Sentences with phrase «effects of osteocalcin»

Although the metabolic effects of osteocalcin are still being elucidated (58, 59), several studies suggest that undercarboxylated osteocalcin regulates glycemic control and lipid metabolism in mouse models (27, 30, 60).

Not exact matches

To find out if this effect on testosterone production might affect mice's fertility, the team knocked out the gene for osteocalcin in a group of the rodents.

Osteocalcin's effects appear to be dependent on the expression of RbAp48.

Although the metabolic responses observed are consistent with the cellular consequences of osteocalcin exposure in pancreatic β - cells and myoblasts in vitro (27 — 29, 61), the metabolic effects of exercise and WBV may not be dependent on osteocalcin per se.

In the present studies, the effects of musculoskeletal loading on serum osteocalcin in db / db mice were correlated with improvements in glycemic control and insulin sensitivity, but it is important to note that total, rather than undercarboxylated, osteocalcin was measured here.

As mentioned above, genetic or pharmaceutical interventions to increase or decrease bone resorption not only controlled the release of undercarboxylated osteocalcin, but also produced the expected effects on energy metabolism and testosterone.

* Oddly enough, however, the experiments with fresh pancreatic islets and fat cells taken from the mice suggested that the positive effects of uncarboxylated osteocalcin on insulin only occurred at concentrations extremely low compared to those of undercarboxylated osteocalcin normally present in mice, while the effects on adiponectin and energy expenditure only occurred at normal to high concentrations.

The Opotowski team, which found that low vitamin A levels had as great an effect lowering BMD as did high vitamin A levels, suggested that vitamin A deficiency may contribute to increased fracture risk by allowing bone matrix to grow faster than it can be mineralized.12 Indeed, although the net effect of vitamin A is to stimulate osteoclasts and slow the growth of osteoblasts, vitamin A also causes osteoblasts to secrete a variety of enzymes and other proteins that are important to bone mineralization, including osteocalcin, which is a protein that plays a direct role in attracting and binding calcium within the bone matrix.6 By slowing the growth of the matrix but increasing the rate at which it is mineralized, adequate vitamin A helps to ensure sufficient bone density.