Sentences with phrase «effects of your disease through»

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

The initiative is founded on a developmental origins of health and disease concept (DOHaD) and will examine the cumulative effects of interventions starting preconception and continuing through pregnancy into childhood.

Through continued study, breastmilk has been shown repeatedly to have a wide array of effectiveness against disease - causing agents and lead to an overall positive immunological effect on the health and well being of the infant and mother.

Instead of systematically testing the effects of known compounds — the pharmaceutical industry's basic model for more than a century — scientists can now investigate backward, combing through genomic data to find links between specific genotypes and diseases and then screening drug data to identify therapeutic candidates.

This opposite effect may potentially be used to enhance respiratory capacity in selected disease contexts through therapeutic mimicry of the carrier status.

Williams said, the long - term follow up allowed authors to examine dietary patterns and analyze the effect of gradual adherence to a plant - based diet through reduced animal food intake and increased plant food intake on heart disease risk.

With the brain - on - a-chip platform, Kulp said researchers could analyze how disease spreads through the brain, model epilepsy, or potentially examine the effects of chemical or biological exposure over a timespan of several months.

The FDA approved the combination of Mekinist and Tafinlar through its accelerated approval program, which allows the agency to approve drugs to treat a serious disease based on clinical data showing the therapy has a proven effect and clinical benefit to patients.

Why the disease has such a wide range of effects isn't completely understood, but in recent years a potential cause — the loss of hormone - producing neurons, possibly through an autoimmune response — has been identified.

Albertini replied that there might be subtle health effects, such as early onset of adult diseases like diabetes and cancer, that won't appear until 15 or 20 years after IVF, and he pointed out that there is very little follow - up data on the health of children created through assisted reproductive medicine.

Washington State University researchers say environmental factors are having an underappreciated effect on the course of disease and evolution by prompting genetic mutations through epigenetics, a process by which genes are turned on and off independent of an organism's DNA sequence.

Their findings — that nanotubes and vesicles are an important part of the communications process — show that the extracellular vesicles contribute to the complexity of African trypanosomiasis through the transfer of virulence factors between parasites and inadvertent interaction with host cells, which has a profound effect on disease, the study notes.

PHILADELPHIA --(July 11, 2017)-- Researchers at The Wistar Institute, an international leader in biomedical research in the fields of cancer, immunology and infectious diseases, with collaborators at Indiana University Melvin and Bren Simon Cancer Center and Syndax Pharmaceuticals, Inc., (Nasdaq: SNDX) announce the results of a preclinical study demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MDSCs).

PULLMAN, Wash. — Washington State University researchers say environmental factors are having an underappreciated effect on the course of disease and evolution by prompting genetic mutations through epigenetics, a process by which genes are turned on and off independent of an organism's DNA sequence.

Combining the value of structure - guided Medicinal Chemistry with the confidence that the starting hit achieves its disease - relevant effect through interaction with the target, is an especially powerful approach.

The effect of MSCs in the treatment of autoimmune diseases may be through the induction of de novo generation of antigen - specific CD4 + CD25 + FoxP3 + Tregs 46, 47.

He is interested in elucidating mechanisms of human disease by exploring the functional effects of genetic variation through computational analysis of «- omic» sequencing data.

A Competitor Mounts the Starting Blocks It would be exciting enough for one AS - targeting rejuvenation biotechnology (or one and a half, if PD03A is counted separately) were making such progress through the clinical pipeline, especially in light of the early hints of a disease - modifying effect.

Such treatments, if discovered, could counter not only the effects of mutations in SLC16A11, but also potentially any T2D - associated variants that may trigger the disease through similar mechanisms.

The main goal of these technologies is to accelerate the comprehension of our genome and of human diseases, and to promote therapeutic innovation through the validation of molecular targets and their effects in reference model organisms.

The impact of increased tiger mortality through poaching or human conflict is well known [3], [4], yet the effect of infectious disease outbreaks remains largely unstudied.

Her previous work showed a concerning connection between carrageenan and gastrointestinal cancer in lab animals, and she's involved with ongoing research funded through the National Institutes of Health that is investigating carrageenan's effect on ulcerative colitis and other diseases like diabetes.

Up until now, there were some mixed opinions on the subject — some studies claimed coffee can improve your health and lower the risk of premature death while others claimed that coffee (caffeine) can be a negative factor for your health and can contribute to heart disease through negative effects on blood pressure, resting heart rate and cholesterol.

Chronic exposure to aluminum and melatonin through the diet: Neurobehavioral effects in a transgenic mouse model of Alzheimer disease Food Chem Toxicol.

Conclusion: Our findings suggest that higher vitamin D concentrations, which are easily modifiable through nutritional supplementation, are associated with longer LTL, which underscores the potentially beneficial effects of this hormone on aging and age - related diseases.

The mind - body - spirit effect of yoga, along with the camaraderie and shared information our students experience in one class, can make a huge difference in our students» energy, strength, balance, focus and ability to live their lives to the fullest, rather that to just endure through their chronic disease.

Some phytochemicals that have demonstrated protective effects in both tissue culture and animal models of Parkinson's and neurodegenerative disease through the Keap1 / Nrf2 / ARE pathway include:

Polycystic Ovarian Syndrome Offers insights from leading Polycystic Ovarian Syndrome experts through television and radio programming and local support groups to help women overcome the effects of PCOS and related conditions including infertility, diabetes, cardiovascular disease, anxiety and depression, and hirsutism.

Design: A systematic review of the published literature through January 2015 was performed by using sensitive search strategies to identify randomized controlled clinical trials that evaluated the effects of fasting on either clinically relevant surrogate outcomes (e.g., weight, cholesterol) or actual clinical event endpoints [e.g., diabetes, coronary artery disease (CAD)-RSB- and any other studies that evaluated the effects of fasting on clinical event outcomes.

Nutrition remains important through out life but good nutrition in later years still can help lessen the effects of diseases that prevail among older Americans.

Lyme disease — caused by the bacterium Borrelia burgdorferi — is transmitted to humans through the bite of infected blacklegged or deer ticks, and can have lifelong debilitating effects such as arthritis, fatigue and even neurological deficits.

Some studies have linked coffee consumption to better health and a lower risk of premature death, while others suggest that coffee — or rather caffeine — might contribute to heart disease through negative effects on blood pressure, cholesterol, and heart rate.

A person can be born with an immunodeficiency or acquire it through: infection repeated antibiotic use steroid use (including steroid inhalers) disease malnutrition burns long - term, low - level demands increased immunoglobulin response as a side effect of different pharmaceuticals that can suppress the immune system An immunodeficiency could cause your test results to be inaccurate, giving a false negative.

First, most of the evidence regarding the disease effects of carbohydrate to fat ratio is derived from epidemiological and observational studies because it is difficult to address disease endpoints through clinical trials.

Owners can take a proactive approach regarding dental care — many of the more serious side effects of dental disease are avoidable through good maintenance care.

My veterinary practice strives to reduce my patients reliance on medications to manage diseases by promoting total body health through the use of whole food based diets, nutraceuticals (food derived substances having medicinal effects), acupuncture (needle, laser, etc.), and Chinese herbs.

We question the effect of injecting a disease into our dogs, thus putting a virus directly into the bloodstream that normally enters only through the mouth, respiratory system, etc., thus bypassing the entire primary immune response that occurs in the mucous membranes.

Requires the Secretary of HHS, acting through the Director of the Centers for Disease Control and Prevention (CDC) and other agencies, to: (1) assist health care professionals in preparing for and responding effectively and efficiently to the health effects of climate change; and (2) provide funding for research on such effects and preparedness planning to respond to or reduce the burden of such effects.

The most recent report from the Intergovernmental Panel on Climate Change states with «very high confidence» that «the health of human populations is sensitive to shifts in weather patterns and other aspects of climate change» due to direct effects — such as changes in temperature and precipitation or occurrence of heat waves, floods, droughts, and fires — as well as indirect effects — through crop failures, shifting patterns of disease vectors, or displacement of populations.

At field realistic doses, neonicotinoids cause a wide range of adverse sublethal effects in honeybee and bumblebee colonies, affecting colony performance through impairment of foraging success, brood and larval development, memory and learning, damage to the central nervous system, susceptibility to diseases, hive hygiene etc..

In the result, the judge declared the impugned provisions to be unconstitutional and of no force and effect to the extent they prohibited physician - assisted suicide in the case of a «fully - informed, non-ambivalent competent adult patient who: (a) is free from coercion and undue influence, is not clinically depressed, and who personally (not through a substitute decision - maker) requests physician - assisted death; and (b) is materially physically disabled or is soon to become so, has been diagnosed by a medical practitioner as having a serious illness, disease or disability... is in a state of advanced weakening capacities with no chance of improvement, has an illness as determined by reference treatment options acceptable to the person, and has an illness causing enduring physical or psychological suffering that is intolerable to that person and can not be alleviated by any medical treatment acceptable to that person».

This is true for the Torres Strait region, where the effect may be immediate; that is, as a result of a climate - change induced extreme weather, a threat that has already been felt when a young girl's life was at risk in the 2006 king tides; or it may occur gradually, through deterioration in health, diminished access to safe drinking water and increased susceptibility to disease.