Sentences with phrase «effects of the alterations»

Insight into the processes to which these genes contribute is exploding as researchers assess the effects of the alterations, and pharmaceutical companies are using the resulting mouse models of disease to develop drugs.

The special body company, assembler, equipment installer, or upfitter is solely responsible for warranties on the body or equipment and any alterations (or any effect of the alterations) to any of the parts, components, systems, or assemblies installed by GM.

The special body company, assembler, equipment installer, or upfitter is solely responsible for warranties on the body or equipment and any alterations (or any effect of the alterations) to any of the parts, components, systems, or assemblies installed by Volkswagen.

Ability to use analytical methods, to evaluate the effect of alterations in regulations on operations

Not exact matches

Because gene drives can pass such changes down from one generation to the next, each potential alteration in the code of life could have a lasting and unknowable effect.

These tiny alterations can sometimes give you the desired effect of a large - scale renovation — without the large - scale cost.

Radiation waves, genetic alteration of food and drastic changes in the traditional diet may have a cumulative effect.

Some have supposed that he changed God's attitude toward man or effected some alteration in the power of evil over the world.

Liberty's decision to make these rule changes may seem minor in the wake of the enormous, sport - ruining alterations it made in the off - season, like changing the F1 logo and getting rid of grid girls, but they're likely to have a profound effect on the racing going forward.

These activities can have harmful environmental effects including draining of wetlands, destruction of amphibians and reptiles by heavy equipment, erosion and sedimentation, and other, permanent or long - term alterations of productive wildlife habitat.

She found that milestone achievement was abnormal in these monkeys: at six to eight weeks they were slow in starting to manipulate, and at ten months the increase in «motor disturbance behaviors» that normally occurs was prolonged.101 The author concludes, «These effects could occur as a result of effects on vulnerable brain processes during a sensitive period, interference with programming of [normal] brain development by endogenous [internal] agents or alteration in early experiences.»

Some artists approach the alteration of their cars cautiously and tentatively, opting to use materials of a temporary nature such as paper or tape, while others decide to radically change the original structure of the vehicle so that it in effect becomes a moving sculpture.

Follow - up studies confirm the effect lasts into the toddler years, and researchers have connected the phenomenon to epigenetics, or long - term alterations of DNA function (Sharp et al 2015; Pickles et al 2016).

The Electoral Commission must make any additions, deletions, and alterations to the roll that may be necessary to give effect to the order of the court.

«The minor alterations submitted before the Legislature today involve the re-allocation of approximately $ 1.5 million out of the nearly $ 1.7 billion county budget, and if passed in full as presented today without any further amendment, will be signed into effect by me,» Poloncarz said in a statement.

Sweeping alterations to the electoral map of Britain caused by the coalition's decision to cut the number of MPs from 650 to 600 must be approved by October 2013 at the latest if they are to take effect at the planned 2015 general election.

The aspiring candidates should be advised to have the means of altering or amending their nomination forms ready and by their side to effect the alterations, amendments and corrections at the shortest notice by the Commissioner.

This beneficial effect was accompanied by the preservation of motor capacities, without any alteration to cognitive performance, and a reduction in the incidence of pathologies usually associated with aging, such as cancer or diabetes.

«This interfering effect makes Fano resonances especially sensitive to changes in either of the participating systems: a slight perturbation results in dramatic alteration in the optical characteristics,» says Yu.

Many people have concerns about the possible use of genome editing in humans, for example, about the risks of unintended effects due to off target DNA alterations, and the implications of making irreversible changes that will be passed on to future generations.

In addition, brain imaging studies in rats and humans have shown alterations in gray matter volume and white matter integrity in the brain caused by the effects of chronic pain.

An analysis of published studies and reports indicates that a number of herbal products may affect the properties of prescription drugs, leading to alterations in the drugs» effectiveness as well as potentially dangerous side effects.

In addition, effects of smoking during pregnancy on infant cortisol and stress response were explained by alterations in DNA for a gene that regulates passage of cortisol from mother to fetus.

Together with an international team of physicists, chemists and mathematicians, the researcher has now discovered an unexpected, promising and novel approach: Using the tennis racket effect, a well - known phenomenon in classical mechanics, the consistent alteration in the spin of quanta via electromagnetic control commands can be visualized.

The treated rodents were not only fatter but also suffered elevated levels of fasting insulin, and alterations in genes related to liver regeneration and detoxification — effects consistent with metabolic disorders in obese patients.

The effects of consuming emulsifiers were eliminated in mice devoid of microbiota (germ - free mice), and transplanting microbiota from emulsifier - treated mice to germ - free mice was sufficient to transfer alterations in intestinal epithelial cells» homeostasis, suggesting a central role played by the microbiota in tumor development.

He suggests that combining genomewide and epigenomewide association studies can overcome problems of assigning cause and effect to specific alterations among either type of study alone.

So this language in effect means alterations of embryonic cells can not be done in the United States if there is any intent to treat a human being, including implantation of an altered embryo into a woman's uterus.

The virulence effects of H pylori have been shown to derive from bacterium factors causing alterations in gastric epithelial cells.

To examine alterations in brain activation associated with pharmacologically induced memory impairment, we used functional MRI (fMRI) to study the effects of lorazepam and scopolamine on a face - name

In general, genetic polymorphisms result in alterations of pharmacokinetic and / or pharmacodynamics properties which are then reflected in therapy outcomes that range from potentially life - threatening adverse effects to inadequate therapeutic response.

This allows researchers to determine the causal effects on behaviour of temporary alterations in the chemical function of these regions.

Interestingly, estrogen effects within the brain with consequent alterations of leptin and insulin sensitivity could also be verified in male animals after estrogen administration (262).

This effect on growth inhibition was not due to alterations in cell cycle (Supplemental Fig. 5) nor a significant increase in the apoptotic cell populations, suggesting that RIPK2 inhibition of proliferation is independent of cell cycle or apoptotic changes.

The potential risks around sulfate aerosol solar geoengineering include alteration of regional precipitation patterns, its effects on human health, and the potential damage to Earth's ozone layer by increased stratospheric sulfate particles.

It has been demonstrated that the composition of the medium used for embryo culture has a profound effect on the methylation pattern in the resultant two - cell embryos [10], indicating that, in addition to imprinted genes, other epigenetic alterations may intensely modify gene expression.

Even small alterations at the base of the food web can have knock - on effects for higher trophic levels.

New genetic technologies developed over the past decade have helped researchers examine the functional effects of genetic alterations that underlie the development of cancer.

This study describes for the first time that suboptimal IVC affects male fertility and that a paternal IVC effect induces intergenerational transmission of a glucose metabolism alteration and hepatomegaly phenotype to their male offspring, confirming that programming events triggered by preimplantational growth restrictions may induce persistent and transmissible phenotypic abnormalities in subsequent generations.

None of the three healthy volunteers participating in the study got sick, but the alteration of their bacterial ecosystem could have longer - term, subtler effects, he adds.

Protective effects of selenium on fluoride induced alterations in certain enzymes in brain of mice.

Prior research by the same researchers on the effects of glucose and caffeine consumption showed improvements in declarative memory and attention span with no significant alteration of the subjective state of the individuals.

In 2011, researchers in Germany found that exposure to stress was responsible for alterations in gut motility, an increase in intestinal permeability, and negative effects on the intestinal microbiota, as well as the regenerative capacity of the gut mucosa.

These behavioral changes were associated with alterations in the GABA system of the brain in the probiotic group, matching the known effects of antidepressant or anxiolytic chemical agents (for example, anxiolytic agents such as benzodiazepines work at GABA receptors)[91].

As mentioned, the regular consumption of a high - fat diet causes alterations in the characteristics of the intestinal microbiota, yet when antimicrobials are administered along with the Western - style diet, the detrimental diet - induced effects on systemic inflammation, systemic LPS burden and glucose - insulin dysregulation are minimized [21].

Such alterations include avoiding processed foods rich in pro-inflammatory molecules, but also a focus on consuming substantial amounts of foods with documented anti-inflammatory effects, often raw and fresh green vegetables and tubers such as turmeric / curcumin.

This paper, Effect of hypothalamic - pituitary - adrenal axis alterations on glucose and lipid metabolism in diabetic rats, reports that astragalus may improve HPA axis functioning and aid in the treatment of diabetes by lowering blood sugar and high levels of corticosterone (the rat version of cortisol).

This effect appears to be through a decrease in estrogen signaling and an alteration of estrogen metabolism.

These likely contribute to inflammaging and alteration of redox status, which can exert effects on the brain through the age - related increase in bacteria involved in the tryptophan metabolism pathway; findings supported by the demonstrated reduction of tryptophan in the serum of centenarians.

Assessing the effect of grip width, Barnett et al. (1995) explored the difference between the bench press performed with narrow and wide hand spacing, as well as alterations in bench angle.