Sentences with phrase «effects on disease risk»

The associated alleles were common in the studied populations and all had only small effects on disease risk [123].

Identifying these, and quantifying their effects on disease risk, should lead to diagnostic and therapeutic approaches for improving human health.

It might be possible that nearby rare causal variants were in LD with the tag SNP, and these (not the tag SNP) exerted the causal effect on disease risk.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

And while there's some evidence that soy might slightly lower your risk of heart disease, the effects are minor — but more on that below.

While studies examining effects of chia on blood sugar control are ongoing, the protein, heart - healthy fats, fiber, and antioxidants found in chia seeds are beneficial for people with diabetes — especially those who want to keep heart - disease risks low and achieve or maintain a healthy weight.

Eating butter has no effect on raising cardiovascular disease (CVD) risk and may even have protective effects against diabetes, according to a review.

The effects of a whole grain - enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome.

This observation has precipitated numerous observational studies and randomized controlled trials of the effect of added sugars or SSB consumption on body weight and cardiovascular disease risk factors (6, 8, 9).

Introducing solid food Age of introduction and its effect on risk of food allergy and other atopic diseases.

For the individual, such small associations, even if real, will have only minor effects or no effect on overall health or risk of disease.

In multiple studies, lactation is associated with reduced maternal risk of type 2 diabetes mellitus.12, 22 Several studies have found differences in diabetes prevalence among postmenopausal women.22, 23 However, the only study to measure incident disease found that the association between breastfeeding and incident type 2 diabetes mellitus disappeared after 15 years after a woman's last birth.12 Thus, we limited the effect of lactation on type 2 diabetes mellitus accordingly.

Most studies have revealed protective effects of breastfeeding on common infections in the first 8 to12 months of life.8, 27,29,30 One study, which distinguished between infectious diseases until and from the age of 6 months, revealed results similar to those from our study.24 Although the authors used exclusive breastfeeding for 3 months as the reference group, exclusive breastfeeding for 6 months reduced the risk of gastrointestinal tract infections between the ages of 3 and 6 months but not between the ages of 6 and 12 months.24 We can not explain why breastfeeding duration was only associated with lower risks of lower respiratory tract infection from 7 to 12 months.

The Harvard School of Public Health says,» It's hard to argue with the health benefits of a diet rich in vegetables and fruits: Lower blood pressure; reduced risk of heart disease, stroke, and probably some cancers; lower risk of eye and digestive problems; and a mellowing effect on blood sugar that can help keep appetite in check.»

Although breastfeeding has modest effects on blood pressure (51) and adiposity (52, 53) in later life, it has numerous other health benefits, including protection against infectious disease morbidity (54) and mortality (55) in infancy and a lower risk of type 2 diabetes (56) and improved neural and psychosocial development in the longer term (57, 58).

And in several large - scale pharmaceutical trials, drugs specifically designed to elevate HDL had no effect on heart disease risk.

«Trans - fatty acids increase LDL cholesterol [our «bad» cholesterol], and they don't have much of an effect on HDL [our «good» cholesterol],» contributing to cardiovascular disease risk, says Alice Lichtenstein, a nutritional biochemist at Tufts University in Boston, who published a review on the topic in Current Atherosclerosis Reports in June 2014.

«Our findings highlight pregnancy as a sensitive period when positive lifestyle interventions could have significant and long - lasting beneficial effects on offspring metabolism and disease risk,» wrote the research team.

In the second study, a team of Danish researchers wanted to test the effect of a change in alcohol intake on the risk of breast cancer and heart disease.

The results for breast cancer are in line with previous research, but the true effect of alcohol on risk of ischaemic heart disease remains uncertain, say the editorial authors.

It's well known that dairy products contain calcium and minerals good for bones, but new research has shown that dairy consumption may also have beneficial effects on metabolic health and can reduce risk of metabolic diseases such as obesity and type 2 diabetes.

A version of the gene called APOE3 has no effect on Alzheimer's risk, whereas the APOE2 version protects against the disease.

Ju thinks it is unlikely that a single night or even a week of poor sleep, miserable though it may be, has much effect on overall risk of developing Alzheimer's disease.

«Both controlled - feeding studies that have examined the effects of trans fat on blood cholesterol and epidemiological studies of trans - fat intake in relation to the risk of heart disease and diabetes indicate they are considerably worse than saturated fats,» he says.

«Specifically, we are looking at the effects of these early factors on later levels of C - reactive protein (CRP), a biomarker associated with risk for cardiovascular and metabolic disease,» Metzger said.

Mary Elizabeth Hartnett, MD, and colleagues at the John A. Moran Center and Department of Pediatrics at the University of Utah and Children's Hospital of Wisconsin, were looking for a way to tease apart the effects of preeclampsia on the risk of developing retinopathy of prematurity (ROP), an eye disease found in premature infants.

The effects of sauna bathing on the risk of Alzheimer's disease and other forms of dementia were studied in the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD), involving more than 2,000 middle - aged men living in the eastern part of Finlrisk of Alzheimer's disease and other forms of dementia were studied in the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD), involving more than 2,000 middle - aged men living in the eastern part of Fdisease and other forms of dementia were studied in the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD), involving more than 2,000 middle - aged men living in the eastern part of FDisease Risk Factor Study (KIHD), involving more than 2,000 middle - aged men living in the eastern part of FinlRisk Factor Study (KIHD), involving more than 2,000 middle - aged men living in the eastern part of Finland.

Williams said, the long - term follow up allowed authors to examine dietary patterns and analyze the effect of gradual adherence to a plant - based diet through reduced animal food intake and increased plant food intake on heart disease risk.

Some genetic risk - factors for Alzheimer's disease can have effects on the inflammatory response, but infection may also play a role.

Dr. John Krystal, Editor of Biological Psychiatry, commented, «Alzheimer's disease presents such a terrible burden on individuals, families, and society that if BACE1 inhibitors produce beneficial effects on the course of this disorder, it is well worth the effort to try to understand and circumvent this new risk.»

We will also investigate whether the addition of probiotics (beneficial bacteria) to the diet has any effect on the risk of developing celiac disease,» explains Carin Andrén Aronsson, before adding:

However, the authors stress that «further clinical investigations will be essential to establish the optimal dose, duration and safety, and whether vitamin D2 or D3 have different effects on mortality risk, since the available trials are based on elderly populations in general (an age group with high competing risk of death often due to multiple co-existing disease conditions) and they do not typically include cause - specific deaths as the primary outcomes.»

We investigated the effects of coffee and tea on CV mortality and non-CV mortality in a large French population at low risk of cardiovascular diseases.»

Previous research has shown that being sedentary increases the risk of cardiovascular disease but until now its effect on patients with established heart disease was unknown.

«The favorable effect of coffee on liver cancer might be mediated by coffee's proven prevention of diabetes, a known risk factor for the disease, or for its beneficial effects on cirrhosis and liver enzymes.»

Dr Nelson added: «We also examined whether the association we found between shorter height and higher risk of coronary heart disease could be explained by an effect of height on known risk factors for coronary heart disease like cholesterol, high blood pressure, diabetes etc..

The evidence is clear from this study that a Minimum Unit Price would not have a significant effect on low risk drinkers but would target those for whom the impact of alcohol - related liver disease is most devastating.

Appel and Sacks led three earlier clinical trials that tested ways to reduce the risk of cardiovascular disease and diabetes, providing volunteers with carefully designed diets and measuring the effects on key health indicators.

For the health care system, the researchers estimated the change in risk of diabetes, colorectal cancer and coronary heart disease due to the healthier diets and the subsequent effect on both health care costs and greenhouse gas emissions.

The study shows that even low physical fitness, up to 20 % below the average for healthy people, is sufficient to produce a preventive effect on most of the risk factors that affect people with cardiovascular disease.

The results showed that normal physical fitness, even up to 20 % below the population average, is sufficient to have a preventive effect on five of the eight risk factors affecting people with cardiovascular disease — abdominal circumference, diabetes, hypertension, obesity, and excess weight.

· evidence supports a positive relationship between higher levels of sodium intake and risk of heart disease, which is consistent with previous research based on sodium's effects on blood pressure;

«Since we found previously that the gut microbiome — the communities of bacteria and other microbes living there — can influence liver disease risk, we wondered what effect gastric acid suppression might have on the progression of chronic liver disease.

An antioxidant that targets specific cell structures — mitochondria — may be able to reverse some of the negative effects of aging on arteries, reducing the risk of heart disease, according to a new study by the University of Colorado Boulder.

Globorisk measures cardiovascular risk in individuals aged 40 or older by factoring in the person's smoking status, blood pressure, diabetes status, and total cholesterol level, whilst adjusting for the effects of sex and age on cardiovascular disease between countries.

A new Concordia study goes further, however, focusing specifically on the effects of knowing a second language for patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI; a risk state for AD).

The risk of a febrile seizure following the MMR is approximately one case in 3,000 doses for children aged 12 to 15 months but one case in 1,500 doses for children aged 16 to 23 months «This study adds to the evidence that the best way to prevent disease and minimize side effects from vaccines is to vaccinate on the recommended schedule,» says Simon Hambidge, lead author of the study and the director of general pediatrics at Denver Health.

The panel concluded, among other things, that yoghurt and cheese have a different and more beneficial effect on bone health, body weight, the risk of developing cardiovascular diseases, than would be expected on the basis of their saturated fat and calcium content.

Although it is already known that being overweight or obese increases a person's risk of CVD, as well as other diseases such as cancer, there have also been studies that have suggested that, particularly in the elderly, being overweight or even obese might not have any effect on deaths from CVD or other causes, and may even be protective, especially if people maintain a reasonable level of fitness.

Walker said that the effect of one standard deviation increase in the overall inflammation score in mid-life on brain volume decades later was similar to the effect associated with having one copy of the apolipoprotein E (APOE) e4 gene that increases the risk of Alzheimer's disease.