Side
effects of the treatment included skin rashes, thyroid problems and diarrhea as the therapy caused the immune system to attack other parts of the body.
Side
effects of the treatment included hot flashes, heart palpitations, and burning sensations in the skin, which were reversed by adjusting the DBS settings, according to the study.
Not exact matches
CAR - T
treatments,
including competing products from Novartis rivals Kite Pharma and Juno Therapeutics, come with the risk
of potentially deadly side
effects such as cytokine - release syndrome (CRS), in which a glut
of T - cell - assisting cytokines can cause high fever, low blood pressure, and problems with lung oxygenation.
These risks and uncertainties
include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products,
including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount
of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in
treatment duration; availability
of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction
of generic versions
of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the
effect of lowering prices or reducing the number
of insured patients; the possibility
of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels
of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits
of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products,
including Biktarvy; Gilead's ability to successfully commercialize its products,
including Biktarvy; the risk that physicians and patients may not see advantages
of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development
of Gilead's product candidates,
including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate
of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
Contraindications
of TEOSYAL ® PURESENSE
treatments include pregnancy and breast feeding since the
effect of the injections in these circumstances is not known.
Examples might
include a 30 - year - old healthy woman without a family history
of ovarian cancer wanting to have her ovaries removed to prevent such a cancer; a woman with fibroids wanting an experimental surgical
treatment whose long - term
effects are still unknown; or an 18 - year - old woman without children wanting a sterilization procedure.
While HELLP syndrome is rare,
effecting only 1 or 2 out
of every 1000 births, without early
treatment HELLP syndrome carries with it a high risk
of severe health complications,
including death, for the mother and fetus.
In a trial that
included separate
treatment groups
of nurse and paraprofessional home visitors, the nurses produced
effects that were twice as large as those
of the paraprofessionals.18
In future updates, if more eligible studies are
included, we will explore the impact
of including studies with high levels
of missing data in the overall assessment
of treatment effect by using sensitivity analysis.
The difference in the average
treatment effect in overall fetal loss and neonatal death across
included trials between women allocated to midwife - led continuity models
of care and women allocated to other models has an average risk ratio (RR)
of 0.84, with 95 % confidence interval (CI) 0.71 to 0.99 (participants = 17561; studies = 13).
The difference in the average
treatment effect in all fetal loss before and after 24 weeks plus neonatal death across
included trials between women allocated to midwife - led continuity models
of care and women allocated to other models has an average RR
of 0.84, with 95 % CI 0.71 to 0.99.
The difference in the average
treatment effect in all fetal loss before and after 24 weeks plus neonatal death across
included trials between women allocated to midwife - led continuity models
of care and women allocated to other models has an average risk ratio (RR)
of 0.84, with 95 % confidence interval (CI) 0.71 to 0.99 (participants = 17561; studies = 13).
In future updates we will explore the impact
of including studies with high levels
of missing data in the overall assessment
of treatment effect by using sensitivity analysis.
And at this year's conference, sessions
included «Avoiding Unnecessary Guilt When Breast - Feeding Does Not Happen,» «Medications & Mother's Milk,» «The
Effect of Media Violence on Children» and «Complementary
Treatments to Postpartum Depression.»
The difference in the average
treatment effect in overall fetal loss and neonatal death across
included trials between women allocated to midwife - led continuity models
of care and women allocated to other models has an average risk ratio (RR)
of 0.84 and a 95 % confidence interval (CI)
of 0.71 to 1.00 (12 trials, n = 15,869, RR 0.84, 95 % CI 0.71 to 1.00, random -
effects).
Again, there was some evidence that the
treatment effect may be partly due to bias; sensitivity analysis
including only those studies assessed as being at low risk
of bias for allocation concealment showed that results still favoured the intervention group although the
treatment effect was less pronounced in the studies at lower risk
of bias (Analysis 1.8).
Topics
include the rights
of persons with disabilities; the rights and responsibilities
of drug users and ethical considerations for dignified addiction
treatment; improving maternal and child health through advancements in women's rights; the
effects of violence; access to affordable and appropriate health care and
treatment; health disparities between different population groups; health during war and conflict; the health
of internally displaced persons and refugees; and recognition
of social and structural forces that impact the health
of individuals and groups.
«Most researchers have relied on cell lines to screen the
effect of drugs and other
treatments including viruses,» said Dr. Cripe, who also is a professor at The Ohio State University College
of Medicine.
«Given the current state
of the opioid overdose epidemic, it is critical that patients seeking help for opioid addiction have access to comprehensive
treatment that includes highly effective medications whose effects may be enhanced with the provision of psychosocial interventions,» according to the report by Karen Dugosh, PhD, of Treatment Research Institute, Philadelphia, and c
treatment that
includes highly effective medications whose
effects may be enhanced with the provision
of psychosocial interventions,» according to the report by Karen Dugosh, PhD,
of Treatment Research Institute, Philadelphia, and c
Treatment Research Institute, Philadelphia, and colleagues
While lithium carbonate has been very effective for the
treatment of mania in bipolar disorder, and credited for reducing suicides in depressive phases
of the disease, patients who take lithium carbonate are often noncompliant because
of adverse
effects,
including hand tremor, diarrhea, vomiting, weight gain and decreased thyroid function.
Whilst they are highly effective, they also have numerous disadvantages: in some cases
treatment had to be abandoned due to acute side
effects,
including marked increases
of liver enzymes, with the result that CGRP receptor antagonists have not been approved to date.
New findings by UH biomedical engineer Chandra Mohan and his team raise hope for a new class
of drugs to treat lupus that may not
include the long list
of adverse risks and side
effects often associated with current
treatments.
New findings by a biomedical engineer and his team at the University
of Houston (UH) raise hope for a new class
of drugs to treat lupus that may not
include the long list
of adverse risks and side
effects often associated with current
treatments for this disease.
Possible long - term interventions to reduce mortality and morbidity after high exposures end
include disease screening, reducing important co-exposures,
treatment and health services resource planning, and increasing public awareness
of arsenic health
effects.
The authors address difficulties that arise from conditions
of field implementation,
including the estimation
of treatment effects under partial
treatment implementation, the prevention and analysis
of attrition, analysis
of nested designs, new analytic developments for both regression discontinuity designs and short interrupted time series, and propensity score analysis.
According to researchers, antibiotic resistance and side
effects limit the efficacy
of the current
treatments, which
include benzoyl peroxide, retinoids, antibiotics and Accutane (isotretinonin).
The researchers continue to study the
effects of treatment in both mice and dogs, improve the photoswitch, and develop ways
of attaching the photoswitch to other receptors,
including some that could amplify the signal and allow perception
of fainter light, as occurs normally in rods and cones.
The paper, written by authors at King's College London and Baylor College
of Medicine, reviews contraceptive devices available
including those already used by military and aviation personnel, and calls for more research into the
effect of hormone
treatments on bone mineral loss in space.
Because loss
of bone mineral density is known to occur on spaceflight missions, we need more data regarding health
effects,
including bone health, with long - term use
of hormone
treatments not just for contraception (as most women use them), but also for the less - common use to suppress menses.»
In addition to prevalence estimates, the reports also
include data on cancer
treatment patterns, survival, and information on common short - and long - term
effects of cancer and its
treatment for eleven selected cancers.
«While there are clearly other factors that can cause these types
of abnormalities,
including genetic vulnerabilities, demonstrating that immune activation alone can produce these
effects offers new hope for
treatments that might reduce their severity, or prevent them altogether, in certain individuals.»
If, for example, the crucial
effects of neutrinos were
included in some detailed
treatment, the computer simulations could only be performed in two dimensions, which means that the star in the models was assumed to have an artificial rotational symmetry around an axis.
«This research is important because it identifies a way to reduce some
of what, in medical
treatment, are usually thought
of as THC's unwanted side
effects, while maintaining several important benefits
including pain reduction.»
Both psychotic symptoms and
treatment side
effects are more extreme in other types
of dementia,
including Parkinson's Disease Dementia and Lewy Body Dementia.
But
treatment to reduce 5HT2AR did not change other
effects of THC,
including pain relief.
And yet the majority
of men who are diagnosed via a PSA test end up having
treatment with a high risk
of side
effects including erectile dysfunction, urinary incontinence and heart attack.
Older traditional
treatments that
included interferon and ribavirin were less effective and caused a variety
of side
effects,
including fatigue, as well as flu - like symptoms, depression and lowered blood cell counts.
Other projects
include an analysis
of regional variations
of cancer
treatment in Texas, a study
of the
effect of smoking bans on hospitalization rates, and a study
of whether shared savings programs for physicians can reduce overall patient health care expenditures.
Survivorship
includes issues related to health care access, follow - up
treatment, late - and long - term
effects of treatment, recurrence, and quality
of life.
Active tuberculosis is treatable (and curable), but disease control and
treatment adherence are complicated by a variety
of factors,
including availability
of healthcare resources, multidrug - resistant tuberculosis strains and potentially toxic side
effects of treatment.
The scientists also found that the surgery and radiation
treatments sometimes caused severe side
effects,
including sexual dysfunction, incontinence and bowel problems, that hurt the patients» quality
of life.
For example, mutants may be characterized by comparing their transcript profiles to those obtained in other experiments querying the
effects on gene expression
of many experimental factors
including treatments, mutations and pathogen infections.
Written by two experienced oncology nurses, this compassionate and comprehensive guide explains in plain English everything you need to know about your
treatment,
including what you can expect at each stage
of chemotherapy and what you can do to prevent or minimize side
effects.
Differences in age, hearing level, duration
of tinnitus
of the
included patients, and the condition
of sham
treatment may influence the
effect.
Although effective in the
treatment of anxiety, they can cause significant side
effects,
including orthostatic hypotension (drop in blood pressure on standing), constipation, urinary retention, dry mouth, and blurry vision.
Areas
of focus
include: understanding how tumour - reactive T cells and B cells promote patient survival in cancer; defining the
effects of standard
treatments on tumor immunity; and using genomic approaches to identify novel tumour mutations that can serve as target antigens for immunotherapy.
He also developed the first
treatment protocol for MS involving the transplantation
of stem cells in the U.S. Along with his peers, Dr. Kraft identified the importance
of treating the secondary
effects of MS, known as hidden disabilities,
including cognitive impairments, pain, fatigue, sleep disturbance, and depression.
«A lot
of the
treatments have
effects on sexual health,» Hill said,
including hormone therapy and chemotherapy.
Her current focus is on developing clinical protocols for the
treatment of head and neck and lung cancers with a goal
of providing enhanced tumor control,
including control
of metastases, with minimal
effect of quality
of life.
Urinary problems,
including frequency, urgency, incontinence and pain, are common in patients with prostate cancer, due to the disease itself, and as a side
effect of cancer
treatments like radiation and prostate surgery.