenting styles on kids» health, researchers at the University of Oregon examined saliva samples of 102 children who had an average age of 9 to look for levels of C - reactive protein, which measures general inflammation in the body, and secretory immunoglobulin A, which measures immune system activation.

While we don't know the long - term effects of unhealthy fats on infant cardiovascular health, we do know that in adults these fats negatively affect heart health by raising LDL (bad cholesterol), lowering HDL (good cholesterol), and increasing signs of inflammation.

The effects of antibiotics on toothache caused by inflammation or infection at the root of the tooth in adults

In addition, many studies do not take into account the complex interaction of different fatty acid subtypes, such as omega - 3 and omega - 6 fatty acids, on gut inflammation as well as their effect on the intestinal microbiome.

E-cigarette vapors also «produced mild effects on the lungs, including inflammation and protein damage,» notes Thomas Sussan of the Johns Hopkins Bloomberg School of Public Health, lead author of the study, published February 4 in PLOS ONE.

«Treating psoriasis patients with IL - 17 blockers — some already on the market — could have a beneficial effect on the loss of bone tissue, unlike other compounds that might only affect skin inflammation,» says Uluçkan.

Disease - driving mechanisms vary and include, among others, the pruning of neuronal synapses, effects on CNS development in utero, and inflammation.

«Actively treating bodily inflammation in middle age and beyond may lessen the effects of these conditions on the brain's decline in old age.»

These effects included suppression of naturally secreted antimicrobials and the ability to turn on several genes that promote inflammation.

Dr. Wang plans to continue studying the effects of TNF and IL - 17 on melanocytes, and would like to expand the research to 3D skin models — fabricated samples of tissue in vitro that behave like human skin — that would give a better visual of how the melanin production process is being disrupted by these two cytokines during skin inflammation or wound healing.

Activation of NOTCH1 by blood flow causes a domino effect, triggering numerous other genes in the network to turn on or off, resulting in suppression of inflammation and calcification.

The findings suggest that by promoting chronic inflammation through their effect on fat cells, staph superantigens may play a role in the development of diabetes.

Although the reasons why colonoscopy increases the risk of appendicitis remain unclear, the article offers some theories, including asking if bacteria within the colon are altered as the bowel is prepared prior to colonoscopy in ways that increase the likelihood of inflammation, or if the increased air pressure caused by colonoscopy may have effects on the colonic mucosa that can predispose people to appendicitis.

In a study that has implications for humans with inflammatory diseases, researchers from Case Western Reserve University School of Medicine and colleagues have found that, given over a six - week period, the artificial sweetener sucralose, known by the brand name Splenda, worsens gut inflammation in mice with Crohn's - like disease, but had no substantive effect on those without the condition.

In addition to effects on the brain, Brody's research with the SAAF participants has found they have lower levels of stress hormones circulating in their bodies, they have lower levels of inflammation, and they are less likely to show biological markers of premature aging.

Most products on the market today that are used to treat skin problems target the effects of the disease or wound such as inflammation, which can prolong the healing process and result in scarring.

These trends may be explained in part by the yo - yo effects that high glycemic - index carbohydrates have on blood glucose, which can stimulate fat production and inflammation, increase overall caloric intake and lower insulin sensitivity, says David Ludwig, director of the obesity program at Children's Hospital Boston.

Looking beyond provocative findings like those in Finch's study, Tracy and other researchers on aging say that it may be too simplistic to think of inflammation in terms of straightforward cause and effect.

In addition to cholesterol, eggs contain many beneficial nutrients that can have an effect on, for example, glucose metabolism and low - grade inflammation, and thus lower the risk of type 2 diabetes.

In her most recent paper, Ennis describes how her team looked at the effects of ultra-dilute solutions of histamine on human white blood cells involved in inflammation.

The researchers also set parameters to assess the impact of the effects of the high - fat, high - calorie diet on mouse pancreas tissue, such as increased inflammation and other biological signs that indicate pancreas problems.

There were no signs of toxic effects on the eye, either in terms of inflammation / infection or on the cellular level.

Walker said that the effect of one standard deviation increase in the overall inflammation score in mid-life on brain volume decades later was similar to the effect associated with having one copy of the apolipoprotein E (APOE) e4 gene that increases the risk of Alzheimer's disease.

Effect of Vegan Fecal Microbiota Transplantation on Carnitine and Choline ‐ Derived Trimethylamine ‐ N ‐ Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome — Loek P. Smits — Journal of the American Heart Association

Ma, X., Ma, X., Ma, Z., Wang, J., Sun, Z., Yu, W., Li, F., Ding, J. «Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation in a chronic asthmatic mouse model».

They discovered that giving the mice antibiotics produced very different effects on their gut microbiomes, as well as on their insulin sensitivity, tissue inflammation and related metabolic functions such as blood glucose, depending on the genetic background of the mouse.

Surprisingly, the effects of obesity on gut bacteria, inflammation, and osteoarthritis were completely prevented when the high fat diet of obese mice was supplemented with a common prebiotic, called oligofructose.

It's no secret that smoking is harmful, but it's been hard to study its effects on chronic obstructive pulmonary disease (COPD), a disease that leaves sufferers short of breath thanks to inflammation of the small airways in the lung.

The trial was designed to examine the effect of various doses of DG031 on certain biomarkers linked to arterial inflammation and risk of heart attack in patients with a history of heart attack and one or more of the gene variants deCODE has linked to increased risk of the disease.

Complementary effects of cereal and pulse polyphenols and dietary fiber on chronic inflammation and gut health — Joseph M. Awika — Food & Function

One of the clearest scientific evidence about the action of CBD on skin inflammation is entitled «Cannabidiol produces sebaceous and anti-inflammatory effects in human sebocytes.»

Although it was not the primary endpoint of our analyses, we took the opportunity to assess whether exercise, which is known to have anti-inflammatory effects, might reduce gliosis and inflammation in Grn − / − mice, which would be independent of an effect on progranulin levels.

The efficacious quality of RIPK2 inhibitor 1 in resolving intestinal inflammation may arise from the fact that it can have a small but significant effect on TNFα -, IL - 1β -, and LPS - driven NFκB activation as seen in Fig. 5 and Supplemental Fig. 3B.

He did his Ph.D from University of Pune in Biotechnology in identifying posttranscriptional regulation of cytokine IL - 10 and its effect on allergic airway inflammation.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

While at Stanford, I was awarded a Howard Hughes Medical Institute (HHMI) fellowship award for research into the effects of inflammation and radiation on neural stem cells.

Some questions we're all still trying to answer include the composition of the gut microbiota, its effects on the permeability of the lining of the gastrointestinal tract, its effects on whole - body inflammation, and its effects on neuronal signaling from the gut to the brain.

In a study that has implications for humans with inflammatory diseases, researchers from Case Western Reserve University School of Medicine and colleagues have found that, given over a six - week period, the artificial sweetener sucralose, known by the brand name Splenda, worsens gut inflammation in mice with Crohn's disease, but had no substantive effect on those without the condition.

The effects of inflammation aren't just internal: They can also be reflected on your skin.

It also appeared to lower levels of a marker of inflammation found in the blood of people with Alzheimer's (called high - sensitivity c - reactive protein)-- although it had no effect on other biomarkers of cell damage or inflammation.

In addition to fresh produce, focus on other foods that help cool inflammation instead of processed foods, which have the opposite effect.

There have also been some preliminary studies on the effects of grounding on cortisol levels and inflammation (PDF) and I'm confident that research will continue in this area.