A protein that acetylates core histones, resulting in important regulatory
effects on chromatin structure and assembly, and on gene transcription.
Not exact matches
Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater
effect on cellular division and regulation of
chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact
on DNA transcription and repair.
Steve's research focuses
on polyploid crops where he uses genomics and bioinformatics approaches to examine
chromatin structure and the
effect it has
on gene regulation.
We interfere with histone modification marks in vivo, both genome - wide (mutant analysis) and gene - specifically (local disruption of
chromatin structure), and analyze the
effect on transcription and pluripotency.
This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic
effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35
On the other hand, PU.1 is also shown to interact with
chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.
«In this study, researchers evaluated the
effect of dietary fats
on one particular
chromatin gene known to lengthen roundworm lifespan.